Find out more and make a booking at The Skinesis Clinic here: https://www.sarahchapman.com/

Follow Sarah Chapman London on Instagram here: https://www.instagram.com/sarahchapmanlondon/?hl=en

Listen to the episode to get the full low-down on how Sarah ages well.

Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment.

Find out more by heading to https://drsophieshotter.com/

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This podcast was produced by https://thepodcastpeople.co/

Co-host: https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment.

Some notes and studies etc:

Metformin is increasingly thought to protect against cancer, heart disease, and potentially even Alzheimer’s. Read more: https://pubmed.ncbi.nlm.nih.gov/28802803-metformin-reduces-all-cause-mortality-and-diseases-of-ageing-independent-of-its-effect-on-diabetes-control-a-systematic-review-and-meta-analysis/

Scientists have also shown that Metformin encourages the growth of certain good gut bacteria, which leads to increased production of short-chain fatty acids. Read more: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681099/

A recent longitudinal study shows we still need more research and data. Read more: https://peterattiamd.com/a-recent-metformin-study-casts-doubts-on-longevity-indications/

Dr Sophie mentioned the Targeting Aging with Metformin or TAME study.

Some studies have also shown that metformin can inhibit muscle growth. Read more: https://www.lifespan.io/news/metformin-and-resistance-training-downside-and-upside/#:~:text=Metformin%20restricts%20muscle%20building%20but%20makes%20gene%20expression%20more%20youthful.&text=A%20new%20study%20published%20in,it%20promotes%20youthful%20gene%20expression.

A 2025 American Society of Clinical Oncology Annual Meeting looked at a study of ivermectin in combination with immunotherapy for patients with breast cancer and showed no significant benefit. Read: https://www.oncologynewscentral.com/asco-conference-coverage

Dr Sophie mentioned Primeadine® Original Spermidine.

MORE STUDIES:

https://www.uea.ac.uk/about/news/article/anti-aging-drug-rapamycin-extends-lifespan-as-effectively-as-eating-less

https://www.sciencedirect.com/science/article/pii/S0531556523000876

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

This podcast was produced by https://thepodcastpeople.co/

Co-host: https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Find out more about Dr Kaitlyn here: https://profiles.ucl.ac.uk/88177-kaitlyn-regehr

Follow Dr Kaitlyn on socials – she does occasionally post! – via https://www.instagram.com/kaitlynregehr/?hl=en-gb

Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment.

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

This podcast was produced by https://thepodcastpeople.co/

Co-host: https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Find out more about Prof Ben here: https://www.benbikman.com/

Follow Prof Ben here: https://www.instagram.com/benbikmanphd/?hl=en

Find out more about Insulin IQ here: https://insuliniq.com/

Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment.

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

This podcast was produced by https://thepodcastpeople.co/

Co-host: https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

NOTES:

A study at UCL found that Viagra might help to lower the risk of Alzheimer’s disease.

Bryan Johnson quoted nearly 10 individual studies that talk about Viagra’s effects on longevity. Read more here: https://www.science.org/content/article/viagra-and-other-unlikely-candidates-lead-hunt-new-longevity-drugs

Here’s the Dr Nathan Bryan episode: https://podcasts.apple.com/gb/podcast/loss-of-nitric-oxide-is-directly-linked-to-almost/id1713189123?i=1000664439672

Here’s the Dr Tracy Gapin episode: https://podcasts.apple.com/gb/podcast/from-sex-drive-to-fertility-this-is-a-mens-health/id1713189123?i=1000666738097

Cordyceps research has found it to increase testosterone, while a review concluded that it could enhance libido and sexual performance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791983/

Other references

www.nhs.uk/medicines/sildenafil-viagra/

www.medicines.org.uk/emc/product/7124/pil#gref

www.medicines.org.uk/emc/product/7430/pil#gref

In 2014, a meta analysis of many studies showed cardioprotective effects of PDE5 inhibitors.

In 2018, Cialis showed improved cardiovascular dysfunction and overactive bladder in rats, and in 2019, it was shown to reverse signs of heart failure in sheep.

In 2021, a study out of Karolinska Institute in Sweden showed that PDE5 inhibitors may extend life in men with coronary artery disease.

