On episode #79 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/10/25 – 4/23/25.

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• Viral
• An ancient Epstein-Barr virus genome recovered from a museum penis gourd from Papua (JID)
• Patterns of Decline in Measles, Mumps, and Rubella Neutralizing Antibodies and Protection Levels Through 10 Years After a Second and Third Dose of MMR Vaccine (OFID)
• Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo(NEJM)
• Bacterial
• Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay(Science Translational Medicine)
• New handheld device can diagnose TB without a lab in under an hour, its developers say(CIDRAP)
• Maternal mastitis and streptococcal toxic shock syndrome risk from breastfeeding children with scarlet fever (LANCET: Infectious Diseases)
• Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit(Infectious Diseases and Therapy)
• Bacteremia in Pediatric Solid Organ Transplant Recipients within 1 Year of Transplant(Transplant Infectious Disease)
• Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1) (LANCET)
• Consequences of Climate Change on the Emergence of Pathogenic, Environmentally Acquired Nontuberculous Mycobacteria (OFID)
• Addition of Macrolide Antibiotics for Hospital Treatment of Community-Acquired Pneumonia (JID)
• Point-of-Care Testingby Multiplex-PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation(Transplant Infectious Disease)
• Fungal
• The Last of US Season 2 (YouTube)
• Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome (Science Advances)
• Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis (JID)
• Parasitic
• Uganda launches largest malaria vaccine introduction to date(WHO: Uganda)
• Long-term follow-up of individuals with Chagas disease treated with posaconazole and benznidazole in a non-endemic region(CMI: Clinical Microbiology and Infection)
• Miscellaneous
• Monoclonal Antibodies From Children With Acute Kawasaki Disease Identify a Common Antigenic Target in Fatal Cases Over 5 Decades (Laboratory Investigation)
• Screwworm Cochliomyia hominivorax (Facebook)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #78 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/27/25 – 4/9/25.

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• Viral
• Demise of the Milwaukee protocol for rabies (CID)
• A natural experiment on the effect of herpes zoster vaccination on dementia (Nature)
• Taking a shot at dementia(microbeTV: TWiV)
• Recommendations from the 10th European Conference on Infections in Leukaemia for the management of cytomegalovirusin patients after allogeneic haematopoietic cell transplantation and other T-cell-engaging therapies (LANCET: Infectious Diseases)
• Epstein-Barr virus exposure precedes Crohn`s disease development (Gastroenterology aga)
• Bacterial
• Blujepa (gepotidacin) approved by US FDA for treatment of uncomplicated urinary tract infections (uUTIs) in female adults and paediatric patients 12 years of age and older (GSK)
• GSK wins FDA nod for first oral UTI antibiotic in almost 30 years(BioSpace)
• Efficacy and safety of individualised versus standard 10-day antibiotic treatment in children with febrile urinary tract infection (INDI-UTI): a pragmatic, open-label, multicentre, randomised, controlled, non-inferiority trial in Denmark (LANCET: Infectious Diseases)
• Frequency and severity of Myasthenia Gravis exacerbations associated with the use of ciprofloxacin, levofloxacin, and azithromycin (Muscle & Nerve)
• The cost of blood cultures: a barrier to diagnosis in low-income and middle-income countries
• (LANCET: Microbe)
• Rethinking blood culture (LANCET: Microbe)
• Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data and Outcomes(CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Cracks in the curriculum: the hidden deficiencies in fungal disease coverage in medical books (OFID)
• Kazachstania slooffiae fungemia: a case report and literature review on an emerging opportunistic pathogen in humans (OFID)
• Plasma microbial cell-free DNS metagenomic sequencing for diagnosis of invasive fungal diseases among high risk outpatient and inpatient immunocompromised hosts (CID)
• Parasitic
• Fatal Case of Splash Pad–Associated Naegleria fowleri Meningoencephalitis — Pulaski County, Arkansas, September 2023 (CDC: MMWR)
• Notes from the Field: Fatal Acanthamoeba Encephalitis in a patient who regularly used tap water in an electronic nasal irrigation device and a continuous positive airway pressure machine at home — new Mexico, 2023 (CDC: MMWR)
• Malaria (NEJM)
• Miscellaneous
• FDA grants marketing authorization of first home test for chlamydia, gonorrhea and trichomoniasis (FDA)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #77 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/13/25 – 3/26/25.

