Dr RR Baliga's "Got Knowledge Doc" Podkast

Aerobic Activity as Precision Cancer Prevention 🏃‍♀️🎯🧬


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🏃‍♀️ Exercise is not lifestyle advice—it's cancer biology.

A landmark analysis of 443,768 adults from the UK Biobank and NHANES shows that regular aerobic physical activity (≈117–500 min/week) is associated with:

• 21% lower risk of inflammation-related cancers

• 34% lower all-cancer mortality

Mechanistically, exercise:

🔬 Reduces chronic low-grade inflammation

🧬 Reverses immunosenescence (↓ Mki67⁺ immune cells)

🛡️ Expands functional innate and adaptive immunity

Strikingly, the mortality benefit rivals—or exceeds—that of many modern anticancer therapies.

📖 Jin et al., Cell Reports Medicine, 2025

In the era of sedentary epidemics, movement may be our most scalable precision therapy.

#CancerPrevention #PhysicalActivity #Immunosenescence #Inflammaging #ExerciseIsMedicine #Aging #Oncology #PublicHealth

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Dr RR Baliga's "Got Knowledge Doc" PodkastBy Dr RR Baliga, MD, MBA

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