On episode #86 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/22 – 8/1/25.

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• Viral
• Long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection (BMC Medicine)
• Bacterial
• War on AMR: High MDR carriage rates among war-injured Ukrainian refugees (CMI: Clinical Microbiology and Infection)
• Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Progression from Candida auris Colonization Screening to Clinical Case Status, United States, 2016–2023 (CDC: Emerging Infectious Diseases)
• Regional Emergence of Candida auris in Chicago and Lessons Learned From Intensive Follow-up at 1 Ventilator-Capable Skilled Nursing Facility (CID)
• Infection Control Guidance: Candida auris (CDC: Candida auris)
• Twice Weekly Sulfamethoxazole/Trimethoprim for Pneumocystis jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients(Transplant Infectious Disease)
• Parasitic
• Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain (PLoS Pathogens)
• Baylisascariasis (Raccoon Roundworm Infection) in Two Unrelated Children  (CDC: MMWR)
• Miscellaneous
• A Review of Alpha Gal Syndrome for the Infectious Diseases Practitioner (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #85 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/3 – 7/21/25.

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• Viral
• Elimination of HIV Reservoirs Harboring Intact Proviruses (JID) Bacterial
• Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018–2024 (NEJM)
• Study hints doxyPEP use coincides with rise in tetracycline-resistant gonorrhea in US (CIDRAP)
• Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in Neisseria gonorrhoeae and Colonization With Tetracycline-Resistant Staphylococcus aureus and Group A Streptococcus (CID)
• Methenamine hippurate asprophylaxis for recurrent urinary tract infections in older women – a triple-blind, randomised, placebo-controlled, phase IV trial (ImpresU). (CMI: Clinical Microbiology and Infection)
• Diagnosis and Management ofCommunity-acquired Pneumonia(American Journal of Respiratory and Critical Care Medicine)
• Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management (IDSA)
• The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria (Antimicrobial Stewardship & Healthcare Epidemiology) Fungal
• The Last of US Season 2 (YouTube)
• Candida auris Containment Responses in Health Care Facilities that Provide Hemodialysis Services (CDC: MMWR)
• Candidozyma auris: an emerging threat (Reflections on Infectious Prevention and Control)
• Effects of postoperative antifungal therapy on the recurrence of Aspergillus infection after pulmonary aspergilloma resection (BMC Infectious Diseases)
• Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study (LANCET: Microbe)
• Large language models and their performance for the diagnosis of histoplasmosis (PLoS Neglected Tropical Diseases) Parasitic
• Field evidence of Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the Chagas disease vector in Florida, USA (PLoS Neglected Tropical Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #84 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/17 – 7/2/25.

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• Viral
• Clinical Outcomes and Perspectives of People With Human Immunodeficiency Virus Type 1 Twelve Months After Initiation of Long-acting Cabotegravir and Rilpivirine in an Observational Real-world US Study (BEYOND)(CID)
• Healthcare Provider Knowledge of West Nile Virus Diagnostic Testing—United States, 2022 (OFID)
• Bacterial
• Risk and Distribution of Metastatic Infections by Primary Infection Focus in Staphylococcus aureus Bacteremia (OFID)
• Clinical management of Clostridioides difficile infection with faecal microbiota transplantation (eClinicalMedicine)
• Clinical Practice Guidelines for the Management of Clostridioides difficile Infection in Adults (IDSA)
• Clinician Management Preferences for Clostridioides difficile Infection in Adults (OFID)
• Donor-Derived Tuberculosis In Three Solid Organ Transplant Recipients From The Same Donor (OFID)
• Septic Arthritis and Osteomyelitis in Finger Caused by Mycoplasma phocimorsus from Brown Bear, Alaska, USA (CDC: Emerging Infectious Diseases)
• Foodborne Botulism Outbreak After Consumption of Home-Canned Cactus (Nopales) (CDC: MMWR)
• One-Stage Revision Total Hip Arthroplasty for Polymicrobial Periprosthetic Joint Infection Leads to High Reinfection Rates (Journal of Arthroplasty)
• 4,000-year-old Mycobacterium lepromatosis genomes from Chile reveal long establishment of Hansen’s disease in the Americas (Nature Ecology & Evolution)
• Fungal
• The Last of US Season 2 (YouTube)
• Outcome Predictors of Candida Prosthetic Joint Infection (OFID)
• Parasitic
• Miscellaneous
• Ten Practical Tips for a Successful Presentation at ID clinical case conference (OFID)
• Evaluating the impact of two decades of USAID interventions and projecting the effects of defunding on mortality up to 2030 (LANCET)
• Comparison of Periodic In-Person ID Care to Daily Tele-ID Care at a Community Hospital (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #83 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/5 – 6/18/25.