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• Viral
• Food is medicine for human immunodeficiency virus: improved health and hospitalizations in the changing health through food support (chefs-hiv) pragmatic randomized trial (JID)
• The epidemiology and burden of human parainfluenza virus hospitalizations in u.s. children (Journal of the Pediatric Infectious Diseases Society)
• Bacterial
• Epidemiology and outcomes of bloodstream infections in patients in a burns intensive care unit: an eight-year retrospective study(OFID)
• Prophylactic vancomycin in the primary prevention of clostridium difficile in allogeneic stem cell transplant(Transplant Infectious Disease)
• Incidence of scrub typhus in rural south India (NEJM)
• Antibiotic treatment for 7 versus 14 days in patients with bloodstream infections(NEJM)
• Blood Culture–Negative Endocarditis(Journal of the American Heart Association)
• Brucella suis Infection in Cardiac Implantable Device of Man Exposed to Feral Swine Meat, Florida, USA (CDC Emerging Infectious Diseases)
• Hyperbilirubinemia at hospitalization predicts nosocomial infection in decompensated cirrhosis (Hepatology Communicatons)
• Fungal
• The Last of US Season 2 (YouTube)
• Fungal Infections in People Who Use Drugs (OFID)
• IDSA 2025 guideline update on the treatment of asymptomatic histoplasma pulmonary nodules (histoplasmomas) and mild or moderate acute pulmonary histoplasmosis in adults, children, and pregnant people(IDSA: Infectisous Disease Society of America)
• Changing trends in the sources and volumes of clinical cultures with Candida auris at a large health system, 2019-2023 (American Journal of Infection Control)
• Diagnostic test accuracy of the Fungitell serum (1→3)-β-D-glucan assay for the diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis (CMI: Clinical Microbiology and Infection)
• Parasitic
• Impact of Strongyloides stercoralis Coinfection on Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis (OFID)
• Hematology thin smears perform equally to parasitology thick and thin blood smears for the diagnosis of Plasmodium and Babesia infections in a low prevalence setting (Journal of Clinical Microbiology)
• Notes from the Field: Rhodesiense Human African Trypanosomiasis (Sleeping Sickness) in a Traveler Returning from Zimbabwe — United States, August 2024 (CDC: MMWR)
• Miscellaneous
• The history of phage therapy LANCET: Infectious Diseases)
• Silence=death redux: infectious diseases, public health, and the imperative to resist (CID)
• Silence = Death, 1990(David Wojnarowicz Foundation)
• SILENCE=DEATH (B200KLYN Museaum)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #76 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 2/27/25 – 3/12/25.

