The brain's "skull drains" are far from passive plumbing. In Nature (2026), Monaghan et al. show that dural venous sinuses actively constrict, dilate, and even rearrange endothelial borders in a phenomenon called "ruffling" to support immune surveillance. RAMP1 regulates vasomotion. RAMP2 regulates immune boundary dynamics. Blocking RAMP2 impairs antiviral defense. The meninges are not coverings. They are regulated neuroimmune interfaces. 🧠🛡️

The brain's "skull drains" are far from passive plumbing. In Nature (2026), Monaghan et al. show that dural venous sinuses actively constrict, dilate, and even rearrange endothelial borders in a phenomenon called "ruffling" to support immune surveillance. RAMP1 regulates vasomotion. RAMP2 regulates immune boundary dynamics. Blocking RAMP2 impairs antiviral defense. The meninges are not coverings. They are regulated neuroimmune interfaces. 🧠🛡️

The brain's "skull drains" are far from passive plumbing. In Nature (2026), Monaghan et al. show that dural venous sinuses actively constrict, dilate, and even rearrange endothelial borders in a phenomenon called "ruffling" to support immune surveillance. RAMP1 regulates vasomotion. RAMP2 regulates immune boundary dynamics. Blocking RAMP2 impairs antiviral defense. The meninges are not coverings. They are regulated neuroimmune interfaces. 🧠🛡️

The brain's "skull drains" are far from passive plumbing.

"Got Knowledge Doc" Podkast with Dr. RR Baliga

The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond.

Each episode delves into topics such as cardiology, precision medicine, artificial intelligence in healthcare, epigenetics, and medical ethics—making complex advancements accessible and relevant to clinical practice. Importantly, this podcast is purely educational and does not provide medical advice or clinical opinions.

Join Dr. Baliga and his esteemed guests as they navigate the evolving landscape of medical knowledge, empowering healthcare professionals with evidence-based insights that shape the future of patient care.

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Natural Sciences

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each episode delves into topics such as cardiology, precision medicine, artificial intelligence in healthcare, epigenetics, and medical ethics—making complex advancements accessible and relevant to clinical practice. Importantly, this podcast is purely educational and does not provide medical advice or clinical opinions. Join Dr. Baliga and his esteemed guests as they navigate the evolving landscape of medical knowledge, empowering healthcare professionals with evidence-based insights that shape the future of patient care.

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The brain's "skull drains" are far from passive plumbing.

The brain's "skull drains" are far from passive plumbing.

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