In a special episode recorded at Connecticut’s largest entrepreneurship event, Howie and guest host Megan Ranney, the dean of the Yale School of Public Health, welcome four Yale innovators: entrepreneur and YSPH lecturer Kaakpema “KP” Yelpaala; Basmah Safdar, director of Women’s Health Research at Yale; Kayla Wooley, a YSPH graduate and the founder of two nursing home staffing companies; and Yale College student Laurie Jimenez, founder of FulcrumCare, a value-based dental provider for Medicaid and Medicare patients. 

Links:

The Yale Innovation Summit

Yale Innovation Summit 2025

Yale Ventures

Kaakpema “KP” Yelpaala

“Public health innovator Kaakpema Yelpaala appointed senior fellow and lecturer at YSPH”

InnovateHealth Yale

Cityblock

Girl Effect

Basmah Safdar

“Basmah Safdar, MD, FACEP, Appointed Director, Women’s Health Research at Yale (WHRY)”

Women's Health Research at Yale

“Heart attack symptoms often misinterpreted in younger women”

“Sex Differences in COVID-19 Immune Responses Affect Patient Outcomes”

“The Truth About ‘Man Flu’”

“Drug Agency Recommends Lower Doses of Sleep Aids for Women”

Kayla Wooley

StaffOnTap

“Nursing home staff shortages prompted YSPH alumna to form two companies”

“Nursing Home Staffing Shortages and Other Problems Persist, U.S. Report Says”

“State Of The Sector: Nursing Home Labor Staffing Shortages Persist Despite Unprecedented Efforts To Attract More Staff”

Hinge Health

Laurie Jimenez

FulcrumCare

“Many Medicare Beneficiaries with Dental Insurance Face Financial Barriers to Care”

“Variation in Use of Dental Services by Children and Adults Enrolled in Medicaid or CHIP”

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Rebekah Gee, founder and CEO of Nest Health, which provides in-home care to kids on Medicaid and their families. Harlan reports on the first personalized CRISPR gene therapy for a rare genetic disease; Howie untangles the FDA’s restrictions on the COVID-19 booster and what it will mean for your ability to get a shot this fall. 

Links:

A Breakthrough CRISPR Treatment

“Baby Is Healed With World’s First Personalized Gene-Editing Treatment”

“Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease”

“Progress in the Development of N-of-1 Therapy”

“Personalized Gene Editing to Treat an Inborn Error of Metabolism”

Nest Health

Health & Veritas Episode 40: Rebekah Gee: Can We Bring Family Healthcare to the Home?

Nest Health

“Nest Health picks up $4M in seed extension funding to build out at-home primary care for families”

“How Nest Health Is Redefining Primary Care for Families”

Rebekah Gee on LinkedIn on Nest Health

“What ‘patient-centered‘ should mean: confessions of an extremist”

“Prevalence and Variation of Developmental Screening and Surveillance in Early Childhood”

“Postpartum health is in crisis”

“The Impact of the Pandemic on Well-Child Visits for Children Enrolled in Medicaid and CHIP”

“Families often have chief medical officers—and they're almost always women”

“Case Study: Louisiana's Poor Rankings Make Improving Birth Outcomes a State Imperative”

“In 6-to-3 Ruling, Supreme Court Ends Nearly 50 Years of Abortion Rights”

Rebekah Gee on LinkedIn on Medicaid cuts

“5 Key Facts About Medicaid Work Requirements”

“Health Provisions in the 2025 Federal Budget Reconciliation Bill”

A New COVID Booster Policy

“An Evidence-Based Approach to Covid-19 Vaccination”

“FDA will limit Covid vaccines to people over 65 or at high risk of serious illness, leaders say”

“FDA tightens requirements for COVID vaccine, adding trials for healthy adults”

Learn more about the MBA for Executives program at Yale SOM.

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Howie and Harlan are joined by James Dodington, a Yale pediatric emergency medicine physician and an expert in community-based violence prevention. Harlan reports on the remarkable financial results and sometimes questionable science of Hims & Hers Health; Howie discusses UnitedHealthcare’s faltering stock price in the face of anger over aggressive care denial and a lawsuit from shareholders.

