Infectious Disease Puscast

On episode #118 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 10/13 – 10/26/26.

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• Viral
• Alimatravir Oral Once Monthly in Adults With Low Likelihood of HIV Exposure: A Randomized, Double-Blind, Placebo-Controlled Study (JID)
• Long-Acting Lenacapavir and Cabotegravir and Viral Suppression Among People With HIV (JAMA: Open Network)
• FDA Approves First-of-Its-Kind Chronic Hepatitis B Treatment (FDA)
• Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection (NEJM)
• Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial (Nature Medicine)
• Bacterial
• A Systematic Review and Network Meta-analysis of Empirical Antibiotics for Complicated Urinary Tract Infections (OFID)
• Cephalexin 500 mg Four Times Daily vs. 1000 mg Three Times Daily for the Treatment of Uncomplicated Cellulitis (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Performance of the Urinary MycoMEIA Aspergillus Assay as an Aid to Diagnose Invasive Aspergillosis (CID)
• Emergence of pan-drug resistant Candidozyma auris in Kenya, the second globally documented case(Scientific Reports)
• Parasitic
• Artificial Intelligence–Supported Automated Microscopy for Malaria Diagnosis: A Multicenter Study (CID)
• Decentralized Diagnostic Platform, miLab™ (noul)
• Mapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply (CID)
• Locally Acquired Malaria Cases Identified in the United States (CDC: Emergency Preparedness and Response)
• ARTESUNATE FOR INJECTION (AMIVAS)
• Availability of IV Artesunate for Severe Malaria (CID)
• Miscellaneous
• Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis (NEJM)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #117 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/29 – 10/12/26.

Hosts: Daniel Griffin and Sara Dong

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• Viral
• Influenza Vaccine Effectiveness Against Influenza A–Associated Hospitalization and Severe In-Hospital Outcomes Among Adults in the United States, 2024–2025 (CID
• Risk Factors for Hypoxia, Mechanical Ventilation, and Mortality in Lung Transplant Recipients Hospitalized with Respiratory Syncytial Virus: A Multicenter International Cohort Study (OFID)
• Bacterial
• R.E.M. – It's The End Of The World (YouTube)
• Mandatory infectious diseases consultation and consensus approach effective at lowering antibiotic duration in uncomplicated gram-negative bacteremia (Journal of Gastroenterology and Hepatology)
• Air contamination and cross-room transmission of carbapenem resistant Acinetobacter baumannii in ICU (Antimicrobial Stewardship & Healthcare Epidemiology)
• Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria (Nature Communications)
• Clinical Practice Guideline for the Diagnosis and Treatment of Urinary Tract Infection in Children From 8 Days to 5 Years of Age (Pediatrics)
• Shorter Antibiotic Duration for Pseudomonas Bacteremia: A Call for Future Trials (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Impact of a Large-Scale Mold Intervention in Public Housing on Asthma Emergency Department Visits (American Journal of Respiratory and Critical Care Medicine)
• A Candid Appraisal of Repeat Blood Cultures in Candidemia—Missed Detection or Incident Infection? (CID)
• Notes from the Field: Molecular Detections of Cladophialophora bantiana at a Clinical Reference Laboratory — United States, 2009–2026 (CDC: MMWR)
• Histoplasmosis in Pregnancy: A Review and Patient Perspective (OFID)
• Parasitic
• Flubendazole reduces emerging Dracunculus medinensis in dogs in Chad: Results from a two-year study (PLoS Neglected Tropical Diseases)
• Toxoplasma Transmission to the Fetus during the Periconceptional Period (AJTMH: American Journal of Tropical Medicine and Hygiene)
• Clinical and Laboratory Dynamics of Bear Meat-Associated Trichinellosis in Hokkaido, Japan (AJTMH: American Journal of Tropical Medicine and Hygiene)
• Clinical significance of Dientamoeba fragilis and Blastocystis: Lessons from clinical trials, cohort studies, and faecal microbiota transplantation — a narrative review (CMI: Clinical Microbiology and Infection)
• Miscellaneous
• A consensus-based guideline for personalized bacteriophage therapy (Nature Medicine)
• Diagnosis and Management of Infectious Encephalitis in Adults: Guidelines From the European Academy of Neurology and European Society of Clinical Microbiology and Infectious Diseases (European Journal of Neurology)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #116 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/16 – 9/21/26.

