Infectious Disease Puscast

On episode #116 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/16 – 9/21/26.

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• Viral
• Oya Virus in a Patient with Severe Hepatitis, Enteritis, and Coagulopathy (NEJM)
• Two Versus One COVID-19 Vaccine Dose After Prior SARS-CoV-2 Infection: A Nationwide Retrospective Cohort Study (OFID)
• Comparison of Silevimig, a Novel Bispecific Anti-Rabies Monoclonal Antibody, with Human Rabies Immunoglobulin for Post-Exposure Prophylaxis: A Phase III, Randomized, Double-Blind, Non-Inferiority Trial (CID)
• Bacterial
• R.E.M. – It's The End Of The World (YouTube)
• Companion Animals Harbour Globally Circulating Human-Associated Klebsiella pneumoniae Lineages and High-Risk Antimicrobial Resistance Clones (Transboundary and Emerging Diseases)
• Air contamination and cross-room transmission of carbapenem resistant Acinetobacter baumannii in ICU (American Journal of Infection Control)
• Economic Outcomes of Dalbavancin versus Standard Therapy in Staphylococcus aureus Bacteremia in the DOTS Randomized Clinical Trial (CID)
• Cephalexin Model-Informed Dosing Recommendations for Severe Infections: A Pooled Pharmacokinetic Analysis From Infancy to Adulthood (OFID)
• Initial Carbapenem Choice Versus Sustained Single-Group Therapy in the Albumin-Carbapenem Interaction (CID)
• Identification and Quantification of Pathogens in Pleural Fluid from Children with Complicated Pneumonia using the BioFire® FilmArray® Pneumonia Panel (Journal of Pediatric Infectious Diseases Society)
• Effectiveness of oral care for the prevention of non-ventilator hospital-acquired pneumonia (HAPPEN): a multicentre, stepped-wedge, cluster-randomised trial in Australia (LANCET: Infectious Diseases)
• Fungal
• The Last of US Season 2 (YouTube)
• Health Economic Analysis of the AMBITION Protocol for Human Immunodeficiency Virus–Associated Cryptococcal Meningitis in the United States (CID)
• Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (NEJM)
• Parasitic
• Vampire bats in Belize harbor multiple Trypanosoma cruzi genotypes: Implications for parasite transmission at the wildlife–domestic–human interface (PLoS Neglected Tropical Diseases)
• Community-acquired coinfections in adults with severe imported malaria: a systematic review and meta-analysis (CMI: Clincial Microbiology and Infection)
• Treatment for Leishmaniasis using liposomal amphotericin for immune compromised patients (in Portguese(Brazil.gov))
• Reactivation of Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Undergoing Tocilizumab Treatment (AJTMH: American Journal of Tropical Medicine and Hygiene)
• Efficacy and safety of alternative benznidazole and nifurtimox regimens for adults with chronic Trypanosoma cruzi infection (TESEO): an open-label, randomised, non-inferiority phase 2b trial (LANCET: Infectious Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #115 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/1 – 9/14/26.

