California has had a reputation as one of the more vigorous in terms of COVID-19 mitigation tactics and now, two years later, the state is changing tack. Dr. Mark Ghaly, California’s Secretary of Health and Human Services, talks with Dr. Josh Sharfstein about the state’s new and more nimble S.M.A.R.T.E.R. approach which focuses on key metrics and broad surveillance to know what responses are needed where. They also talk about what it’s been like to lead in this role during the pandemic.