COVID-19 infections may look different in 2022 than they did in 2020, thanks to vaccines, infection-induced immunity, and new treatments—but that doesn’t mean we can rest easy. Dr. Paul Sax, clinical director of infectious diseases at the Brigham and Women’s Hospital and editor-in-chief of the Journal of Clinical Infectious Diseases talks with Dr. Josh Sharfstein about the overall state of COVID-19 treatments and vaccines, what we still don’t know about this virus, and why it’s important to stay vigilant.