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• Viral
• Trends in respiratory pathogen testing at us children’s hospitals (JAMA Network)
• Changes in respiratory viral testing before and after the covid-19 pandemic(JAMA Network)
• Expanding measles outbreak in the United States and guidance for the upcoming travel season (CDC Emergerncy Preparedness and Response)
• Measles cases and outbreaks (CDC Measles (Rubeola))
• Facts and myths about measles (LANCET: Infectious Diseases)
• Protective effects of recombinant zoster vaccine and antiviral therapy against cardiovascular disease following herpes zoster infection (JID)
• Chikungunya vaccine information for healthcare providers (CDC Chikungunya Virus)
• Factors to assess when considering use of chikungunya vaccine(CDC)
• Bacterial
• Should patients hospitalized forcommunity-acquired pneumonia be treated with additional antimicrobial agents directed against anaerobes? (American Journal of Therapeutics)
• Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy(Blood)
• Effectiveness of ampicillin/sulbactam versus ceftriaxone for the initial treatment of community-acquired pneumonia in older adults: a target trial emulation study(OFID)
• Male-partner treatment to prevent recurrence of bacterial vaginosis(NEJM)
• Fungal
• The Last of US Season 2 (YouTube)
• Activity of rezafungin against echinocandin non–wild type candida glabrata clinical isolates from a global surveillance program (OFID)
• Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study  (Intensive Care Medicine)
• Parasitic
• Human alveolar echinococcosis – global, regional and national annual incidence and prevalence rates (CMI: Clinical Microbiology and Infection)
• Dust to Diagnosis – with MSGERC (FEBRILE)
• The clinical picture caused by Fasciola gigantica: Analysis of 3,250 patients along the 1995–2019 countrywide spread in Vietnam (OFID)
• Miscellaneous
• Reprint of: From medical editors: a call to the global infectious diseases and clinical microbiology community (CMI: Clinical Microbiology and Infection)
• A hot topic: A climate-focused track for infectious disease fellowship (OFID)
• Are we being gaslit? A primer for recognizing corporate jargon to overcome gaslighting for the infectious disease workforce (CID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #75 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 2/13/25 – 2/26/25.

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• Viral
• VIMKUNYA (FDA)
• Co-infection of SARS‐CoV‐2 and influenza A/B among patients with COVID-19(BMC Infectious Diseases)
• Measles (Texas Health and Human Services)
• 2025 Measles outbreak guidelines (New Mexico Health)
• BTN: Beyond the Noise with Paul Offit (microbeTV)
• Rubeola response (febrile)
• Timing of influenza antiviral therapy and risk of death in adults hospitalized with influenza-associated pneumonia, influenza hospitalization surveillance network (FluSurv-NET), 2012–2019 (CID)
• Mother-child dyads living with HIV in the Western Cape, South Africa: undetectable = undetectable? (Journal of the International AIDS Society)
• Early impacts of the PEPFAR stop-work order: a rapid assessment(Journal of the International AIDS Society)
• Prevalence, clinical management, and outcomes of adults hospitalised with endemic arbovirus illness in southeast Europe (MERMAIDS-ARBO): a prospective observational study (LANCET: Infectious Diseases)
• Bacterial
• Effects of extended anaerobic antibiotic coverage on anaerobic bloodstream infection: A multisite retrospective stud (International Journal of Infectious Diseases)
• The effectiveness of newer Beta-Lactams for the treatment of antimicrobial-resistant gram-negative meningitis (CID)
• Treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a aeta-analysis of macrolides versus tetracycline (The Pediatric Infectious Disease Journal)
• Fungal
• The Last of US Season 2 (YouTube)
• Concordance of noninvasive plasma cell-free DNA With invasive diagnostics for diagnosis of invasive fungal disease (CID)
• Invasive fungal infections in patients with liver disease: immunological and clinical considerations for the intensive care unit(Intensive Care Medicine)
• Parasitic
• Epidemiologic Investigation of Protozoa and soil-transmitted helminths in Starr County, Texas (American J Trop Med and Hyg)
• Post-artesunate delayed hemolysis in African children with severe malaria: incidence, medical impact and prevention (CID)
• Miscellaneous
• Telehealth (Medicare.gov)
• Public comment: IDSA guideline on management and treatment of complicated urinary tract infections (IDSA)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #74 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/30/25 – 2/12/25.

