📘 New NEJM Evidence for the 2025–26 Vaccine Season is out—and it delivers clarity at a time we need it most.

The systematic review of 511 studies shows strong, consistent protection against hospitalization from Covid-19, RSV, and Influenza, with reassuring safety profiles across age groups. 💉🛡️

Key insights: improved VE for updated Covid-19 strains, high efficacy of maternal RSV vaccination and nirsevimab for infants, and solid influenza performance. 📊👶

A valuable guide for clinicians, health systems, and policymakers as we prepare for the upcoming respiratory season. 🌐🏥

New Lancet Seminar on heart failure with reduced ejection fraction.

💓📘, this videocast walks listeners through the essentials of diagnosis, natriuretic peptides, imaging pathways, and the four foundational therapies shaping modern heart failure care.

It's a clear, evidence-driven journey—designed to inform, clarify, and elevate bedside practice.

Tune in to explore the science, the strategy, and the future of treating HFrEF. 🫀🔬✨

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🔍💓 Chronic Coronary Artery Disease: Seeing What Matters Before It Hurts

Just finished reviewing the 2025 Lancet paper on contemporary non-invasive imaging for chronic CAD, and the message is striking: how we see the heart shapes how well we save it.

From CT angiography that unmasks non-obstructive plaque 🖥️➡️🫀 to stress PET/CMR that maps true ischemia under load 💨📊, multimodality imaging is redefining diagnosis, risk, and long-term outcomes.

The evidence is clear: better imaging leads to better prevention—and in many cases, fewer invasive procedures and fewer missed opportunities for early therapy.

In an era of rising cardiometabolic risk, precision imaging isn't just a tool—it's a commitment to catching disease in its "quiet" phase and protecting patients long before symptoms speak.

Science, clarity, prevention. 🔬✨❤️

Exploring David Hume 🧠✨

Just revisited David Hume's extraordinary contributions to modern thought — a reminder of how deeply empiricism, skepticism, and the science of human nature shape our intellectual world. His insights on causation, the limits of reason, and the power of moral sentiment continue to resonate across philosophy, psychology, economics, and evidence-based decision-making. 🌍📚

Hume challenges us to look closely, question boldly, and reason with humility — a timeless guide for scholars, clinicians, and leaders navigating uncertainty. 🔍💡

#Philosophy #Hume #Empiricism #HumanUnderstanding #Enlightenment

The U.S. heart failure landscape is transforming—and fast. 🫀📊

A new JACC analysis reveals a 35-year shift from ischemic to metabolic drivers of heart failure, with obesity, dysglycemia, and chronic kidney disease rising sharply, even as blood pressure, cholesterol, smoking, and myocardial infarction decline. 📉⚖️

These trends demand a new generation of HF trials—more inclusive, prevention-focused, metabolism-centered, and designed to capture outcomes beyond cardiovascular death. 🚀🧬

A powerful reminder: heart failure is not inevitable—but the way we study and prevent it must evolve. 🌅💡

🧬⏳ New Insights into Organ-Specific Aging! 🧠❤️🩺

Just explored a remarkable Nature Aging study showing how organ-specific proteomic clocks can forecast disease, cognitive decline, and even longevity with impressive precision. These clocks—built from >2,900 plasma proteins—reveal that the brain, kidney, and arteries age on their own timelines, each carrying unique clues about future health.

What struck me most is how brain aging outperforms traditional risk markers, predicting dementia even after accounting for age, APOE genotype, and cognitive scores. A powerful reminder that biological age isn't a single number—it's a symphony of organ-specific rhythms. 🎼

Exciting implications for precision medicine, early detection, and preventive cardiometabolic and neurodegenerative care.

Science that helps us see aging not as fate, but as a map. 🗺️✨

Respiratory vaccines are not just infection-fighters—they're cardiovascular protectors. 💉🫀

The 2025 JACC Consensus reminds us that influenza, pneumococcal, COVID-19, RSV, and zoster vaccines reduce MI, HF decompensation, hospitalizations, and death in our most vulnerable patients.

As clinicians, we hold the power to translate evidence into prevention: strong recommendations, simple pathways, and clear conversations can save lives long before interventions do. 🌟

Vaccinate to protect the heart. Shield to preserve life. Prevent to empower patients. ❤️‍🩹

#Cardiology #Vaccination #HeartHealth #JACC #Prevention #PublicHealth

The latest JAMA article on keratinocyte carcinomas 🌞—a timely reminder that BCC and cSCC remain the world's most common cancers, with more than 5.4 million cases annually in the US alone .

The review highlights essential updates in epidemiology, high-risk features, prevention, and evidence-based management, especially the role of sun protection, actinic keratosis treatment, and risk-stratified surgical care 🔬⚕️. A great resource for clinicians committed to early detection, thoughtful treatment, and lifelong surveillance of at-risk patients 👀🛡️.

If you work in dermatology, oncology, primary care, or population health, this is well worth your time 📚✨

🚨 Food Anaphylaxis: New Mechanisms Unveiled 🍽️🧬

A superb NEJM review highlights how cysteinyl leukotrienes act as gatekeepers in the gut—opening antigen passages, expanding mast cells, and amplifying the risk of oral anaphylaxis.

The work elegantly bridges basic lipid biology with real-world food allergy challenges, and points toward new preventive strategies beyond current IgE-based therapies.

🔍 A must-read for clinicians, scientists, and anyone navigating severe food allergies.

🌿 What does the evidence really say about medical cannabis?

A new JAMA review highlights a clear message: cannabis helps few conditions—and harms may outweigh benefits for many.

📉 Small benefit for nausea

⚡ Moderate benefit for select pediatric seizures

💊 Limited evidence for pain, insomnia, or psychiatric use

❤️ Risks rise with high-potency products, especially for heart and mental health.

🧭 Clinicians: guide with evidence, screen carefully, use lowest-risk options.