Links:

Oscar Health and Hims & Hers

“Oscar Health Profits Eclipse $275 Million As Obamacare Enrollment Soars”

“Hims & Hers Health Revenue Jumps, But Outlook Disappoints”

“Hims & Hers' Q1 revenue doubles to $586M, boosted by growth in weight loss business”

“Novo Nordisk to sell Wegovy through telehealth firms to cash-paying US customers”

“They Wanted a Quick Fix for Hair Loss. Instead, These Young Men Got Sick.”

“EU drugs regulator confirms suicidal thoughts as side effect of hair loss drug”

“Measures to minimise risk of suicidal thoughts with finasteride and dutasteride medicines”

“FDA alerts health care providers, compounders and consumers of potential risks associated with compounded topical finasteride products”

James Dodington

Health & Veritas Episode 81: Joseph Sakran: Confronting Gun Violence

Health & Veritas Episode 77: Megan Ranney: What’s Next for Public Health?

“Children and teens are more likely to die by guns than anything else”

“U.S. Surgeon General Issues Advisory on the Public Health Crisis of Firearm Violence in the United States”

“New Report Highlights U.S. 2022 Gun-Related Deaths: Firearms Remain Leading Cause of Death for Children and Teens, and Disproportionately Affect People of Color”

James Dodington: “Rural Versus Urban Hospitalizations for Firearm Injuries in Children and Adolescents”

“Disparities in Pediatric Mental and Behavioral Health Conditions”

“Special Report: Dean Megan Ranney Brings a Public Health Approach to the Country’s Gun Violence Epidemic”

“Gun Violence Is a Public Health Crisis—But Hospital-based Intervention Programs Can Help Break the Cycle”

“Implementation of an emerging hospital-based violence intervention program: a multimethod study”

UCSF Wraparound Project: The Public Health Model for Violence Prevention

“Just Listen”

Firearm Injury Prevention at the Yale School of Public Health

“11 Years After Sandy Hook—A New Path Toward Healing and Hope”

Nelba Márquez-Greene’s Shared Humanity Podcast

4-CT:Violence Intervention and Prevention

“Cash Pilot Targets Violence Victims”

“How unrestricted cash aid is transforming violence intervention in Connecticut”

Pepe Vega’s story: “Gun Violence Is a Public Health Crisis—But Hospital-based Intervention Programs Can Help Break the Cycle"

“Yale undergraduate team takes first place in national health policy competition”

UnitedHealthcare

“UnitedHealth CEO Is Out, Sending Shares Plummeting”

“UnitedHealthcare sued by shareholders over reaction to CEO's killing”

UnitedHealth Shareholder Lawsuit

“UnitedHealth's string of setbacks, from exec murder to cyber attack”

“Zepbound Patients Fear Losing Coverage After CVS Deal for Wegovy”

“Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs”

Howie and Harlan are joined by Thomas Gill, a Yale geriatrician whose research tracks the factors that contribute to disability in older adults—and those that support continued independence. And they discuss the contrarian tapped to evaluate vaccines at the FDA, allegations of kickbacks against insurers, and the potential end of a loophole that has allowed states to collect additional Medicaid funding. 

Links:

Vinay Prasad at the FDA

“Vinay Prasad tapped to run FDA center that regulates vaccines, gene therapies”

“Vinay Prasad, in his own words, outlines the philosophy he’ll bring to the FDA”

“Peter Marks, FDA’s top vaccine regulator, forced out”

Howard Forman on LinkedIn on Vinay Prasad's Appointment

Vinay Prasad's Substack

Insurance News

“Justice Department Sues Big Medicare Insurers Alleging Kickbacks”

“Aetna to exit the ACA exchanges in 2026”

“What Aetna quitting the exchanges says about the exchanges”

”CVS to boost access to Novo Nordisk’s weight loss treatment Wegovy for patients on its drug plans”

Thomas Gill

Statista: Share of old age population (65 years and older) in the total U.S. population from 1950 to 2050

Thomas Gill: “A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study”

Thomas Gill: “A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home”

“Prehabilitation for Patients Undergoing Orthopedic Surgery: A Systematic Review and Meta-analysis”