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

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Co-host and producer https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast

Find out more and get Dr Stacy’s FREE newsletter and articles at: https://www.drstacysims.com/

Get 15% off Dr Stacy’s online courses at https://www.drstacysims.com/product_guide using the code DRSTACYSIMS15OFF

Dr Stacy’s socials:

https://www.facebook.com/drstacysims

https://www.instagram.com/drstacysims

https://www.youtube.com/channel/UCPD55VPa1ZWx1a_nzWC2VJA

https://www.linkedin.com/in/stacy-t-sims-phd/

The below were all mentioned by Dr Stacy:

https://drgabriellelyon.com/

https://www.vaginacoach.com/ and https://www.buffmuffapp.com/

This was the other app mentioned https://www.junofem.com/femfit

Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment.

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

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This podcast was produced by https://thepodcastpeople.co/

Co-host: https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Sophie mentions a few brands – listen in to the episode to find out more (also now adding https://myotahealth.com/ to the mix – a newer prebiotic brand).

The at-home health test eps is here: https://podcasts.apple.com/ie/podcast/a-review-of-at-home-health-test-kits/id1713189123?i=1000674816637

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

Co-host and producer https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast

Head to https://www.beamminerals.com/ to find out more

Buy Beam Minerals in the UK via https://longevity-essentials.com/

Caroline mentioned OligoScan - a non-invasive method used to assess mineral deficiencies, antioxidant levels, and heavy metal accumulation in the body - using spectrophotometry. It involves a device to measure the light absorbed by tissues in the palm, providing insights into intracellular levels of these substances.

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

Co-host and producer https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

Co-host and producer https://fionamattesini.co.uk/

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast

Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment.

Find out more by heading to https://drsophieshotter.com/

Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en

…and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en

This podcast was produced by https://thepodcastpeople.co/

Co-host: https://fionamattesini.co.uk/

SOURCES and articles

https://madesafe.org/blogs/viewpoint/toxic-chemicals-in-air-fresheners

https://www.independent.co.uk/extras/indybest/house-garden/kitchen-accessories/best-natural-cleaning-products-brands-home-that-work-cheap-disinfect-effective-uk-a9624281.html

https://www.forbes.com/sites/brucelee/2018/03/04/cleaning-your-house-may-be-as-bad-as-smoking-20-cigarettes-a-day/

https://www.forbes.com/sites/amywestervelt/2012/09/10/five-things-you-should-know-before-you-clean-your-house/

https://www.womenshealthmag.com/uk/beauty/skin/a706460/best-natural-deodorants/

https://www.independent.co.uk/extras/indybest/fashion-beauty/beauty/best-natural-deodorant-uk-b1804046.html

https://goop.com/beauty/skin/mineral-sunscreen-guide/?srsltid=AfmBOorUrh4myqMZLa9g3s0W8cmdm6Fc0OpuiBloJ7z8kTNV9r_KbJHn

https://www.safecosmetics.org/chemicals/formaldehyde/

https://goop.com/beauty/personal-care/6-of-the-most-common-endocrine-disruptors-and-how-to-avoid-them/

https://goop.com/wellness/detox/how-to-avoid-common-toxic-chemicals/?srsltid=AfmBOor0qXmtJxvkcJZ80uKaJ7YKrQwzURSjLgu9v5cLff-irnsq7s-d

https://www.vogue.co.uk/article/indie-perfumes#:~:text=in%20this%20article:-,Unifrom,Horace

STUDIES:

https://pubmed.ncbi.nlm.nih.gov/21313993/

https://www.ewg.org/guides/substances/22127-QUATERNARYAMMONIUMCOMPOUNDSBENZYLC818ALKYLDIMETHYLCHLORIDES/

https://www.sciencedirect.com/science/article/pii/S0045653523018374#sec3

https://www.ewg.org/news-insights/news-release/2023/09/cleaning-products-emit-hundreds-hazardous-chemicals-new-study

https://oem.bmj.com/content/74/1/39

https://www.thoracic.org/about/newsroom/press-releases/resources/women-cleaners-lung-function.pdf

https://www.sciencedirect.com/science/article/pii/S0160412023000120?via%3Dihub

https://health.ec.europa.eu/publications/sccs-opinion-ethylhexyl-methoxycinnamate-ehmc-cas-no-5466-77-383834-59-7-ec-no-226-775-7629-661-9_en

https://academic.oup.com/ieam/article-abstract/17/5/940/7727851?redirectedFrom=fulltext&login=false

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648445/#R16

https://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm

https://www.sciencedirect.com/science/article/pii/S0160412020320213#s0130

The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.