The San Francisco 49ers are cutting down to their final 53-man roster for the 2025 NFL season, and big questions remain. Which wide receivers will step up with Brandon Aiyuk on PUP and DeMarcus Robinson suspended? Will rookie Sebastian Valdez or a surprise veteran sneak onto the defensive line? Can Nick Zakelj beat out Drew Moss for a crucial offensive line spot? And how many linebackers will the Niners keep between Curtis Robinson, Luke Gifford, and Chazz Surratt?We break down every position battle and make our full 49ers 53-man roster predictions, including practice squad candidates, surprise cuts, and depth chart sleepers. From Brock Purdy and Mac Jones at quarterback, Christian McCaffrey’s RB room with Brian Robinson, Isaac Guerendo, and Jordan James, to a new-look WR group led by Jauan Jennings, Ricky Pearsall, Jordan Watkins, Russell Gage, and Skyy Moore — we cover it all.On defense, Nick Bosa anchors a loaded D-line with Alfred Collins, Bryce Huff, Mykel Williams, and more, while Fred Warner leads the linebackers alongside Dee Winters and rising talent Tatum Bethune. In the secondary, battles heat up as Darrell Luter Jr. and Siran Neal fight for the last cornerback spot, with Ji’Ayir Brown, Jason Pinnock, and Richie Grant securing safety depth.This video reveals the 49ers’ potential 2025 depth chart, who’s headed to the practice squad, and the biggest surprises before Week 1 kickoff.
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