“Allostatic Load: Importance, Markers, and Score Determination in Minority and Disparity Populations”

“Cohort Profile: The Precipitating Events Project (PEP Study)”

“In Memoriam: Yale Expert in Clinical Research Methods, Alvan R. Feinstein”

Medicaid Cuts

“Putting $880 Billion in Potential Federal Medicaid Cuts in Context of State Budgets and Coverage”

“Republicans are running out of ways to cut Medicaid as moderates and hard-liners clash”

“G.O.P. Targets a Medicaid Loophole Used by 49 States to Grab Federal Money”

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Joel Bervell, a recent medical school graduate who uses social media platforms to combat misinformation and explain racial biases in healthcare. Harlan discusses his new Wall Street Journal commentary highlighting the link between viral infections and chronic diseases; Howie reports on powerful new evidence for the effectiveness of the HPV vaccine and warns of the dangers of a vaccine-skeptical presidential administration.

Links:

Viral Infection and Chronic Disease

Harlan Krumholz: “How to Lead a Chronic Disease Revolution”

“A natural experiment on the effect of herpes zoster vaccination on dementia”

“Unexplained post-acute infection syndromes”

Joel Bervell

Joel Bervell

Joel Bervell on TikTok

Joel Bervell on Instagram

“TikTok's 'Medical Mythbuster' Helps Save Lives By Tackling Racial & Gender Disparities In Healthcare”

“How the pulse oximeter became infamous on TikTok”

“Racial Bias in Pulse Oximetry Measurement”

Joel Bervell’s TikTok on the pulse oximeter

Joel Bervell: “The eGFR Equation”

“Race Correction and the X-Ray Machine: The Controversy over Increased Radiation Doses for Black Americans in 1968”

Joel Bervell: “For over 50 years, X-ray technicians were taught to administer higher radiation doses to Black patients”

Joel Bervell’s Instagram reel on bias in the measurement of lung capacity

Made to Stick: Why Some Ideas Survive and Others Die

Joel Bervell on LinkedIn

Joel Bervell on YouTube: The Doctor Is In

Kickstarter: The Doctor Is In

“Medical mythbuster Joel Bervell, MD, on how to teach kids about medicine and address misinformation”

Cleveland Clinic: Amyloidosis

Joel Bervel’s Instagram reel on the GFR equation

“Abandoning a Race-biased Tool for Kidney Diagnosis”

“OPTN Board approves elimination of race-based calculation for transplant candidate listing”

“America’s News Influencers”

“85th Annual Peabody Awards Announce Nominees for the Arts, Children’s/Youth, Entertainment, and Interactive & Immersive Categories

Vaccines and the Federal Healthcare Agencies

Health & Veritas Episode 165: “Aging in Bursts and Other News”

“U.S. government researchers present ‘phenomenal’ new data on HPV vaccines”

“Invasive cervical cancer incidence following bivalent human papillomavirus vaccination: a population-based observational study of age at immunization, dose, and deprivation”

“Kennedy played key role in Gardasil vaccine case against Merck”

“RFK Jr. suggests some vaccines are risky or ineffective, downplays measles threat”

“FDA chief says they're looking at whether to approve COVID shots for next winter”

“How Marty Makary’s FDA is embracing a more skeptical view of vaccines”

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.

Howie reflects on his decades-long experience with paroxysmal atrial fibrillation and the procedure that has changed his life. Howie and Harlan report on healthcare issues in the news, including the measles outbreak and a vision for a team of personal healthcare AI agents. And student research assistants Inès Gilles and Sophia Stumpf visit for a farewell interview.

Links:

Eric Topol: Ground Truths

Eric Topol: Super Agers

Harlan Krumholz: The Expert Guide to Beating Heart Disease: What You Absolutely Must Know

Paroxysmal Atrial Fibrillation

“What to know about paroxysmal atrial fibrillation”

Joseph Akar, MD, PhD

Mayo Clinic: Atrial fibrillation ablation

“The True Cost of a Cardiac Ablation in the U.S.”

