On episode #90 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/12/25 – 9/24/25.

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• Viral
• Crushed Bictegravir/Emtricitabine/Tenofovir Alafenamide (OFID)
• Tracking County-Level Measles Cases in the US (JAMA Nework)
• Tracking measles in US (Hopkins)
•  Pediatric influenza-associated encephalopathy and acute necrotizing encephalopathy (MMWR)
• Clinical recommendations for Lenacapivir (MMWR) Bacterial
• Primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients (Antimicrob Steward Healthc Epidemiol)
• Clinical features and treatment strategies of Q fever spinal infection (OFID) Fungal
• Last of Us Season 2
• The Pain is in the Brain (J Inf Dis) Parasitic
• Chagas Disease, an Endemic Disease in the United States (MMWR)
• Fixed-dose ivermectin for Mass Drug Administration (PLoS NTD)
• Outbreak of eosinophilic meningitis caused by the rat lungworm (Angiostrongylus cantonensis) in South Brazil (Am J Trop Med Hyg)
• Human monoclonal antibody MAM01 for protection against malaria in adults in the USA (Lancet Inf Dis)
• Permethrin-Treated Baby Wraps for the Prevention of Malaria (NEJM) Miscellaneous
• Ambient Documentation Technology in Clinician Experience of Documentation Burden and Burnout (JAMA Network Open)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #89 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/18/25 – 9/11/25.

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• Viral
• Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination (OFID)
• Intestinal mucosal immune responses to novel oral poliovirus vaccine type 2 in healthy newborns (CID)
• Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza (NEJM)
• Fulminant Viral Myocarditis Associated with Thogotovirus (NEJM)
• Bacterial
• Risk factors for 30-Day mortality and the role of empirical therapy in Pseudomonas aeruginosa bloodstream infections(Infection)
• The Impact of a Nationwide Blood Culture Bottle Shortage in 2024 on Healthcare Facilities in the United States (CID)
• The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli(NPJ: antimicrobials and resistance)
• Preoperative Enterosignatures Predict Surgical Site Infections After Abdominal Surgery (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Association between Duration of Candidemia and Clinical and Healthcare Resource Utilization Outcomes among Hospitalized Adult Patients with Candidemia Who Received Empiric Treatment with an Echinocandin Across United States Hospitals (CID)
• Updating the epidemiology of blastomycosis and histoplasmosis in the United States, using national electronic health record data, 2013–2023 (JID)
• Parasitic
• Stocking African catfish in Lake Victoria provides effective biocontrol of snail vectors of Schistosoma mansoni (PLoS Neglected Tropical Disease)
• Miscellaneous

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #88 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/19/25 – 8/27/25.

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• Viral
• Respiratory Syncytial Virus Immunization Coverage Among Infants Through Receipt of Nirsevimab Monoclonal Antibody or Maternal Vaccination (CDC: MMWR)
• Bictegravir, emtricitabine, and tenofovir alafenamide versus ritonavir-boosted protease inhibitor-based antiretroviral therapy in people with HIV and viral suppression on second-line therapy in Haiti: an open-label, randomised, non-inferiority trial (LANCET: HIV)
• Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial (CID)
• Bacterial
• Exposure to suppressive antibiotic therapy in women with recurrent urinary tract infections and severity of infections: a retrospective population-based cohort study (BMJ Open)
• Effectiveness and safety of antibiotics in kidney transplant recipients with asymptomatic bacteriuria: a systematic review and meta-analysis of randomized controlled trials (OFID)
• Epidemiological, temporal, and geographic trends of leptospirosis in the United States, 2014–2020 (PLoS Neglected Tropical Diseases)
• Performance of Tongue Swabs for Tuberculosis Diagnosis in Hospitalized Children Under 5 Years of Age (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Towards shorter therapy for candidaemia: defining uncomplicated candidaemia in adults (LANCET: Infectious Diseases)
• Parasitic
• Outcomes of Military Blood Donors at Joint Base San Antonio with Reactive Trypanosoma cruzi Antibody Screening (OFID)
• Cutaneous acanthamoebiasis: Two Cases Highlighting Diverse Histopathologic Findings (Journal of Cutaneous Pathology)
• Miscellaneous
• Linezolid-related Optic Nerve Disorders: Insight from a Pharmacovigilance Analysis of the U.S. FDA Adverse Event Reporting System (OFID)
• Extreme variability in linezolid concentrations in the ICU: A case for routine therapeutic drug monitoring (American Journal of Health-System Pharmacy)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #87 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/31/25 – 8/18/25.