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• Viral
• Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9–23 months in Uganda: a phase 4, single-blind, randomised clinical trial (The LANCET)
• Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization (Pediatrics)
• Beyond Koplik spots: aphthous-like ulcers as a novel enanthem in adolescent and adult measles (CMI: Clinical Microbiology and Infection)
• Bacterial
• A Ten-Year Trend of Antimicrobial Resistance in Pseudomonas aeruginosa From United States Medical Centers: Results From the INFORM Surveillance Program (2015–2024)(OFID)
• A Scenario-Based Survey of Clinician Recommendations for Follow-up Blood Cultures in Patients with Varying Risk of Persistent Gram-Negative Bacteremia (OFID)
• Should valve leaflet thickening be considered a characteristic lesion of infective endocarditis? (CID)
• Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart Association (AHA|ASA: Circulation)
• IDSA/ESCMID 2026 Consensus Statements on Staphylococcus aureus Bacteremia: Risk Stratification, Diagnostic Evaluation, and Management of Adults and Children (IDSA)
• Relationship between Antibiotic Prescription and Survival in Hospice (CID)
• Performance and Projected Impact of Synovial Fluid Polymerase Chain Reaction Testing for Patients Evaluated for Septic Arthritis (CID)
• Cefepime versus piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa pneumonia (CID)
• Cefepime and Mortality A Systematic Review and Bayesian Meta-Analysis (JAMA: OPEN Network)
• Global and regional burden of colorectal cancer potentially related to Helicobacter pylori exposure: a risk attribution modelling study (BMJ Journals: eGastroenterology)
• A randomized controlled trial of cefiderocol versus standard therapy for Gram-negative bacterial bloodstream infections: Benefit and risk assessment using DOOR and generalized pairwise comparisons (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• No survival benefit associated with antifungal therapy for respiratory Candida spp.: a single-center retrospective cohort study (OFID)
• The Role of 1-3-Beta-D-Glucan in Predicting Pneumocystis jirovecii Pneumonia in Immunocompromised Children (Journal of the Pediatric Infectious Diseases Society)
• Parasitic
• Miscellaneous
• Vaccination Coverage Among Adolescents Aged 13–17 Years — National Immunization Survey-Teen, United States, 2025 (CDC:MMWR)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #114 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/18 – 8/31/26.

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• Viral
• HPV Vaccination and Risk of Head and Neck Cancers: A Large Real-World Cohort Study (International Society for Infectious Diseases)
• Beyond the Acute Illness: Three Myths About Viral RespiratoryInfection (JID)
• Use of Nowcasting to Estimate Real-Time Transmission Trends During a Measles Outbreak — South Carolina, October 2025–March 202 (CDC: MMWR)
• IPOL (Package Insert)
• Effect of inactivated poliovirus vaccine on nasal mucosal immunity and pharyngeal shedding following novel oral poliovirus vaccine type 2 challenge: A randomized, open-label trial (JID)
• Bacterial
• Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis (NEJM)
• Clinical Practice Guidelines by Infectious Diseases Society of America 2025 Guidelines on Management and Treatment of Complicated Urinary Tract Infections–Introduction and Methods (CID)
• Society of America: 2025 Guideline on Management and Treatment of Complicated Urinary Tract Infections–Selection of Antibiotic Therapy for Complicated Urinary Tract Infections (CID)
• Clinical Practice Guidelines by Infectious Diseases Society of America: 2025 Guidelines on Management and Treatment of Complicated Urinary Tract Infections – Timing of Intravenous to Oral Antibiotics Transition for Complicated Urinary Tract Infections (CID)
• Clinical Practice Guidelines by Infectious Diseases Society of America (IDSA): 2025 Guidelines on Management and Treatment of Complicated Urinary Tract Infections–Duration of Antibiotics for Complicated UTI (CID)
• Infective Endocarditis in Solid Organ and Haematopoietic Stem Cell Transplant Recipients (E-IPA Study): a propensity-score-matched retrospective cohort study (CID)
• Evaluation of Changes in Staphylococcus and Enterococcus Resistance Following Reduced Restrictions on Daptomycin and Linezoli (OFID)
• Comparison of VPM1002 with BCG in the prevention of tuberculosis in newborn infants: a multicentre, double-blind, randomised, phase 3, non-inferiority trial (LANCET: Infectious Diseases)
• Fungal
• The Last of US Season 2 (YouTube)
• Containment of a Candidozyma auris Outbreak in an Acute Care Hospital using a Comprehensive Screening and Surveillance Program (CID)
• Molecular Evidence of Autochthonous Environmental Acquisition of Fonsecaea Pediatric Infection in the United States (OFID)
• Challenging the concept of uncomplicated candidemia for shorter courses of antifungal therapy (OFID)
• Parasitic
• Miscellaneous
• Reliability of Physical Examination Findings in Youths Diagnosed With Pneumonia (JAMA)
• Recombinant shingles vaccination and the risk of cardiovascular events (Nature Medicine)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #113 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/4 – 8/17/26.

