From First Principles

3I/ATLAS Explained, Forensic Fingerprints & Alzheimer’s Breakthrough (EP. 18)


Listen Later

Hosted by Lester Nare and Krishna Choudhary, this episode spans astrophysics, forensic chemistry, and neuroimmunology. We begin with a deep dive into 3I/ATLAS, only the third confirmed interstellar object to ever pass through our solar system — larger and stranger than ‘Oumuamua and Borisov, with new imagery released as NASA reopened operations. Then we break down a true-crime forensic breakthrough from Maynooth University that reveals how to recover fingerprints from fired bullet casings — a technique that could radically accelerate criminal investigations. And we close with a Max Planck Institute discovery identifying a regulatory microglial state in the brain that may finally clarify why Alzheimer’s develops — and how immune dysfunction, not just plaques, drives the disease.


Summary

  • The third interstellar visitor — 3I/ATLAS joins ‘Oumuamua and Borisov as only the third object ever observed entering the solar system from interstellar space, with new NASA imagery revealing structure, trajectory, and compositional clues.


  • A forensic chemistry breakthrough — researchers at Maynooth University develop a technique to retrieve latent fingerprints from fired shell casings, combining heat-stable organic residues with spectroscopic imaging.


  • A new model of Alzheimer’s — Max Planck Institute scientists uncover a microglial “regulatory” state (a T-reg–like analogue) activated through CD28-dependent pathways, reshaping how the field thinks about plaques, neuroinflammation, and therapeutic targets.


Show Notes

  • 3I/ATLAS — Interstellar Object Updates (NASA / JPL)
  • Forensic Chemistry: Fingerprints on Fired Casings (Maynooth University)
  • Alzheimer’s Microglia Study — Max Planck Institute / Univ. of Cologne
...more
View all episodesView all episodes
Download on the App Store

From First PrinciplesBy Krishna Choudhary and Lester Nare

  • 4.9
  • 4.9
  • 4.9
  • 4.9
  • 4.9

4.9

74 ratings


More shows like From First Principles

View all
Freakonomics Radio by Freakonomics Radio + Stitcher

Freakonomics Radio

32,254 Listeners

Planet Money by NPR

Planet Money

30,732 Listeners

StarTalk Radio by Neil deGrasse Tyson

StarTalk Radio

14,349 Listeners

Planetary Radio: Space Exploration, Astronomy and Science by The Planetary Society

Planetary Radio: Space Exploration, Astronomy and Science

1,352 Listeners

The Quanta Podcast by Quanta Magazine

The Quanta Podcast

545 Listeners

Into the Impossible With Brian Keating by Big Bang Productions Inc.

Into the Impossible With Brian Keating

1,067 Listeners

The Michael Shermer Show by Michael Shermer

The Michael Shermer Show

952 Listeners

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas by Sean Carroll

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

4,184 Listeners

Within Reason by Alex J O'Connor

Within Reason

1,663 Listeners

The Prof G Pod with Scott Galloway by Vox Media Podcast Network

The Prof G Pod with Scott Galloway

5,674 Listeners

Doomscroll with Joshua Citarella by Joshua Citarella

Doomscroll with Joshua Citarella

283 Listeners

Hard Fork by The New York Times

Hard Fork

5,547 Listeners

The Ezra Klein Show by New York Times Opinion

The Ezra Klein Show

16,317 Listeners

The Weekly Show with Jon Stewart by Comedy Central

The Weekly Show with Jon Stewart

11,023 Listeners

Prof G Markets by Vox Media Podcast Network

Prof G Markets

1,472 Listeners