In "A Three Act Play," Dr. Osterholm and Chris Dall discuss the trajectory of the pandemic in the U.S. and around the world, President Biden's recent comments on the state of the pandemic, and the potential threat posed by many of the emerging SARS-CoV-2 variants. Dr. Osterholm also shares the latest information on the global monkeypox outbreak, polio transmission in the U.S., and Ebola in Uganda.