Hosts: Daniel Griffin and Sara Dong

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• Viral
• Two-year durability of MVA-BN vaccine-induced antibodies and the risk of Mpox breakthrough infections among high-risk populations: a prospective, longitudinal study (CMI: Clinial Microbiology and Infection)
• Notes from the Field: Potential Infant HIV Exposure from Donated Breast Milk Received Through Social Media — Santa Clara County, California, May 2025–January 2026 (CDC: MMWR)
• Bacterial
• Associations Between QuantiFERON-TB Gold Plus IFNγ Concentrations and Progression to Symptomatic Tuberculosis in Global High-Burden TB Settings (OFID)
• Cefadroxil as Oral Transitional Therapy for Gram-Positive Bacteremia With or Without Non-Vertebral Osteomyelitis: A Multicenter Retrospective Cohort Study (OFID)
• Efficacy of beta-lactam monotherapy versus clindamycin or addition of metronidazole in peritonsillar abscess – an observational cohort study with a focus on Fusobacterium necrophorum (CMI: Clinial Microbiology and Infection)
• A novel RNA nucleic acid amplification test more accurately distinguishes active Clostridioides difficile infection from colonization (CID)
• The Clean Margin in Diabetic Foot Osteomyelitis: Conceptual Appeal, Practical Uncertainty (CID)
• Rising Incidence of New Delhi Metallo-β-Lactamase–Producing Carbapenem-Resistant Enterobacterales, 10 US Sites, 2018–2023 (OFID)
• Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Coccidioidomycosis Testing Among Patients Hospitalized With Community-Acquired Pneumonia (OFID)
• Parasitic
• Human Myiasis Resulting from Reemergence of Cochliomyia hominivorax Screwworm, Mexico, 2025–2026 (Emerging Infectious Diseases)
• The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa (Science)
• Clinical, molecular, and in vitro evidence of artemisinin partial resistance in Ethiopian Plasmodium falciparum: a prospective, multisite, surveillance (LANCET: Infectious Diseases)
• Miscellaneous
• What's in a Name? Etymology and History of Antibacterials and Antifungal (IOFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #112 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/20 – 8/3/26.

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• Viral
• The genomic identity of early smallpox in South America (Science)
• Telltale DNA: First direct evidence found that the Spanishbrought smallpox to the Inca (CIDRAP)
• Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment (NEJM)
• Early Transcriptional Signature in Chikungunya PredictsChronic Arthralgia and Reveals Deficient Antiviral Response (JID)
• Bacterial
• IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections (IDSA)
• Doxycycline in the treatment of outpatient mild community-acquired pneumonia: a propensity-matched retrospective cohort study (CMI: Clinical Microbiology and Infection)
• Detection of pathogens in the gut microbiome priorto bloodstream infection in children with acute myeloid leukemia or mature B-cell non-Hodgkin lymphoma (Journal of Pediatric Infectious Diseases Society)
• Fungal
• The Last of US Season 2 (YouTube)
• Active Surveillance for Invasive Mold Disease — Four Hospitals, Atlanta, Georgia, 2020–2024 (CDC: MMWR)
• Does the Evidence Support High-Dose Liposomal Amphotericin B in the Treatment of Mucormycosis? (JID)
• Miscellaneous
• Evaluation of the impact of a novel surgical handwashing method on reformation of microbial flora on surgeons' hands (Infection Control & Hospital Epidemiology)
• Association Between First MMR Vaccination Before Age 2 Years and Childhood Autism in a U.S. EHR Cohort of 2.5 Million Children (Journal of Pediatric Infectious Diseases Society)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #111 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/7 – 7/20/26.

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• Viral
• Impact of HIV-1 RNA Assay Selection on Low-Level Viremia and Clinical Trial Endpoint Interpretations (CID)
• Seroprevalence of Measles, Mumps, Rubella, and Varicella-Zoster Virus Antibodies—United States, 2017–March 2020 (JID)
• Concordance between nasopharyngeal swab and bronchoalveolar lavage PCR for respiratory viruses (CMI: Clinical Microbiology and Infection)
• Influenza vaccine effectiveness against outpatient acute respiratory illness with laboratory-confirmed influenza, United States, 2024–25 season (CID)
• Bacterial
• Clinical Impact of the BIOFIRE FILMARRAY Pneumonia Panel in the Veterans Affairs Healthcare System: A Difference-in-Differences Study (CID)
• Routine serial follow-up blood cultures after a negative result within 48 hours of methicillin-susceptible Staphylococcus aureus bacteremia: low yield, high cost (CID)
• Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia? (CID)
• Clinical Features of Clostridial Necrotizing Soft-Tissue Infections: Analysis of a Prospective Scandinavian Cohort Study(OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Molecular Epidemiology of Candidozyma auris Within a Case Cluster in North-Central Florida: Diverse Origins and Long-term Persistence ofStrain (OFID)
• Characteristics of Mortality in HIV-negative Cryptococcosis Patients: Analysis of a Cohort of 743 Patients (OFID)
• Parasitic
• Positive Strongyloides Serology: A Descriptive Analysis Across Geographically Distinct Academic Medical Centers (Transplant Infectious Diseases)
• Miscellaneous
• Community-acquired pneumonia: imperfect tests, imperfect clinicians or both? (CMI: Clinical Microbiology and Infection)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #110 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 6/23 – 7/6/26.

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• Viral
• Oseltamivir Resistance in Human Influenza A(H5N1) and A(H7N9) Infections: a mini review (OFID)
• Analysis of Viral Blips Through Week 192 of the DRIVE-FORWARD and DRIVE-AHEAD Phase 3 Studies of Doravirine-Based Regimens in Adults Living With Previously Untreated HIV-1 (OFID)
• Bacterial
• Impact of Multiplex PCR Blood-Culture Identification Panels on Clinical Outcomes, Antimicrobial Stewardship, and Economic Impact in US Hospitals: A Systematic Review and Meta-Analysis (OFID)
• Legionellosis Outbreaks Associated with Two Hotels — U.S. Virgin Islands, October 2024–April 2025 (CDC: MMWR)
• Impact of Methicillin Resistance on Outcomes of Staphylococcus aureus Bacteremia at a U.S. Center, 2023–2024 (OFID)
• Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections (JAMA:Open Network)
• Fungal
• The Last of US Season 2 (YouTube)
• Comparing rapid molecular and culture methods for detecting fungal contamination in healthcare environments (Infection Control and Hospital Epidemiology)
• Surveillance for Candida auris — United States, 2022–2024 (CDC: MMWR)
• Parasitic
• Alpha-gal Immunoglobulin E Seroprevalence Among Blood Donors — 10 States, 2024–2025
• (CDC: MMWR)
• Schistosomiasis vaccine SchistoShield induces functional immune memory responses in US and African populations (njp: Vaccines)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #109 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/4 – 6/22/26.

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• Viral
• CMV viraemia is associated with mortality among children with HIV starting antiretroviral therapy in sub-Saharan Africa (CID)
• Bacterial
• Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia(NEJM)
• A fatal case of Legionella micdadei prosthetic valve endocarditis diagnosed by plasma microbial cell-free DNA metagenomic sequencing (LANCET: Infectious Diseases)
• Legionnaires Disease Associated with a Private-Use Hot Tub in a Vacation Rental Property — New York, October 2024–April 2025 (CDC: MMWR)
• Notes from the Field: Case of Legionnaires Disease Associated with a Home Device Used to Mix Powdered Infant Formula — United States, 2025 (CDC:MMWR)
• Duration of antibiotic therapy for bacteremia in immune compromised hosts—a post hoc subgroup analysis of the BALANCErandomized clinical trial (CMI: Clinical Microbiology and Infection)
• FDA approves first oral carbapenem therapy for complicated urinary tract infections (FDA)
• Oral Tebipenem Matched IV antibiotic for complicated UTIs in Phase III Trial (MEDPAGE Today)
• US FDA approves GSK's oral antibiotic for drug-resistant UTIs (Reuters)
• Anti–Methicillin-Resistant Staphylococcus aureus (MRSA) Cephalosporins Plus Daptomycin as Initial Therapy for MRSA Bacteremia: Does a "Hit Hard and Fast" Strategy Improve Outcomes? (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Oral Wash PCR Improves the Diagnosis of Pneumocystis Pneumonia in Immunocompromised Patients Without HIV: A Prospective Multicenter Study (CID)
• Miscellaneous
• Foodborne Disease Outbreaks Associated with Marine Toxins — Foodborne Disease Outbreak Surveillance System, United States, 2011–2023 (CDC: MMWR)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #108 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/21 – 6/3/26.

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• Viral
• Performance of five mpox antigen-based rapid diagnostic tests tested on lesion swabs from patients with suspected mpox from the Kinshasa province of DR Congo: a diagnostic accuracy study (LANCET: Infectious Diseases)
• A Phase 3, Randomized Trial ofBulevirtide in Chronic Hepatitis D (NEJM)
• First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib (CMI: Clinical Microbiology and Infection)
• Chikungunya Vaccines for Travelers: Unanswered Pragmatic Questions Persist (JID)
• Bacterial
• Early Discontinuation of Empiric Antibiotics in Pediatric Haploidentical Hematopoietic Cell Transplant Recipients with Febrile Neutropenia (CID)
• Methicillin-Resistant Staphylococcus aureus Nasal Swab Utilization as a Predictor for Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections: A Systematic Review and Meta-analysis (OFID)
• Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin: A Randomized Controlled Trial (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Donor-derived and nosocomial-acquired Candida auris transmission involving solid organ transplant recipients (Infection Control and Hospital Epidemiology)
• Parasitic
• Development of a Phase 1 Cryptosporidiosis Controlled Human Challenge Model in Healthy Volunteers Using Current Good Manufacturing Practice Cryptosporidium Parvum Oocysts and Conducted Under an Investigational New Drug Application (JID)
• Miscellaneous
• Childhood VaccineHesitancy(NEJM)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #107 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/7 – 5/20/26.

Host: Daniel Griffin and Sarah Dong

Subscribe (free): Apple Podcasts, RSS, email

Become a patron of Puscast!

• Viral
• FDA Grants Accelerated Approval to Gilead's Hepcludex® (bulevirtide-gmod), the First and Only Approved Treatment for Chronic Hepatitis Delta Virus (HDV) (Gileadl)
• A Phase 3, Randomized Trial ofBulevirtide in Chronic Hepatitis D(NEJM)
• Study to Assess Efficacy and Safety of Bulevirtide in Participants With Chronic Hepatitis Delta (CHD) (NLM: ClinicalTrials.gov)
• Andes Hantavirus Outbreak on a Cruise Ship, 2026 (NEJM)
• Quick takes: Another hantavirus case, polio in 3 countries, NIAID head steps down (CIDRAP)
• Dolutegravir Reduces Human T-Cell Lymphotropic Virus Type 1 Proviral Load and Improves Neurological Outcomes in a Phase 2 Controlled Trial (CID)
• Dolutegravir Appears to Lower Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) Proviral Load: The Emerging Rational Approach to Treatment of HTLV-1–Associated Myelopathy (CID)
• Use of Dolutegravir for treatment of HTLV-1 (CID)
• Use of dolutegravir to treat people living with HTLV-1-associated myelopathy (HAM) (CID)
• Bacterial
• Urinary Tract Infection (UTI)-free and Recurrent UTI (rUTI)-Free Survivals Following Bladder Electrofulguration in Women With a History of Antibiotic-Refractory rUTI (OFID)
• Azithromycin for Preschoolers with Wheezing in the Emergency Department (JAMA)
• Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care (JAMA Internal Medicine)
• Fungal
• The Last of US Season 2 (YouTube)
• Changes in Epidemiology of Candidemia in the United States With a Focus on Candida auris (CID)
• Parasitic
• Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme (The LANCET)
• Ivermectin-Benzimidazole Prescribing Following Celebrity Endorsement (JAMA Network OPEN)
• Febrile Temperature Augents Ring-stage Plasmodium falciparum Adhesion to Brain Endothelial Cells (JID)
• An Increase in Imported Plasmodium vivax Malaria in New York City: Clinical and Demographic Trends Following Recent Migration (OFID)
• Miscellaneous
• The State of Physician Leadership (WittkKieffer)
• Infectious Diseases Fellowship Curriculum: IDSA Training Program Directors Community of Practice (TPDCOP), Curricular and Educational REsources Workgroup (CREW) (CID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.