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• Viral
• Global Impact of mass vaccination campaigns on circulating type 2 vaccine-derived poliovirus outbreaks (JID)
• Co-infection of SARS‐CoV‐2 and influenza A/B among patients with COVID-19 (BMC Infectious Diseases)
• Oseltamivir reduces 30-Day mortality in older adults with Influenza (OFID)
• Bacterial
• Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia (LANCET Respiratory Medicine)
• Rethinking antibiotic prophylaxis for spontaneous bacterial peritonitis in patients with cirrhosis (CID)
• Determining the optimal antibiotic duration for skin and soft tissue infections (Current Opinion in Infectious Diseases)
• The stealth and potentially fatal nature of Kingella kingae outbreaks in daycare facilities (OFID)
• Piperacillin/tazobactam vs. cefepime or carbapenems for the treatment of bloodstream infections due to bacteria producing chromosomal AmpC beta-lactamase (Infection)
• Is systemic dissemination of BCG following neonatal vaccination required for protection against Mycobacterium tuberculosis? (JID)
• Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study (eClinical Medicine)
• Fungal
• The Last of US Season 2 (YouTube)
• Developing mRNA lipid nanoparticle vaccine effective for cryptococcosisin a murine model (Vaccines)
• The araneopathogenic genus Gibellula (Cordycipitaceae: Hypocreales) in the British Isles, including a new zombie species on orb-weaving cave spiders (Metainae: Tetragnathidae) (Fungal Systematics and Evolution)
• Sensitivity of Coccidioides serologic tests among culture-proven coccidioidomycosis patients with hematological malignancy compared to a matched immunocompetent cohort (Medical Mycology)
• Parasitic
• New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine (LANCET: Infectious Diseases)
• Miscellaneous
• Remote practice of infectious diseases through telemedicine (OFID)
• Telemedicine offers solutions for the rural disparities in infectious disease (ID) care delivery (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #73 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/16/25 – 1/29/25.

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• Viral
• AGA clinical practice guideline on the prevention and treatment of hepatitis B virus reactivation (Gastroenterology)
• Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients (Nature Communications)
• Insect-specific RNA viruses detection in Field-Caught Aedes aegypti mosquitoes from Argentina using NGS technology (PLoS Neglected Tropical Diseases)
• Bacterial
• Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis (NEJM)
• Impact of antibiotic treatment and predictors for subsequent infections in multidrug-resistant Pseudomonas aeruginosa catheter-associated asymptomatic bacteriuria (American Journal of Infection Control)
• Identification of the skip phenomenon among patients With Staphylococcus lugdunensis infective endocarditis (OFID)
• Emergence of infective endocarditis due to Serratia spp. (OFID)
• Reduction of vancomycin-associated acute kidney injury with montelukast (JID)
• Fungal
• The Last of US Season 2 (YouTube)
• Pulmonary co-infection of Pneumocystis jirovecii and Aspergillus species (OFID)
• Impact of fluconazoleon outcomes of patients with primary pulmonary coccidioidomycosis (CID)
• Parasitic
• Comparative outcomes of Babesiosis in immunocompromised and non-immunocompromised hosts (CID)
• Miscellaneous
• Hidradenitis suppurativa (LANCET)
• A severe case associated with mixed infections of Pasteurella multocida, Bacteroides pyogenes and Fusobacterium necrophorum due to a snow leopard bite (CMI: Clinical Microbiology and Infection)
• INSIDE-OUT: Introduction of speakers at IDWeek events (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #72 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/2/25 – 1/15/25.

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• Viral
• Human infection with a novel tickborne Orthonairovirus species in China(NEJM)
• Antiviral medications for treatment ofnonsevere influenza(JAMA Network: JAMA Internal Medicine)
•  Xofluza (GoodRx)
• NoroSTATData Table (CDC Norovirus)
• The discovery of the 27-nm Norwalk virus: an historic perspective (JID)
• Why the “Ferrari of viruses” is surging through the northern hemisphere (Science)
• Bacterial
• Beta-lactams toxicity in the intensive care unit: an underestimatedcollateral damage?
• (Microorganims)
• What is the most effective antibiotic monotherapy for severe Pseudomonas aeruginosa infection? (CMI: Clinical Microbiology and Infection)
• Doxycycline postexposure prophylaxis and bacterial sexually tansmitted infections among individuals using HIV preexposure prophylaxis(JAMA Network: JAMA Internal Medicine)
• Fungal
• The Last of US Season 2 (YouTube)
• Epidemiology and prognostic factors associated with mold-positive blood cultures: 10-year data From a french prospective surveillance program (2012–2022) (CID)
• Parasitic
• Safety and efficacy of immunization with a late-liver-stage attenuated malaria parasite
• (NEJM)
• Dr. Glaucomflecken explains: late-liver-stage attenuated malaria vaccine (YouTube)
• Dr. Glaucomflecken X NEJM (YouTube)
• Albendazole–ivermectin co-formulation for the treatment of Trichuris trichiura and other soil-transmitted helminths: a randomised phase 2/3 trial (LANCET: Infectious Diseases)
• Miscellaneous
• A comparison of peripherally insertedcentral catheter materials(NEJM)
• Considering Islamic frameworks to infectious disease prevention (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #71 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 12/19/24 – 1/1/25.