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• Viral
• Premature Demise of the Milwaukee Protocol (CID)
• West Nile Virus and Other Nationally Notifiable Arboviral Diseases — United States, 2023 (CDC: MMWR)
• Investigation of associations between the neonatal gut microbiota and severe viral lower respiratory tract infections in the first 2 years of life (LANCET: Microbe)
• Right blend of gut microbiota could avert hospitalization forviral respiratory infection in babies (CIDRAP)
• Clinical management and infection prevention and control for mpox: living guideline, May 2025 (World Health Organization)
• Bacterial
• Corynebacterium diphtheriaeOutbreak in Migrant Populations in Europe (NEJM)
• Weekly Oral Cycling Antibiotic Treatment: A New Antibioprophylaxis Regimen for Recurrent UTIs (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Estimated Burden of Coccidioidomycosis (JAMA)
• Antifungal therapy in Candida infective endocarditis: a comparison of echinocandins and other treatment regimens in a nation-wide cohort study (CID)
• Parasitic Does schistosome infection affect behavior through the gut-brain axis? (PLoS Neglected Tropical Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #82 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/22 – 6/4/25.

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• Viral
• Estimated Current and Future Congenital Rubella Syndrome Incidence with and Without Rubella Vaccine Introduction — 19 Countries, 2019–2055 (CDC: MMWR)
• HIV-Superinfection in Kidney Transplant Recipients with HIV who Received Organs from Donors with HIV (JID)
• Respiratory syncytial virus: an under-recognized healthcare-associated infection (Infection Control and Hospital Epidemiology)
• Bacterial
• Francisella tularensis Subspecies holarctica in Stranded Beluga Whales, Cook Inlet, Alaska, USA (CDC: Emerging Infectious Diseases)
• Long-term effects of azithromycin mass administration to reduce childhood mortality on Streptococcus pneumoniae antimicrobial resistance (LANCET: Infectious Diseases)
• Reducing inappropriate antibiotic use in febrile neutropenia in hematology patients through the implementation of an antibiotic de-escalation protocol (Infection Control and Hospital Epidemiology)
• Optimizing cefazolin dosing for central nervous system infections: insights from population pharmacokinetics and Monte Carlo simulations (Antimicrobial Agents and Chemotherapy)
• Fungal
• The Last of US Season 2 (YouTube)
• Histoplasma antigenuria prevalence in patients with advanced HIV disease in Côted’Ivoire (CID)
• Interferon-γ therapy in patients with refractory disseminated coccidioidomycosis(CID)
• Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections (Clinical Microbiology Reviews)
• Parasitic
• Notes from the Field: Primary Amebic Meningoencephalitis Associated with Nasal Irrigation Using Water from a Recreational Vehicle — Texas, 2024 (CDC: MMWR)
• Further Evidence for Plausible Transmission of Fishborne Trematodiases in the United States: Game Fish Carry Human-Infectious Trematodes and Are Eaten Raw (JID)
• Miscellaneous
• A pilot study of coughing into the shirt to disrupt respiratory pathogen transmission (International Journal Of Emergency Medicine)
• Applying new compound to bed nets targets malaria parasites, not mosquitoes (CIDRAP)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #81 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 5/8/25 – 5/21/25.

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• Viral
• Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo (NEJM)
• Remdesivir associated with reduced mortality in hospitalized COVID-19 patients (BMC Infectious Diseases)
• Real-world evidence shows remdesivir tied to less death in hospitalized COVID patients (CIDRAP)
• Impact of most promising Ebola therapies on survival (Virology Journal)
• Bacterial
• Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams (CID)
• Diet and Risk for Incident Diverticulitis in Women (Annals of Internal Medicine)
• The Dynamics of QuantiFERON-TB Gold In-Tube Conversion and Reversion in a Cohort of South African Adolescents(American Journal of Respiratory and Critical Care Medicine)
• BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection(NEJM)
• The Impact of Diet on Clostridioides difficile Infection (JID)
• Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcusaureus Bacteremia (CMI: Clinical Microbiology and Infection)
• Fungal
• The Last of US Season 2 (YouTube)
• Candida auris is emerging as a prevalent urinary pathogen (PLoS Pathgoens
• A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis (Science)
• Outcome predictors of Candida prosthetic joint infections (OFID)
• Cave-Associated Histoplasmosis Outbreak Among Travelers Returning from Costa Rica — Georgia, Texas, and Washington, December 2024–January 2025 (CDC: MMWR)
• Parasitic
• COPEG 25th Anniversary (US Embassy in Panama)
• USDA suspends southern border livestock imports over New World screwworm threat(CIDRAP)
• Moxidectin combination therapies for lymphatic filariasis (LANCET: Infectious Diseases

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #80 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/24/25 – 5/7/25.

