Although the majority of children who catch COVID recover without incident, some progress to multi-system inflammatory syndrome (MIS-C), thousands wind up in the ICU, and nearly 1,000 American children have died. Mark Kline, Physician-in-Chief, Senior Vice President and Chief Medical Officer of Children's Hospital New Orleans talks with Stephanie Desmon about why omicron is such “a different animal,” what’s next for vaccine trials for kids under five, and how Louisiana is taking big steps to protect children with vaccination mandates.