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• Viral
• Routine detection of viruses through metagenomics: where do we stand? (ASTMH)
• Rapid selection of HIV-2 capsid mutations in salvage therapy with Lenacapavir-containing regime (CID)
• Bacterial
• Ancient genomes reveal a deep history of treponemal disease in the Americas (Nature)
• The utility of Interferon-γ release assays in the diagnosis of tuberculosis in patients With cancer(Transplant Infectious Disease)
• A meta-analysis of Levofloxacin for contacts of multidrug-resistant tuberculosis (NEJM Evidence)
• Tularemia— United States, 2011–2022 (CDC: MMWR)
• Incorporating incubation period distributions to precisely estimate the association between rainfall and Legionella infection (JID)
• Fungal
• The Last of US Season 2 (YouTube)
• Candida albicans recovered from persistent candidemia exhibit enhanced virulence traits (JID)
• Mapping the geographic distribution of dimorphic mycoses using a U.S. commercial insurance database (OFID)
• Comparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV – A systematic review and network meta-analysis of randomized controlled trials (CMI: Clinical Microbiology and Infection)
• Outbreak of Blastomycosis Among Paper Mill Workers — Michigan, November 2022–May 2023 (CDC: MMWR)
• Parasitic
• Acanthamoeba Infection in a hematopoietic cell transplant recipient: challenges in diagnosis, management, and source identification (Transplant Infectious Disease)
• Congenital toxoplasmosis: Fewer clinical signs at 3 years of age over the last 15 years but stable risk of materno-fetal transmission (CID)
• Miscellaneous
• Detection of prions in wild pigs (Sus scrofa) from areas with reported chronic wasting disease cases, United States (CDC Emerging Infectious Diseases)
• Addition of macrolide antibiotics for hospital treatment of community-acquired pneumonia (JID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #70 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 12/5/24 – 12/18/24.

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• Viral
• Epidemiology of Dengue— Puerto Rico, 2010–2024(CDC MMWR)
• Takeda Announces Voluntary Withdrawal of U.S. Biologics License Application (BLA) for Dengue Vaccine Candidate TAK-003(Takeda)
•  Global health and economic burden of chikungunya from 2011 to 2020 (BMJ Global Health)
• Bacterial
• Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis (JAMA Network)
• Say it ain’t Steno: a microbiology nudge comment leads to less treatment of Stenotrophomonas maltophilia respiratory colonization(Infection Control & Hospital Epidemiology)
• Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections in Pediatrics and Adults(JAMA Network)
• Epidemiology and Outcomes of Antibiotic De-escalation in Patients with Suspected Sepsis in US Hospitals (CID)
• Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study (LANCET Infectious Diseases)
• Bedaquiline Monotherapy for Multibacillary Leprosy (NEJM)
• Fungal
• The Last of US Season 2 (YouTube)
• Histoplasmosis Associated With Bat Guano Exposure in Cannabis Grower (OFID)
• Parasitic
• TWiV 1175: A hitchiker’s guide to virology(microbeTV)
• Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts (Nature Microbiology)
• Neurocysticercosis school outbreak in Belgium (LANCET)
• Miscellaneous
• Maintenance of Certification: Is a Knowledge-Based Assessment Really Necessary? (CID)
• Living happily ever after? The hidden health risks of Disney princesses (BMJ)
• How to transport a polar bear, and other idiosyncrasies in providing emergency medical services in the Arctic (BMJ)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.