Acetaminophen is widely available over the counter in the United States, increasing the risk of overdose (both acute and chronic). Several factors contribute to the complexity of managing this tricky condition in the emergency department, but until recently, there has been no true standardized approach. Guidance issued in 2023 aims to establish a helpful framework for managing acetaminophen overdose. 

EMRA*Cast host Kyle Duke, MD, breaks it down with EMRA Toxicology Committee Chair Mason Jackson, MD.