This last Alloutcoach podcast episode of 2024 is the most

0:00 Episode Intro Music

0:07 Highlight #1 – Three Times I was fired / laid off

2:45 Highlight #2 – Noah Lyles’ loss of gold medal at his

3:35 Highilght #3 – Recipe for Consistency of High

6:13 Episode Introduction – Summary of the 2024 Medical Affairs

7:52 Detailed Episode Outline

8:49 Current State of Competition in Medical Affairs and

External and Internal Pressures of Competition and their

Major Layoffs due to changing workflows and inaccurate forecasting.

Need of Medical Affairs to discover new power in medical decisions

2024 Medical Affairs Innovation Spectrum – collaborating with

12:20 Our Perceptions of Competition vs Reality in Sports vs

Life Compass with only two directions – Progress and Success

14:03 Why I have always gone to work as if it were a sport I

15:07 Case Study – Leading Medical to grow a Pharma Startup

18:07 Personal Reflection and Analysis – Why I was fired / reorganized

23:14 Paris 2024 Olympics Lesson #1 – Respect Your

Noah Lyles’ claims of superiority in an event he dominated

Recent personal observation and outcome of a child celebrating

Gary Hall Jr, 5-time Olympic Gold Medalist – won his first Olympic

27:58 Paris 2024 Olympics Lesson #2 – It is the Final Lean

Noah Lyles’ closest margin of gold medal victory in the 100-meter

Dominant Italian national teams in volleyball and water polo

29:51 Paris 2024 Olympics Lesson #3 - Recipe of Consistency

Carl Lewis’ remarkable consistency of winning 4 consecutive

Greek Long Jumper Miltiadis Tentoglou and Women’s South

Personal application of mastering cooking pasta

33:20 Paris 2024 Olympics Lesson #4 – Never Bypass the

US Men’s 4 x 100 Sprint Relay Team’s Inefficient Baton Pass

Marquis Dendy, US veteran, best current long jumper’s

Damian Warner, Canadian decathlete Olympic gold medalist’s

35:13 Paris 2024 Olympics Lesson #5 – Adapt to New Rules and

The judge or new competition format led to an unpredictable

Celebrate Competition in Medical Affairs to stay competitive

Clinical research is undergoing a revolution in light of new demands for speed and opportunities from a technological standpoint. These trends have given rise to a debate about the quality and clinical meaning of traditional methods of investigations versus modern types of clinical studies to collect real world evidence.

0:09 Episode Highlight

3:09 Innovation Olympics Introduction

4:44 Debate Rules & Introduction

6:30 RCTs are the Gold Standard for Research and Learning - For the Motion - Sana Syed

24:48 Agency for Healthcare Research and Quality (AHRQ) - ~17 yrs to translate data into real world

49:31 Final Comments - Against the Motion, Rashad Massoud

53:14 Live Voting Results

In this special episode you will have an opportunity to learn about the key factors to not only living longer but better and higher quality lives from a global expert and pioneer researcher in longevity medicine, Dr. David Barzilai. David provided an update of the landscape in this field as a keynote speaker at the 3rd annual Medical Affairs Innovation Olympics held in October. David is CEO and founder of Healthspan Coaching, LLC., and agingdoc.com, providing longevity medicine and lifestyle consulting. Dr. Barzilai is a Diplomate at the American Board of Lifestyle. He is board-certified in dermatology, with a PhD focused on evidence-based medicine, and also holds an MBA.

In his keynote presentation, Dr. Barzilai critically addresses the gaps in treating only one disease at a time and provides alternative methods that target root, underlying causes of disease that can prevent multiple chronic diseases and lengthen the human Healthspan. David challenges the healthcare community and Medical Affairs function in pharma and biotech with a call to action to prioritize efforts to improve healthspan and transform medicine.

