Howie and Harlan are joined by cardiologist Ali Rahimi, the founder of ALYKA Health, which uses a personalized mobile app to help patients manage their heart health between doctor's visits. Harlan discusses new developments in GLP-1 obesity drugs, including untested microdose treatments; Howie reviews a landmark study investigating whether broad prostate cancer screening saves lives.

Show notes:

GLP-1 Drugs

"Microdosing aims to extend the lifespan of the GLP-1 compounding market"

NIH: Regulatory Framework for Compounded Preparations

Health & Veritas Episode 140: Lee Schwamm: Smarter Healthcare Systems With AI

"FDA takes on GLP-1 compounding boom with warnings about misleading marketing"

"Should You Microdose GLP-1 Drugs?"

"How microdosing GLP-1 drugs became a longevity 'craze'"

"Bidding war between Pfizer, Novo Nordisk for obesity startup Metsera escalates"

"Trump Negotiating Deal With Ozempic Maker to Sell Some Weight-Loss Drugs for $149""Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment"

"How Ozempic's Maker Lost Its Shine After Creating a Wonder Drug"

Ali Rahimi

ALYKA Health

Harlan Krumholz and Ali Rahimi, "Financial Barriers to Health Care and Outcomes After Acute Myocardial Infarction"

"Why High Blood Pressure Matters to Your Health"

Building a Better Delivery System: A New Engineering/Health Care Partnership

NIH: The 21st Century Cures Act

New Evidence on Prostate Cancer Screening and Breast Cancer Treatment

National Cancer Institute: Cancer Stat Facts: Prostate Cancer"

U.S. Preventive Services Task Force: Prostate Cancer: Screening"

"The pros and cons of PSA tests for prostate cancer for midlife and older men"

"Share on European Study of Prostate Cancer Screening — 23-Year Follow-up"

"Early Detection of Prostate Cancer — Time to Fish or Cut Bait"

"Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer"

"Omission of Chest-Wall Irradiation after Mastectomy for Breast Cancer"

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