AI Agents

“The Four AI Agents of Your Health”

“This A.I. Forecast Predicts Storms Ahead”

Measles

CDC: Measles Cases and Outbreaks

“Measles Surge in Southwest Is Now the Largest Single Outbreak Since 2000”

Mayo Clinic: History of Measles

Food as Medicine

“Cooking with the curriculum: a pilot culinary medicine program at the Larner College of Medicine”

“Bringing Culinary Medicine to Yale’s New Teaching Kitchen”

Bird Flu

CDC: H5 Bird Flu: Current Situation

“Vietnam reports H5N1 avian flu case with encephalitis”

Exercise and Brain Waste

“Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans”

“The brain makes a lot of waste. Now scientists think they know where it goes”

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.

Deepak D'Souza, the Vikram Sodhi ’92 Professor of Psychiatry at Yale, explains risks from highly potent cannabinoids and research on treating mental health conditions with psychedelics. Harlan reports on efforts to understand the neuroscience around artificial sweeteners. Howie highlights insights from a physician pay survey.

Links:

Artificial Sweeteners

"WHO advises not to use non-sugar sweeteners for weight control in newly released guideline"

"Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights"

"Artificial sweetener found in diet drinks linked to brain changes that increase appetite, study finds"

"Why One Cardiologist Has Drunk His Last Diet Soda"

Cannabis

"Marijuana: Rising THC Concentrations in Cannabis Can Pose Health Risks"

"Cannabis and Driving"

"CBD vs. THC: What's the Difference?"

"The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis"

"Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis"

"Cannabidiol (CBD): What we know and what we don't"

"FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy"

"Jacques Joseph Moreau (1804–1884)"

"Cannabis and psychosis: revisiting a nineteenth century study of 'Indian Hemp and Insanity' in Colonial British India"

"Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction"

"The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study"

"Association of Cannabis Use During Adolescence With Neurodevelopment"

"The endocannabinoid system: Essential and mysterious"

Dronabinol: MedlinePlus

Dr. D’Souza

"D’Souza named Vikram Sodhi Professor of Psychiatry"

"CT Yale researcher gets $3 million chair to study DMT use for depression, PTSD"

Physician Pay

"Comparing Your Pay Against Your Peers’: Medscape Physician Compensation Report 2025"

"Physician compensation rose 3.6% in 2024, but not all specialties got a raise"

"Biggest Match Day ever: Here’s what the 2025 numbers reveal"

"Ryan Schwarz: Thinking Differently about the Primary Care Crisis"

Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan welcome Evan Sussman, the CEO of Granata Bio, which aims to bring IVF and fertility drugs that have been proven in other markets to the United States. Harlan reports on Elon Musk’s Neuralink, which will test a technology to restore rudimentary sight to the blind; Howie tries to reconcile conflicting reports about the viability of the Medicare trust fund. 

Links:

Neuralink

“Elon Musk announces Neuralink’s first human implant of Blindsight coming this year”

“Musk's Neuralink gets FDA's breakthrough device tag for 'Blindsight' implant”

“Elon Musk's Neuralink receives Canadian approval for brain chip trial”

Forbes: Elon Musk

Granata Bio

Granata Bio

 “Fertility treatment costs are out of reach for many Americans, even with insurance”

“Acceptable cost for the patient and society”

“Meeting the demand for fertility services: the present and future of reproductive endocrinology and infertility in the United States”

RESOLVE: The National Infertility Association: Insurance Coverage by State

“Politicians say health plans should cover IVF. Currently only 1 in 4 employers do”

“Catching Up with Alumni: The Founders of Granata Bio”

“IBSA Group and Granata Bio announces first patient screened in pivotal PROGRESS clinical trial of Progesterone-IBSA”

“Women's Health Innovator Granata Bio Raises $14M Series A led by GV to Accelerate Fertility Biopharma Pipeline”

“Women's Health Innovator Granata Bio Raises $15M Series A+ to Further Develop and Expand Reproductive Health Pipeline”

“Trump signs executive order seeking to expand IVF access”

The Medicare Trust Fund

“The Long-Term Budget Outlook: 2025 to 2055”

“Medicare gets a big (unofficial) surprise: a 17-year extension on when it’ll run dry”

“CMS Finalizes 2026 Payment Policy Updates for Medicare Advantage and Part D Programs” 

“Health Insurer Stocks Soar on Medicare Rate Boost”

“Insurer-Level Estimates of Revenue From Differential Coding in Medicare Advantage”

Medicare.gov: “How is Medicare funded?”