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• Viral
• Adjuvanted recombinant zoster vaccine is effective against herpes zoster ophthalmicus, and is associated with lower risk of acute myocardial infarction and stroke in adults aged ≥50 years (CID)
• Bacterial
• Dalbavancin for Treatment of Staphylococcus aureus Bacteremia (JAMA)
• Propensity-Matched Comparison of Timely vs. Delayed Antibiotic Therapy in Stenotrophomonas maltophilia Pneumoni (OFID)
• The proportion of Treponema pallidum PCR-positive primary syphilis infections which are seronegative for syphilis (OFID)
• Cefixime versus benzathine penicillin G for the treatment of early syphilis (Journal of Antimicrobial Chemotherapy)
• Dalbavancin for Treatment of Staphylococcus aureus Bacteremia (JAMA)
• Fungal
• The Last of US Season 2 (YouTube)
• Parasitic
• Increasing Length of the Babesia Season in New England in the Climate Change Era (OFID)
• Ivermectin to Control Malaria (NEJM)
• Miscellaneous
• ACIP Recommendations Summary (CDC: Influenza)
• Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to frailty score (JID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #86 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/22 – 8/1/25.

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• Viral
• Long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection (BMC Medicine)
• Bacterial
• War on AMR: High MDR carriage rates among war-injured Ukrainian refugees (CMI: Clinical Microbiology and Infection)
• Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Progression from Candida auris Colonization Screening to Clinical Case Status, United States, 2016–2023 (CDC: Emerging Infectious Diseases)
• Regional Emergence of Candida auris in Chicago and Lessons Learned From Intensive Follow-up at 1 Ventilator-Capable Skilled Nursing Facility (CID)
• Infection Control Guidance: Candida auris (CDC: Candida auris)
• Twice Weekly Sulfamethoxazole/Trimethoprim for Pneumocystis jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients(Transplant Infectious Disease)
• Parasitic
• Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain (PLoS Pathogens)
• Baylisascariasis (Raccoon Roundworm Infection) in Two Unrelated Children  (CDC: MMWR)
• Miscellaneous
• A Review of Alpha Gal Syndrome for the Infectious Diseases Practitioner (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #85 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/3 – 7/21/25.

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• Viral
• Elimination of HIV Reservoirs Harboring Intact Proviruses (JID) Bacterial
• Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018–2024 (NEJM)
• Study hints doxyPEP use coincides with rise in tetracycline-resistant gonorrhea in US (CIDRAP)
• Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in Neisseria gonorrhoeae and Colonization With Tetracycline-Resistant Staphylococcus aureus and Group A Streptococcus (CID)
• Methenamine hippurate asprophylaxis for recurrent urinary tract infections in older women – a triple-blind, randomised, placebo-controlled, phase IV trial (ImpresU). (CMI: Clinical Microbiology and Infection)
• Diagnosis and Management ofCommunity-acquired Pneumonia(American Journal of Respiratory and Critical Care Medicine)
• Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management (IDSA)
• The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria (Antimicrobial Stewardship & Healthcare Epidemiology) Fungal
• The Last of US Season 2 (YouTube)
• Candida auris Containment Responses in Health Care Facilities that Provide Hemodialysis Services (CDC: MMWR)
• Candidozyma auris: an emerging threat (Reflections on Infectious Prevention and Control)
• Effects of postoperative antifungal therapy on the recurrence of Aspergillus infection after pulmonary aspergilloma resection (BMC Infectious Diseases)
• Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study (LANCET: Microbe)
• Large language models and their performance for the diagnosis of histoplasmosis (PLoS Neglected Tropical Diseases) Parasitic
• Field evidence of Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the Chagas disease vector in Florida, USA (PLoS Neglected Tropical Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #84 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/17 – 7/2/25.

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• Viral
• Clinical Outcomes and Perspectives of People With Human Immunodeficiency Virus Type 1 Twelve Months After Initiation of Long-acting Cabotegravir and Rilpivirine in an Observational Real-world US Study (BEYOND)(CID)
• Healthcare Provider Knowledge of West Nile Virus Diagnostic Testing—United States, 2022 (OFID)
• Bacterial
• Risk and Distribution of Metastatic Infections by Primary Infection Focus in Staphylococcus aureus Bacteremia (OFID)
• Clinical management of Clostridioides difficile infection with faecal microbiota transplantation (eClinicalMedicine)
• Clinical Practice Guidelines for the Management of Clostridioides difficile Infection in Adults (IDSA)
• Clinician Management Preferences for Clostridioides difficile Infection in Adults (OFID)
• Donor-Derived Tuberculosis In Three Solid Organ Transplant Recipients From The Same Donor (OFID)
• Septic Arthritis and Osteomyelitis in Finger Caused by Mycoplasma phocimorsus from Brown Bear, Alaska, USA (CDC: Emerging Infectious Diseases)
• Foodborne Botulism Outbreak After Consumption of Home-Canned Cactus (Nopales) (CDC: MMWR)
• One-Stage Revision Total Hip Arthroplasty for Polymicrobial Periprosthetic Joint Infection Leads to High Reinfection Rates (Journal of Arthroplasty)
• 4,000-year-old Mycobacterium lepromatosis genomes from Chile reveal long establishment of Hansen’s disease in the Americas (Nature Ecology & Evolution)
• Fungal
• The Last of US Season 2 (YouTube)
• Outcome Predictors of Candida Prosthetic Joint Infection (OFID)
• Parasitic
• Miscellaneous
• Ten Practical Tips for a Successful Presentation at ID clinical case conference (OFID)
• Evaluating the impact of two decades of USAID interventions and projecting the effects of defunding on mortality up to 2030 (LANCET)
• Comparison of Periodic In-Person ID Care to Daily Tele-ID Care at a Community Hospital (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #83 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/5 – 6/18/25.

