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đź§ Can a simple blood test tell us when Alzheimer's symptoms will begin?
A new Nature Medicine study introduces a plasma p-tau217 "molecular clock" that estimates time to symptom onset with an error margin of ~3–4 years. By modeling the rise of phosphorylated tau in cognitively unimpaired individuals, investigators move from predicting if to predicting when.
⏳ Implication: smarter prevention trials, earlier intervention windows, and biologically timed enrollment.
⚠️ Not ready for routine screening—but a compelling proof of concept.
The era of temporal precision in neurodegeneration may have begun.
By Dr RR Baliga, MD, MBA5
66 ratings
đź§ Can a simple blood test tell us when Alzheimer's symptoms will begin?
A new Nature Medicine study introduces a plasma p-tau217 "molecular clock" that estimates time to symptom onset with an error margin of ~3–4 years. By modeling the rise of phosphorylated tau in cognitively unimpaired individuals, investigators move from predicting if to predicting when.
⏳ Implication: smarter prevention trials, earlier intervention windows, and biologically timed enrollment.
⚠️ Not ready for routine screening—but a compelling proof of concept.
The era of temporal precision in neurodegeneration may have begun.

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