Proton pump inhibitors (PPIs) are among the 10 most widely prescribed medications, but PPI overuse has been associated with adverse events. So what is the best advice for de-prescribing PPIs, and which of our patients should remain on PPIs? Find out the answers to these and other key questions with Dr. Peter Buch and Dr. Laura Targownik, who’s the lead author of the American Gastroenterological Association’s Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors.