Episode 331. Investigating myself. Topic: Is it me? For the first episode of this series, I compare my whole genome sequencing to the raw data from my health and ancestry test. How do these two methods differ in assessing genetic information.  Are both tests from the same individual? Do they always perfectly match?!

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Methodology notes: Paired-end fastq reads from whole genome sequencing (performed by Nebula genomics) were aligned to hg19 with bwa mem to match the genome version of the raw array calls from the health and ancestry test. The identity of the health and ancestry test will not be revealed. Genotypes at array loci were called with bcftools mpileup. Homozygous calls were interpreted as cases where one allele has an frequency of >0.9. Heterozygous calls were verified where two alleles each show an allele frequency of >= 0.1 and <= 0.9. 

Episode 330. Topic: How we differ. Theme: Genetics. How much DNA do humans have? How much does human DNA vary? Are humans a genetically diverse species ... or are we kind of inbred?

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 329. Topic: Sequencing DNA. Theme: Genetics. How does classic DNA sequencing work? How is it different today?

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 328. Topic: Chromosome counts. Theme: Genetics. What happens when humans have more or less than 46 chromosomes? Is it always fatal or even pathological? Why have some plants completely duplicated their genomes? Why do all great apes have one more chromosome than humans?

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 327. Topic: Who is the reference human genome? Theme: Genetics. We have a reference human genome, but whose DNA is it? Who is this reference human? Who decided what the reference human would be? How have geneticists been studying how human differ from this reference? 

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 326. Topic: The human genome project. Theme: Genetics. How old is DNA sequencing? Why was sequencing the whole human genome so difficult? How long did it take? How much did it cost? And what does human DNA sequencing look like today?

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Introducing a new series of bonus episodes for 3 minute lesson: Investigating myself. Each week I will look into my own genome and give a genetics lesson along the way. 

Do I carry any genetic diseases? Do my 23andMe results match my whole genome sequencing? Do I have the correct copy of all my chromosomes? I don't even know yet... so let's find out together! 

Show notes for Investigating myself episodes will contain a brief methodology. 

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 325. Topic: Human cloning. Theme: Cloning. Have humans ever been cloned? Is it legal? Is it always unethical? What would the future uses for human cloning be? 

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 324. Topic: Clone your dead pet. Theme: Cloning. Can a pet be commercially cloned? How much will it cost? Will the exact same animal be recreated? Are there health risks?

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!

Episode 323. Topic: Some frogs and Dolly. Theme: Cloning.  How does mammalian cloning work? How was Dolly the sheep cloned? Is cloning easier today? Does cloning happen without health ramifications? 

Twitter: @3minutelesson
Email: [email protected]
New episode every week day!