Over the past two decades, the use of opioids to manage chronic pain has increased substantially. Within this same period, unintentional death related to prescription opioids has been identified as a public health crisis, owing in part to such factors as insufficient professional training and medication overprescription, misuse, and diversion. AJN’s editor-in-chief Shawn Kennedy speaks with Risa Denenberg and Carol P. Curtiss about their article, which offers an overview of current best practices for prescribing opioids for chronic pain.