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• Viral
• Oya Virus in a Patient with Severe Hepatitis, Enteritis, and Coagulopathy (NEJM)
• Two Versus One COVID-19 Vaccine Dose After Prior SARS-CoV-2 Infection: A Nationwide Retrospective Cohort Study (OFID)
• Comparison of Silevimig, a Novel Bispecific Anti-Rabies Monoclonal Antibody, with Human Rabies Immunoglobulin for Post-Exposure Prophylaxis: A Phase III, Randomized, Double-Blind, Non-Inferiority Trial (CID)
• Bacterial
• R.E.M. – It's The End Of The World (YouTube)
• Companion Animals Harbour Globally Circulating Human-Associated Klebsiella pneumoniae Lineages and High-Risk Antimicrobial Resistance Clones (Transboundary and Emerging Diseases)
• Air contamination and cross-room transmission of carbapenem resistant Acinetobacter baumannii in ICU (American Journal of Infection Control)
• Economic Outcomes of Dalbavancin versus Standard Therapy in Staphylococcus aureus Bacteremia in the DOTS Randomized Clinical Trial (CID)
• Cephalexin Model-Informed Dosing Recommendations for Severe Infections: A Pooled Pharmacokinetic Analysis From Infancy to Adulthood (OFID)
• Initial Carbapenem Choice Versus Sustained Single-Group Therapy in the Albumin-Carbapenem Interaction (CID)
• Identification and Quantification of Pathogens in Pleural Fluid from Children with Complicated Pneumonia using the BioFire® FilmArray® Pneumonia Panel (Journal of Pediatric Infectious Diseases Society)
• Effectiveness of oral care for the prevention of non-ventilator hospital-acquired pneumonia (HAPPEN): a multicentre, stepped-wedge, cluster-randomised trial in Australia (LANCET: Infectious Diseases)
• Fungal
• The Last of US Season 2 (YouTube)
• Health Economic Analysis of the AMBITION Protocol for Human Immunodeficiency Virus–Associated Cryptococcal Meningitis in the United States (CID)
• Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (NEJM)
• Parasitic
• Vampire bats in Belize harbor multiple Trypanosoma cruzi genotypes: Implications for parasite transmission at the wildlife–domestic–human interface (PLoS Neglected Tropical Diseases)
• Community-acquired coinfections in adults with severe imported malaria: a systematic review and meta-analysis (CMI: Clincial Microbiology and Infection)
• Treatment for Leishmaniasis using liposomal amphotericin for immune compromised patients (in Portguese(Brazil.gov))
• Reactivation of Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Undergoing Tocilizumab Treatment (AJTMH: American Journal of Tropical Medicine and Hygiene)
• Efficacy and safety of alternative benznidazole and nifurtimox regimens for adults with chronic Trypanosoma cruzi infection (TESEO): an open-label, randomised, non-inferiority phase 2b trial (LANCET: Infectious Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #115 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/1 – 9/14/26.