0:00 Timeline

0:09 Episode Highlight + Call to Action

1:30 Host Introduction of the Episode

4:17 Keynote Speaker's Presentation Overview

5:04 Dramatic Increase in Global Aging Population

6:10 Gray Tsunami Economic Impact - Rising Health Expenditures

20:10 Questions: Roles of 1) Neuralink + 2) Telehealth on Longevity

21:07 Role of Telehealth - know your target audience/sub-specialization is a key factor

22:24 Neuralink comments - exponential increase of dementia

Bob Beamon is a multi-talented champion that has followed the path of his own inspiration to generate excitement and purpose throughout life. In order to succeed and leave a legacy on others, he had to make the decisive steps to make the right jumps in sports to break longest-standing world and Olympic records as well as in life to follow his many dreams and succeed. At the 3rd annual Medical Affairs Innovation Olympics, I sat down with Bob Beamon to learn how his sports career and multiple inspirations (basketball) influenced the decisions he has made in his personal life and success in continuing to reinvent himself as a champion in music. We explored explore what makes the long jump one of the most classic and difficult events in track and field and possibly sports, the individual components and mechanics of the jump, how his talent, circumstances, and training led to his success. In addition, he discusses his personal theories on competition, approaches to edging out competitors in sports, and transition into how he defines competition in life and what impact his environment, character, and personal inspiration have played on the kinds of jumps he has had to make in his personal life to follow multiple different and challenging paths yet succeed.

0:00 Episode Intro

4:20 First Jump in Bob's Life that shaped his career afterwards.

Bob's tough childhood and background

Bob Beamon is a multi-talented Olympic champion that has followed the "beat" of his own inspiration to make the right jumps in sports and throughout his life. In order to succeed and leave a legacy on others, he had to make the decisive steps in sports to break the longest-standing world and Olympic records as well as in life to follow and achieve his many dreams. On this episode of the @Alloutcoach podcast where sportsmanship meets the scientific method, I sat down with Bob Beamon to learn how his sports career and multiple inspirations (basketball) influenced the decisions he has made in his personal life and success in continuing to reinvent himself as a champion in music. In this conversation leading to his keynote presentation at the 3rd annual Medical Affairs Innovation Olympics event (see follow up episode - stay tuned), Bob presents a very personal, detailed account of how his particular talent, challenging circumstances, approaches to training as well as facing adversity led to his success. In addition, he demonstrates the role his life inspiration and sports competitor's character played on reinventing himself throughout his career across his life transitions including the latest one in retirement as a musician.

1:04 Episode Intro

3:08 What inspired Bob to become a sports athlete

Growing up in South Jamaica, New York, rough childhood. Bob's involvement in the Police Athletic League thanks to which he started to compete in track and field.

6:04 Bob did not stop competing because he lost consistently

8:02 Transition from sprint to long jump

8:46 First long jump competition - 19 feet at 10 years of age

10:32 Bob's family background and early loss of his mother

12:38 Junior Olympics in New York - Turning Point at age 14

15:09 What makes the long jump special and difficult

Bob's background in the triple jump. He had jumped 25 feet 6 inches in high school. The event requires consistency in training, coaching, and inner drive.

20:48 Bob's coach Larry Ellis did not force Bob to change his peculiar form of jumping

Bob's technique - jump over a hurdle during training to maintain a height. He perfected an "unorthodox" form of jumping.

24:43 Reliving Bob's 1968 World Record Jump in Mexico City

26:38 Advantage of working out with best sprinters in the world

Bob's adjustments to the long jump the day before the final only qualifying on the last attempt.

30:12 Bob's Attitude & Mindset on the morning of his World Record

32:16 Specific Goal of Winning Olympic Gold vs. World Record

34:26 The emotions of breaking a world record

38:46 Nothing compares to the Intensity of the Olympics

41:02 How Bob reinvented himself as a musician at age 77

43:48 Welcoming the new challenge of becoming a drummer

Bob played with a Grammy-award winning band, opened the Track and Field competition at the Paris 2024 Olympics with a musical performance

This is a special Episode Edition on the @Alloutcoach Podcast. Tune into this memorable highlight from the 2023 Medical Affairs Innovation Olympics event Opening Ceremony full of real-world practical case studies, striking new statistics, and critical commentary - an expert panel discussion about the details necessary to make both short-term and long-term marks on improving healthcare quality from both the perspective of a globally recognized healthcare quality expert physician and public health speaker, Dr. Rashad Massoud (Visiting Faculty T.H. Chan School of Public Health), and of an innovative pharma industry executive recognized for his leadership and dedication to patient advocacy groups, holding senior leadership roles in Commercial, Marketing, Market Access and most recently in Medical Affairs, Rob Adamoski (Vice President, Corcept Therapeutics).

