A pulmonary embolism is a condition in which vessels in the lungs are blocked by a thrombus or other material that has traveled from somewhere else in the body. This is usually a result of a venous thromboembolism, but can also be due to amniotic fluid, air or fat embolus, or tumor material in patients with cancer.

A key thing to understand about pulmonary embolism is that the airway is not occluded. In pulmonary embolism, one or more blood vessels are occluded. What this means is that blood coming from the right side of the heart isn’t able to pass freely through the pulmonary vasculature to participate in gas exchange, which negatively affects perfusion.

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