RheumMadness Rheumatology Podcast

5.8 B-Cell Breakaway


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In this episode we discuss obinutuzumab for lupus nephritis and anti-CD19 CAR T Cell therapy for autoimmune rheumatic disease.   


Links to the B-Cell Breakaway Scouting Reports:

  • Obinutuzumab in lupus nephritis, by the University of Michigan Adult Rheumatology Fellowship Program
  • CD-19 CAR T-cell therapy, by the Vanderbilt University Adult Rheumatology Fellowship Program
  • STRAP trial, by the Emerging EULAR Network (EMEUNET)


Links to theMednet.org Q&As about this region:

  • In the treatment of lupus nephritis, which patients may benefit from the use of rituximab or other B-cell depleting agents during induction?
  • What are the potential barriers to the widespread use of obinutuzumab in proliferative lupus nephritis?
  • How do you envision incorporating CAR-T therapy into your clinical practice?
  • Does synovial biopsy provide diagnostic value in undifferentiated inflammatory arthritis?


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Intro/outro music: Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/

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