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Alexi Nazem, a Yale-trained internist who co-founded the healthcare staffing company Nomad Health and now leads healthcare investments at AlleyCorp. Harlan reports on new research from the American College of Cardiology meeting; Howie examines the consequences of vast staffing cuts in the federal healthcare infrastructure. 

Links:

Research from the American College of Cardiology Meeting

“Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial”

“Early Intra-Aortic Balloon Support for Heart Failure-Related Cardiogenic Shock: A Randomized Clinical Trial”

“Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism”

Alexi Nazem

The Human Genome Project

Institute for Healthcare Improvement

“100,000 Lives Campaign: Ten Years Later”

“Continuous Improvement as an Ideal in Health Care”

“The Science of Improvement”

Health & Veritas Episode 145: Max Laurans: An Entrepreneurial Life in Medicine

Nomad Health

Yale School of Management case study: “Nomad Health: The disruption of physician staffing services"

“Staffing Marketplace Nomad Health Raises $105 Million As It Expands Beyond Travel Nurses”

“America Is Running Out of Nurses”

“Staffing Marketplace Nomad Health Lays Off 17% Of Workforce”

“Why AI deals in healthcare have grown faster than other areas of tech — and what VCs are paying close attention to”

Turmoil at Federal Health Agencies

“Mass Layoffs Hit Health Agencies That Track Disease and Regulate Food”

“The top FDA vaccine official is forced out, cites RFK Jr.'s 'misinformation and lies'“

“NIH cuts halt 24-year program to prevent HIV/AIDS in adolescents and young adults”

“Princeton's US grants frozen, follows Trump actions against other schools”

“Trump Administration Abruptly Cuts Billions From State Health Services”

“Texas measles outbreak grows to 90 cases, worst level in 30 years”

“As Trump pursues his policies, Democratic states block his path”

“Proposed foreign aid cuts could lead to millions of HIV deaths, study estimates”

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Ryan Schwarz, a Yale-trained MD-MBA who oversees accountable care for the Massachusetts Medicaid program, to discuss new models for addressing the severe shortage of primary care doctors in the U.S. Harlan looks at the fallout from the bankruptcy of 23andMe; Howie reports on Match Day at Yale and medical schools around the country.

Links:

New Leadership

“Senate Confirms Bhattacharya and Makary to H.H.S. Posts”

“Keir Starmer Wants to Abolish N.H.S. England: What to Know About His Plan”

23andMe

“23andMe Files for Bankruptcy Amid Concerns About Security of Customers’ Genetic Data”

“Data Breach at 23andMe Affects 6.9 Million Profiles, Company Says”

“23andMe user data targeting Ashkenazi Jews leaked online”

“Attorney General Bonta Urgently Issues Consumer Alert for 23andMe Customers”

U.S. Senate Bill S.5433: Genomic Data Protection Act

Ryan Schwarz

“The Health of US Primary Care: 2025 Scorecard Report—The Cost of Neglect”

“Finger on the Pulse: The State of Primary Care in the U.S. and Nine Other Countries”

Massachusetts Health Insurance Survey

“Revisiting the Time Needed to Provide Adult Primary Care”

“How Algorithms Could Improve Primary Care”

Ryan Schwarz: “Primary Care Sub-capitation in Medicaid: Improving Care Delivery in the Safety Net”

MassHealth Primary Care Sub-Capitation: Program Overview

“The first community health centers: a model of enduring value”

“Community Health Centers’ Progress and Challenges in Meeting Patients’ Essential Primary Care Needs”

Match Day

“Biggest Match Day ever: Here’s what the 2025 numbers reveal”

“Yale School of Medicine Celebrates Match Day”

Video: Match Day 2025: Winners & Losers Edition

Learn more about the MBA for Executives program at Yale SOM.

Email Howie and Harlan comments or questions.