0:00 Intro Music

0:22 Episode Highlight

Cushing Syndrome Case Study - Perception Gap on Treatment Quality between Patients vs their Healthcare Providers.

4:11 Panel Discussion Outline

4:38 Global Healthcare Quality Improvement Case Study

16:46 Role Medical Affairs in Pharma can Play on Health Quality

17:56 Connection to Disease - Stimulating Purpose in Medical Affairs

19:29 Value of Recent and Relevant Clinical Experience in Medical Affairs

20:21 Aiming for Diversity of Experience across entire Care Continuum

22:07 Finding the Right Balance on Your Medical Affairs Team

22:58 Case Study: Personalized Medical Liaison led Executive Staff training

25:01 Critical Gaps in Training in Medical Affairs Team - benchmarking data

Larger Organizations offer more training opportunities vs mid-sized and smaller pharma or biotech companies in Medical Affairs. Only 42% of Medical Affairs organizations provide any training and only 23% of small pharma companies (Medical Affairs Professional Society)

27:01 Why Most of Us in Medical Affairs believe Metrics are not Meaningful

30:12 2023 Medical Affairs Metrics Global Benchmarking Gap in Analysis70% of Medical Affairs companies do not systematically analyze how their activities lead to outcomes

30:41 The Motive to Measure Performance in Medical Affairs with KPIs

31:24 Medical Productivity Index (MPI) Model to Increase Performance

32:25 Integrating Health Systems Approaches to Metrics in PharmaAll-Mobile Hypertension Clinics that improved quality and bridges health equity gaps - India Case Study

42:38 Medical Affairs Improving Healthcare Decisions - Patient Advocacy

47:00 How Healthcare Cost relates to Quality - latest trends

49:44 How can we make Healthcare Jobs Desirable again?

This latest episode is centered around discussing how mentorship directly impacts our bottom line in business and personal career based on real-world examples and decades of research. I speak about this topic with a returning guest on the show, co-author of a new book and practical step by step guide just published called "Financial Times Guide to Mentoring", Dr. Ruth Gotian, Chief Learning Officer at Weill Cornell Medicine in New York.

Dr. Gotian is a globally recognized mentorship expert by Nature, Wall Street Journal and Columbia University who named her a top 20 mentor worldwide, a mentorship thought leader ranked by Thinkers50 as the #1 emerging management thinker in the world in 2021, award-winning book author of "The Success Factor" previously featured on Alloutcoach, and prolific contributor to Harvard Business Review, Forbes, and Psychology Today having interviewed Nobel Prize winners, astronauts, Olympic champions, leading physicians and scientists of our time, among others.

0:00 Episode Highlight

0:44 Episode and Guest Introduction

3:08 Advantages and disadvantages of formal versus informal mentorship programs

61% of mentorship is informal. Formal mentorship programs can however be a launching pad for those uncomfortable to seek out mentors or mentees

5:23 Why is it crucial to find mentors outside of your direct line of management?

It is important to diversify mentors in case they leave or you decide to leave.

7:14 Shared experiences in mentorship and how to identify informal mentors

Steve Kerr, NBA champion and coach's example of his lesson from a football coach and mentor: Mentorship is more than technical coaching or shared experiences. It is about shared values and the kind of culture you create in a relationship.

9:13 How mentors make impact business bottom line and job satisfaction

Those who have a mentor earn more, are happier at work, and stay longer. 89% of employees with mentors feel their contributions are valued by others.

11:28 Most common barriers and misconceptions in mentorship

15:36 How do you continue to learn informally despite higher titles or roles?

18:29 What proportion of mentorship should be informal vs. formal or experiential?

22:40 Should minorities, women, etc seek mentors with the same background?

24:41 What surprised Dr. Gotian during the writing process of her latest book?

25:45 How Dr. Gotian and her co-author Andy Lopata complement each other?

27:52 How do you tell when mentorship is successful?

29:38 Biggest achievement with "Financial Times Guide to Mentoring"

31:11 How Dr. Gotian is stretching herself and lifting others in her next projects

On the latest episode of Alloutcoach, I spoke to Neel Doshi whose research on human motivation and performance has inspired me over the years.