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• Viral
• Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9–23 months in Uganda: a phase 4, single-blind, randomised clinical trial (The LANCET)
• Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization (Pediatrics)
• Beyond Koplik spots: aphthous-like ulcers as a novel enanthem in adolescent and adult measles (CMI: Clinical Microbiology and Infection)
• Bacterial
• A Ten-Year Trend of Antimicrobial Resistance in Pseudomonas aeruginosa From United States Medical Centers: Results From the INFORM Surveillance Program (2015–2024)(OFID)
• A Scenario-Based Survey of Clinician Recommendations for Follow-up Blood Cultures in Patients with Varying Risk of Persistent Gram-Negative Bacteremia (OFID)
• Should valve leaflet thickening be considered a characteristic lesion of infective endocarditis? (CID)
• Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart Association (AHA|ASA: Circulation)
• IDSA/ESCMID 2026 Consensus Statements on Staphylococcus aureus Bacteremia: Risk Stratification, Diagnostic Evaluation, and Management of Adults and Children (IDSA)
• Relationship between Antibiotic Prescription and Survival in Hospice (CID)
• Performance and Projected Impact of Synovial Fluid Polymerase Chain Reaction Testing for Patients Evaluated for Septic Arthritis (CID)
• Cefepime versus piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa pneumonia (CID)
• Cefepime and Mortality A Systematic Review and Bayesian Meta-Analysis (JAMA: OPEN Network)
• Global and regional burden of colorectal cancer potentially related to Helicobacter pylori exposure: a risk attribution modelling study (BMJ Journals: eGastroenterology)
• A randomized controlled trial of cefiderocol versus standard therapy for Gram-negative bacterial bloodstream infections: Benefit and risk assessment using DOOR and generalized pairwise comparisons (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• No survival benefit associated with antifungal therapy for respiratory Candida spp.: a single-center retrospective cohort study (OFID)
• The Role of 1-3-Beta-D-Glucan in Predicting Pneumocystis jirovecii Pneumonia in Immunocompromised Children (Journal of the Pediatric Infectious Diseases Society)
• Parasitic
• Miscellaneous
• Vaccination Coverage Among Adolescents Aged 13–17 Years — National Immunization Survey-Teen, United States, 2025 (CDC:MMWR)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #114 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/18 – 8/31/26.

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• Viral
• HPV Vaccination and Risk of Head and Neck Cancers: A Large Real-World Cohort Study (International Society for Infectious Diseases)
• Beyond the Acute Illness: Three Myths About Viral RespiratoryInfection (JID)
• Use of Nowcasting to Estimate Real-Time Transmission Trends During a Measles Outbreak — South Carolina, October 2025–March 202 (CDC: MMWR)
• IPOL (Package Insert)
• Effect of inactivated poliovirus vaccine on nasal mucosal immunity and pharyngeal shedding following novel oral poliovirus vaccine type 2 challenge: A randomized, open-label trial (JID)
• Bacterial
• Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis (NEJM)
• Clinical Practice Guidelines by Infectious Diseases Society of America 2025 Guidelines on Management and Treatment of Complicated Urinary Tract Infections–Introduction and Methods (CID)
• Society of America: 2025 Guideline on Management and Treatment of Complicated Urinary Tract Infections–Selection of Antibiotic Therapy for Complicated Urinary Tract Infections (CID)
• Clinical Practice Guidelines by Infectious Diseases Society of America: 2025 Guidelines on Management and Treatment of Complicated Urinary Tract Infections – Timing of Intravenous to Oral Antibiotics Transition for Complicated Urinary Tract Infections (CID)
• Clinical Practice Guidelines by Infectious Diseases Society of America (IDSA): 2025 Guidelines on Management and Treatment of Complicated Urinary Tract Infections–Duration of Antibiotics for Complicated UTI (CID)
• Infective Endocarditis in Solid Organ and Haematopoietic Stem Cell Transplant Recipients (E-IPA Study): a propensity-score-matched retrospective cohort study (CID)
• Evaluation of Changes in Staphylococcus and Enterococcus Resistance Following Reduced Restrictions on Daptomycin and Linezoli (OFID)
• Comparison of VPM1002 with BCG in the prevention of tuberculosis in newborn infants: a multicentre, double-blind, randomised, phase 3, non-inferiority trial (LANCET: Infectious Diseases)
• Fungal
• The Last of US Season 2 (YouTube)
• Containment of a Candidozyma auris Outbreak in an Acute Care Hospital using a Comprehensive Screening and Surveillance Program (CID)
• Molecular Evidence of Autochthonous Environmental Acquisition of Fonsecaea Pediatric Infection in the United States (OFID)
• Challenging the concept of uncomplicated candidemia for shorter courses of antifungal therapy (OFID)
• Parasitic
• Miscellaneous
• Reliability of Physical Examination Findings in Youths Diagnosed With Pneumonia (JAMA)
• Recombinant shingles vaccination and the risk of cardiovascular events (Nature Medicine)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #113 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/4 – 8/17/26.