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• Viral
• Premature Demise of the Milwaukee Protocol (CID)
• West Nile Virus and Other Nationally Notifiable Arboviral Diseases — United States, 2023 (CDC: MMWR)
• Investigation of associations between the neonatal gut microbiota and severe viral lower respiratory tract infections in the first 2 years of life (LANCET: Microbe)
• Right blend of gut microbiota could avert hospitalization forviral respiratory infection in babies (CIDRAP)
• Clinical management and infection prevention and control for mpox: living guideline, May 2025 (World Health Organization)
• Bacterial
• Corynebacterium diphtheriaeOutbreak in Migrant Populations in Europe (NEJM)
• Weekly Oral Cycling Antibiotic Treatment: A New Antibioprophylaxis Regimen for Recurrent UTIs (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Estimated Burden of Coccidioidomycosis (JAMA)
• Antifungal therapy in Candida infective endocarditis: a comparison of echinocandins and other treatment regimens in a nation-wide cohort study (CID)
• Parasitic Does schistosome infection affect behavior through the gut-brain axis? (PLoS Neglected Tropical Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #82 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/22 – 6/4/25.

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• Viral
• Estimated Current and Future Congenital Rubella Syndrome Incidence with and Without Rubella Vaccine Introduction — 19 Countries, 2019–2055 (CDC: MMWR)
• HIV-Superinfection in Kidney Transplant Recipients with HIV who Received Organs from Donors with HIV (JID)
• Respiratory syncytial virus: an under-recognized healthcare-associated infection (Infection Control and Hospital Epidemiology)
• Bacterial
• Francisella tularensis Subspecies holarctica in Stranded Beluga Whales, Cook Inlet, Alaska, USA (CDC: Emerging Infectious Diseases)
• Long-term effects of azithromycin mass administration to reduce childhood mortality on Streptococcus pneumoniae antimicrobial resistance (LANCET: Infectious Diseases)
• Reducing inappropriate antibiotic use in febrile neutropenia in hematology patients through the implementation of an antibiotic de-escalation protocol (Infection Control and Hospital Epidemiology)
• Optimizing cefazolin dosing for central nervous system infections: insights from population pharmacokinetics and Monte Carlo simulations (Antimicrobial Agents and Chemotherapy)
• Fungal
• The Last of US Season 2 (YouTube)
• Histoplasma antigenuria prevalence in patients with advanced HIV disease in Côted’Ivoire (CID)
• Interferon-γ therapy in patients with refractory disseminated coccidioidomycosis(CID)
• Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections (Clinical Microbiology Reviews)
• Parasitic
• Notes from the Field: Primary Amebic Meningoencephalitis Associated with Nasal Irrigation Using Water from a Recreational Vehicle — Texas, 2024 (CDC: MMWR)
• Further Evidence for Plausible Transmission of Fishborne Trematodiases in the United States: Game Fish Carry Human-Infectious Trematodes and Are Eaten Raw (JID)
• Miscellaneous
• A pilot study of coughing into the shirt to disrupt respiratory pathogen transmission (International Journal Of Emergency Medicine)
• Applying new compound to bed nets targets malaria parasites, not mosquitoes (CIDRAP)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #81 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 5/8/25 – 5/21/25.

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• Viral
• Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo (NEJM)
• Remdesivir associated with reduced mortality in hospitalized COVID-19 patients (BMC Infectious Diseases)
• Real-world evidence shows remdesivir tied to less death in hospitalized COVID patients (CIDRAP)
• Impact of most promising Ebola therapies on survival (Virology Journal)
• Bacterial
• Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams (CID)
• Diet and Risk for Incident Diverticulitis in Women (Annals of Internal Medicine)
• The Dynamics of QuantiFERON-TB Gold In-Tube Conversion and Reversion in a Cohort of South African Adolescents(American Journal of Respiratory and Critical Care Medicine)
• BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection(NEJM)
• The Impact of Diet on Clostridioides difficile Infection (JID)
• Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcusaureus Bacteremia (CMI: Clinical Microbiology and Infection)
• Fungal
• The Last of US Season 2 (YouTube)
• Candida auris is emerging as a prevalent urinary pathogen (PLoS Pathgoens
• A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis (Science)
• Outcome predictors of Candida prosthetic joint infections (OFID)
• Cave-Associated Histoplasmosis Outbreak Among Travelers Returning from Costa Rica — Georgia, Texas, and Washington, December 2024–January 2025 (CDC: MMWR)
• Parasitic
• COPEG 25th Anniversary (US Embassy in Panama)
• USDA suspends southern border livestock imports over New World screwworm threat(CIDRAP)
• Moxidectin combination therapies for lymphatic filariasis (LANCET: Infectious Diseases

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.