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• Viral
• Incidence and Timing of Epstein–Barr Virus Whole Blood DNAemia in Epstein–Barr Virus-Mismatched Adult and Pediatric Solid Organ Transplant Recipients (Transplant Infectious Disease)
• Infant Respiratory Syncytial Virus Immunization Coverage in the Vaccine Safety Datalink: 2023–2024 (American Academy of Pediatrics)
• Impact of Nirsevimab on RSV and Non-RSV Severe Respiratory Infections in Hospitalized Infants (Influenza and other respiratory viruses)
• Hospital admissions of respiratory infections in infants plungewith nirsevimab RSV antibody (CIDRAP)
• Time to antiviral treatment in mild–moderate COVID-19 in the emergency department (Internal and Emergency Medicine)
• Delays in COVID antiviral receipt raised risk of poor outcomes after ED visits by 18%, data suggest (CIDRAP)
• Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV (MMWR)
• Bacterial
• Validation and clinical implementation of cerebrospinal fluid C-reactive protein for the diagnosis of bacterial meningitis (LANCET: Regional Health)
• Bridging to transplant: TDM-Guided Outpatient Dalbavancin Therapy in Chronic Granulomatous Disease with deep-seeded Inoperable Abscesses over 11 Months (OFID)
• Nitrites for Urinary Tract Infection—Time to Say Goodbye? (JAMA: Internal Medicine)
• Fungal
• The Last of US Season 2 (YouTube)
• High Mortality and Associated Risk Factors in Kidney Transplant Recipients with Cryptococcosis – A Nationwide Cohort Study Over a Decade Using USRDS Data (OFID)
• Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis (JID)
• Parasitic
• Performance of a novel P. falciparum rapid diagnostic test in areas of widespread hrp2/3 gene deletion (CID)
• Prevalence of Anopheles stephensi in the Horn of Africa: a systematic review and meta-analysis (BMC Infectious Diseases)
• Raising awareness of Demodex mites: a neglected cause of skin disease (Infection)
• Miscellaneous
• Scientific Integrity Under Threat: The Role of the IDSA, PIDS, and SHEA Journals in an Evolving Political Landscape (CID)
• Reasoning on Rounds Volume 2: a Framework for Teaching Management Reasoning in the Inpatient Setting (Journal of General Internal Medicine)
• Billing for and documentation of provider-to-provider interprofessional consults in infectious diseases (Journal of the Pediatric Infectious Diseases Society)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #79 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/10/25 – 4/23/25.

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• Viral
• An ancient Epstein-Barr virus genome recovered from a museum penis gourd from Papua (JID)
• Patterns of Decline in Measles, Mumps, and Rubella Neutralizing Antibodies and Protection Levels Through 10 Years After a Second and Third Dose of MMR Vaccine (OFID)
• Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo(NEJM)
• Bacterial
• Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay(Science Translational Medicine)
• New handheld device can diagnose TB without a lab in under an hour, its developers say(CIDRAP)
• Maternal mastitis and streptococcal toxic shock syndrome risk from breastfeeding children with scarlet fever (LANCET: Infectious Diseases)
• Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit(Infectious Diseases and Therapy)
• Bacteremia in Pediatric Solid Organ Transplant Recipients within 1 Year of Transplant(Transplant Infectious Disease)
• Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1) (LANCET)
• Consequences of Climate Change on the Emergence of Pathogenic, Environmentally Acquired Nontuberculous Mycobacteria (OFID)
• Addition of Macrolide Antibiotics for Hospital Treatment of Community-Acquired Pneumonia (JID)
• Point-of-Care Testingby Multiplex-PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation(Transplant Infectious Disease)
• Fungal
• The Last of US Season 2 (YouTube)
• Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome (Science Advances)
• Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis (JID)
• Parasitic
• Uganda launches largest malaria vaccine introduction to date(WHO: Uganda)
• Long-term follow-up of individuals with Chagas disease treated with posaconazole and benznidazole in a non-endemic region(CMI: Clinical Microbiology and Infection)
• Miscellaneous
• Monoclonal Antibodies From Children With Acute Kawasaki Disease Identify a Common Antigenic Target in Fatal Cases Over 5 Decades (Laboratory Investigation)
• Screwworm Cochliomyia hominivorax (Facebook)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #78 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/27/25 – 4/9/25.