Hosts: Daniel Griffin and Sara Dong

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• Viral
• Two-year durability of MVA-BN vaccine-induced antibodies and the risk of Mpox breakthrough infections among high-risk populations: a prospective, longitudinal study (CMI: Clinial Microbiology and Infection)
• Notes from the Field: Potential Infant HIV Exposure from Donated Breast Milk Received Through Social Media — Santa Clara County, California, May 2025–January 2026 (CDC: MMWR)
• Bacterial
• Associations Between QuantiFERON-TB Gold Plus IFNγ Concentrations and Progression to Symptomatic Tuberculosis in Global High-Burden TB Settings (OFID)
• Cefadroxil as Oral Transitional Therapy for Gram-Positive Bacteremia With or Without Non-Vertebral Osteomyelitis: A Multicenter Retrospective Cohort Study (OFID)
• Efficacy of beta-lactam monotherapy versus clindamycin or addition of metronidazole in peritonsillar abscess – an observational cohort study with a focus on Fusobacterium necrophorum (CMI: Clinial Microbiology and Infection)
• A novel RNA nucleic acid amplification test more accurately distinguishes active Clostridioides difficile infection from colonization (CID)
• The Clean Margin in Diabetic Foot Osteomyelitis: Conceptual Appeal, Practical Uncertainty (CID)
• Rising Incidence of New Delhi Metallo-β-Lactamase–Producing Carbapenem-Resistant Enterobacterales, 10 US Sites, 2018–2023 (OFID)
• Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Coccidioidomycosis Testing Among Patients Hospitalized With Community-Acquired Pneumonia (OFID)
• Parasitic
• Human Myiasis Resulting from Reemergence of Cochliomyia hominivorax Screwworm, Mexico, 2025–2026 (Emerging Infectious Diseases)
• The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa (Science)
• Clinical, molecular, and in vitro evidence of artemisinin partial resistance in Ethiopian Plasmodium falciparum: a prospective, multisite, surveillance (LANCET: Infectious Diseases)
• Miscellaneous
• What's in a Name? Etymology and History of Antibacterials and Antifungal (IOFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #112 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/20 – 8/3/26.

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• Viral
• The genomic identity of early smallpox in South America (Science)
• Telltale DNA: First direct evidence found that the Spanishbrought smallpox to the Inca (CIDRAP)
• Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment (NEJM)
• Early Transcriptional Signature in Chikungunya PredictsChronic Arthralgia and Reveals Deficient Antiviral Response (JID)
• Bacterial
• IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections (IDSA)
• Doxycycline in the treatment of outpatient mild community-acquired pneumonia: a propensity-matched retrospective cohort study (CMI: Clinical Microbiology and Infection)
• Detection of pathogens in the gut microbiome priorto bloodstream infection in children with acute myeloid leukemia or mature B-cell non-Hodgkin lymphoma (Journal of Pediatric Infectious Diseases Society)
• Fungal
• The Last of US Season 2 (YouTube)
• Active Surveillance for Invasive Mold Disease — Four Hospitals, Atlanta, Georgia, 2020–2024 (CDC: MMWR)
• Does the Evidence Support High-Dose Liposomal Amphotericin B in the Treatment of Mucormycosis? (JID)
• Miscellaneous
• Evaluation of the impact of a novel surgical handwashing method on reformation of microbial flora on surgeons' hands (Infection Control & Hospital Epidemiology)
• Association Between First MMR Vaccination Before Age 2 Years and Childhood Autism in a U.S. EHR Cohort of 2.5 Million Children (Journal of Pediatric Infectious Diseases Society)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #111 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/7 – 7/20/26.

