October 10, 2024

#368: First-Pass Metabolism Explained: Key Insights for Nurses

17 minutes

In this episode, I'm breaking down the concept of first-pass metabolism, also known as the first-pass effect, and why it’s important for nurses to understand. You’ll learn how medications are metabolized, why bioavailability matters, and how the first-pass effect impacts drug dosing and effectiveness. We also discuss common medications affected by this process and how it influences the choice of administration routes.

Listen to this episode and you’ll learn:

What first-pass metabolism is - Get a brief overview of how PO medications are metabolized in the liver before reaching systemic circulation

The basics of bioavailability - Learn how bioavailability measures how much of a drug reaches systemic circulation and why IV medications have higher bioavailability than oral medications.

Some common medications affected by first-pass metabolism - Bring this concept to life with medication examples including nitroglycerine and diazepam.

Nursing implications - Discover how understanding first-pass metabolism helps nurses administer medications effectively and why it impacts the timing of a drug's onset of action.

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Full Transcript - Read the article and view references

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By Maureen Osuna, MSN, RN - Nursing school educator, author, and nursing student enthusiast.

4.8

11971,197 ratings

October 10, 2024

#368: First-Pass Metabolism Explained: Key Insights for Nurses

17 minutes

Listen to this episode and you’ll learn:

What first-pass metabolism is - Get a brief overview of how PO medications are metabolized in the liver before reaching systemic circulation

The basics of bioavailability - Learn how bioavailability measures how much of a drug reaches systemic circulation and why IV medications have higher bioavailability than oral medications.

Some common medications affected by first-pass metabolism - Bring this concept to life with medication examples including nitroglycerine and diazepam.

Nursing implications - Discover how understanding first-pass metabolism helps nurses administer medications effectively and why it impacts the timing of a drug's onset of action.

___________________

Full Transcript - Read the article and view references

Pharmacology Success Pack - Want to get a head start on pharmacology? Download the FREE Pharmacology Success Pack.

Fast Pharmacology - Learn pharmacology concepts in 5 minutes or less in this audio based program. Perfect for on-the-go review!

💕Did you love this episode? Please take a moment to follow or subscribe to the show so you never miss an episode!

___________________

Straight a Nursing is a proud member of the Airwave Media Network.

Learn more about your ad choices. Visit megaphone.fm/adchoices

...more