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• Viral
• Demise of the Milwaukee protocol for rabies (CID)
• A natural experiment on the effect of herpes zoster vaccination on dementia (Nature)
• Taking a shot at dementia(microbeTV: TWiV)
• Recommendations from the 10th European Conference on Infections in Leukaemia for the management of cytomegalovirusin patients after allogeneic haematopoietic cell transplantation and other T-cell-engaging therapies (LANCET: Infectious Diseases)
• Epstein-Barr virus exposure precedes Crohn`s disease development (Gastroenterology aga)
• Bacterial
• Blujepa (gepotidacin) approved by US FDA for treatment of uncomplicated urinary tract infections (uUTIs) in female adults and paediatric patients 12 years of age and older (GSK)
• GSK wins FDA nod for first oral UTI antibiotic in almost 30 years(BioSpace)
• Efficacy and safety of individualised versus standard 10-day antibiotic treatment in children with febrile urinary tract infection (INDI-UTI): a pragmatic, open-label, multicentre, randomised, controlled, non-inferiority trial in Denmark (LANCET: Infectious Diseases)
• Frequency and severity of Myasthenia Gravis exacerbations associated with the use of ciprofloxacin, levofloxacin, and azithromycin (Muscle & Nerve)
• The cost of blood cultures: a barrier to diagnosis in low-income and middle-income countries
• (LANCET: Microbe)
• Rethinking blood culture (LANCET: Microbe)
• Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data and Outcomes(CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Cracks in the curriculum: the hidden deficiencies in fungal disease coverage in medical books (OFID)
• Kazachstania slooffiae fungemia: a case report and literature review on an emerging opportunistic pathogen in humans (OFID)
• Plasma microbial cell-free DNS metagenomic sequencing for diagnosis of invasive fungal diseases among high risk outpatient and inpatient immunocompromised hosts (CID)
• Parasitic
• Fatal Case of Splash Pad–Associated Naegleria fowleri Meningoencephalitis — Pulaski County, Arkansas, September 2023 (CDC: MMWR)
• Notes from the Field: Fatal Acanthamoeba Encephalitis in a patient who regularly used tap water in an electronic nasal irrigation device and a continuous positive airway pressure machine at home — new Mexico, 2023 (CDC: MMWR)
• Malaria (NEJM)
• Miscellaneous
• FDA grants marketing authorization of first home test for chlamydia, gonorrhea and trichomoniasis (FDA)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #77 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/13/25 – 3/26/25.

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• Viral
• Food is medicine for human immunodeficiency virus: improved health and hospitalizations in the changing health through food support (chefs-hiv) pragmatic randomized trial (JID)
• The epidemiology and burden of human parainfluenza virus hospitalizations in u.s. children (Journal of the Pediatric Infectious Diseases Society)
• Bacterial
• Epidemiology and outcomes of bloodstream infections in patients in a burns intensive care unit: an eight-year retrospective study(OFID)
• Prophylactic vancomycin in the primary prevention of clostridium difficile in allogeneic stem cell transplant(Transplant Infectious Disease)
• Incidence of scrub typhus in rural south India (NEJM)
• Antibiotic treatment for 7 versus 14 days in patients with bloodstream infections(NEJM)
• Blood Culture–Negative Endocarditis(Journal of the American Heart Association)
• Brucella suis Infection in Cardiac Implantable Device of Man Exposed to Feral Swine Meat, Florida, USA (CDC Emerging Infectious Diseases)
• Hyperbilirubinemia at hospitalization predicts nosocomial infection in decompensated cirrhosis (Hepatology Communicatons)
• Fungal
• The Last of US Season 2 (YouTube)
• Fungal Infections in People Who Use Drugs (OFID)
• IDSA 2025 guideline update on the treatment of asymptomatic histoplasma pulmonary nodules (histoplasmomas) and mild or moderate acute pulmonary histoplasmosis in adults, children, and pregnant people(IDSA: Infectisous Disease Society of America)
• Changing trends in the sources and volumes of clinical cultures with Candida auris at a large health system, 2019-2023 (American Journal of Infection Control)
• Diagnostic test accuracy of the Fungitell serum (1→3)-β-D-glucan assay for the diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis (CMI: Clinical Microbiology and Infection)
• Parasitic
• Impact of Strongyloides stercoralis Coinfection on Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis (OFID)
• Hematology thin smears perform equally to parasitology thick and thin blood smears for the diagnosis of Plasmodium and Babesia infections in a low prevalence setting (Journal of Clinical Microbiology)
• Notes from the Field: Rhodesiense Human African Trypanosomiasis (Sleeping Sickness) in a Traveler Returning from Zimbabwe — United States, August 2024 (CDC: MMWR)
• Miscellaneous
• The history of phage therapy LANCET: Infectious Diseases)
• Silence=death redux: infectious diseases, public health, and the imperative to resist (CID)
• Silence = Death, 1990(David Wojnarowicz Foundation)
• SILENCE=DEATH (B200KLYN Museaum)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.