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• Viral
• Impact of HIV-1 RNA Assay Selection on Low-Level Viremia and Clinical Trial Endpoint Interpretations (CID)
• Seroprevalence of Measles, Mumps, Rubella, and Varicella-Zoster Virus Antibodies—United States, 2017–March 2020 (JID)
• Concordance between nasopharyngeal swab and bronchoalveolar lavage PCR for respiratory viruses (CMI: Clinical Microbiology and Infection)
• Influenza vaccine effectiveness against outpatient acute respiratory illness with laboratory-confirmed influenza, United States, 2024–25 season (CID)
• Bacterial
• Clinical Impact of the BIOFIRE FILMARRAY Pneumonia Panel in the Veterans Affairs Healthcare System: A Difference-in-Differences Study (CID)
• Routine serial follow-up blood cultures after a negative result within 48 hours of methicillin-susceptible Staphylococcus aureus bacteremia: low yield, high cost (CID)
• Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia? (CID)
• Clinical Features of Clostridial Necrotizing Soft-Tissue Infections: Analysis of a Prospective Scandinavian Cohort Study(OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Molecular Epidemiology of Candidozyma auris Within a Case Cluster in North-Central Florida: Diverse Origins and Long-term Persistence ofStrain (OFID)
• Characteristics of Mortality in HIV-negative Cryptococcosis Patients: Analysis of a Cohort of 743 Patients (OFID)
• Parasitic
• Positive Strongyloides Serology: A Descriptive Analysis Across Geographically Distinct Academic Medical Centers (Transplant Infectious Diseases)
• Miscellaneous
• Community-acquired pneumonia: imperfect tests, imperfect clinicians or both? (CMI: Clinical Microbiology and Infection)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #110 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 6/23 – 7/6/26.

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• Viral
• Oseltamivir Resistance in Human Influenza A(H5N1) and A(H7N9) Infections: a mini review (OFID)
• Analysis of Viral Blips Through Week 192 of the DRIVE-FORWARD and DRIVE-AHEAD Phase 3 Studies of Doravirine-Based Regimens in Adults Living With Previously Untreated HIV-1 (OFID)
• Bacterial
• Impact of Multiplex PCR Blood-Culture Identification Panels on Clinical Outcomes, Antimicrobial Stewardship, and Economic Impact in US Hospitals: A Systematic Review and Meta-Analysis (OFID)
• Legionellosis Outbreaks Associated with Two Hotels — U.S. Virgin Islands, October 2024–April 2025 (CDC: MMWR)
• Impact of Methicillin Resistance on Outcomes of Staphylococcus aureus Bacteremia at a U.S. Center, 2023–2024 (OFID)
• Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections (JAMA:Open Network)
• Fungal
• The Last of US Season 2 (YouTube)
• Comparing rapid molecular and culture methods for detecting fungal contamination in healthcare environments (Infection Control and Hospital Epidemiology)
• Surveillance for Candida auris — United States, 2022–2024 (CDC: MMWR)
• Parasitic
• Alpha-gal Immunoglobulin E Seroprevalence Among Blood Donors — 10 States, 2024–2025
• (CDC: MMWR)
• Schistosomiasis vaccine SchistoShield induces functional immune memory responses in US and African populations (njp: Vaccines)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #109 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/4 – 6/22/26.

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• Viral
• CMV viraemia is associated with mortality among children with HIV starting antiretroviral therapy in sub-Saharan Africa (CID)
• Bacterial
• Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia(NEJM)
• A fatal case of Legionella micdadei prosthetic valve endocarditis diagnosed by plasma microbial cell-free DNA metagenomic sequencing (LANCET: Infectious Diseases)
• Legionnaires Disease Associated with a Private-Use Hot Tub in a Vacation Rental Property — New York, October 2024–April 2025 (CDC: MMWR)
• Notes from the Field: Case of Legionnaires Disease Associated with a Home Device Used to Mix Powdered Infant Formula — United States, 2025 (CDC:MMWR)
• Duration of antibiotic therapy for bacteremia in immune compromised hosts—a post hoc subgroup analysis of the BALANCErandomized clinical trial (CMI: Clinical Microbiology and Infection)
• FDA approves first oral carbapenem therapy for complicated urinary tract infections (FDA)
• Oral Tebipenem Matched IV antibiotic for complicated UTIs in Phase III Trial (MEDPAGE Today)
• US FDA approves GSK's oral antibiotic for drug-resistant UTIs (Reuters)
• Anti–Methicillin-Resistant Staphylococcus aureus (MRSA) Cephalosporins Plus Daptomycin as Initial Therapy for MRSA Bacteremia: Does a "Hit Hard and Fast" Strategy Improve Outcomes? (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Oral Wash PCR Improves the Diagnosis of Pneumocystis Pneumonia in Immunocompromised Patients Without HIV: A Prospective Multicenter Study (CID)
• Miscellaneous
• Foodborne Disease Outbreaks Associated with Marine Toxins — Foodborne Disease Outbreak Surveillance System, United States, 2011–2023 (CDC: MMWR)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.