Watch this video podcast to understand why I consider him one of the brightest minds in organizational change research who has created forward-thinking solutions that can transform your business. Neel Doshi is Co-founder and CEO of Vega Factor and Factor.AI https://www.factor.ai, NY Times and Wall Street Journal best-selling author of "Primed to Perform", multiple award-winning founder of various tech startups, MIT graduate in engineering and Wharton Business School MBA.

0:00 Intro

In this Part 2 of the Alloutcoach podcast episode focused on phage therapy to fight infections and antimicrobial resistance, I spoke to the Chief Physician at the globally leading center of excellence of an alternative, effective treatment approach to antibiotics, Dr. Dea Nizharadze at the Eliava Phage Therapy Center (EPTC) based in Tbilisi, Georgia. She explains the basic principles of phage treatments, its unique qualities, advantages and real-world clinical examples of methods and types of patients and infections this personalized therapy specifically targets.

0:00 Episode Introduction

1:42 Why the Republic of Georgia is a global leader in phage therapy

2:39 How phage therapy works in bacterial infections?Eliava Phage Therapy Center (EPTC) was founded in 1923 by Professor George Eliava who had collaborated with Felix D'Herelle, who had discovered phages, and while most other countries turned to antibiotics only, it is the only institution in the world that has continued to research bacteriophages without a pause of even one day since its inception and therefore collected the greatest research and real-world clinical experience with phages.

5:34 How do phages work to eradicate or stop further growth of bacteria?

Phages are biological "weapons" against bacteria, namely viruses that target specific microbes only, without destroying the "good" bacteria or microbiota. They are naturally occurring substances and have no safety concerns. In some patients with antimicrobial resistance phage therapy enables improvement in sensitivity.

10:42 Synergistic effect of phage combination therapy with antibiotics

11:58 Phage Therapy Doisng and Success Factors

15:14 Length of phage treatmentIn chronic infections phage therapy may divided into 3 stages and last 15-20 days, and varies by nature and severity of disease. Patient treatment includes days off therapy, or holidays, however, bacterial analysis is continued and patient condition is monitored throughout the entire course of treatment. Success of therapy is indicated when bacterial titers and virulence decrease or bacteria are eradicated. Patient's objective and subjective signs and symptoms often vary throughout response to therapy.

How do we ensure educating patients to access the correct, most appropriate therapy for their infections

17:35 Multi-disciplinary personalized team care and telemedicine

19:53 Steps for patients outside of Georgia to access phage therapy via telemedicine?

24:04 Affordability and access to phage treatments

25:23 How to contact Eliava Phage Therapy Center

In this special episode I spoke with an international guest from my native country, Republic of Georgia, and global ambassador of a critical alternative solution against tough chronic infections and antimicrobial resistance on behalf of a global center of excellence in bacteriophage therapy, discovered over 100 years ago. My guest, Davit Sturua, Doctor of Business Administration, Public Health and Medical Tourism expert, is the director of the Eliava Phage Therapy Center, a global leader in real-world, clinical, research, and commercial experience with naturally occurring bacteriophage treatments. He discusses the Georgian center's 100-year old history and evolution, its extensive experience treating patients across 84 countries, explains the current global public health problem, and provides an update along with rationale on the recent growth in clinical studies investigating phage therapy across the globe in this part 1 of 2 episodes on this topic. Watch this episode with English subtitles to learn about how you, your friends, family, healthcare payers and experts, healthcare providers, patients and their loved ones can consider alternative options via telemedicine or in person to treat chronic, tough bacterial infections or prevent antimicrobial resistance. Stay tuned for the next episode (part 2) on this topic with my guest Dr. Dea Nizharadze, Chief Physician at the Eliava Phage Therapy Center, who delves deeper into the typical course of treatment, patient journey, and various scientific attributes of phage treatments.

0:00 Introduction

0:08 Introduction in English

2:19 Special Guest Mr. Davit Sturua, Director of Eliava Phage Therapy Center Introduction in English

4:34 Episode Introduction in Georgian (English subtitles)

4:53 Overview of Part 1: Overview of 100-year history of Eliava Phage Therapy Center, its advances, growth, current goals and Part 2: Scientific Rationale for phage treatment, appropriate patients, typical course of treatment, and access to care for patients worldwide

5:54 Davit's personal inspiration and history at the Eliava Center

10:27 How is EPTC raising awareness about phage therapy outside of Georgia? The center has treated patients from 84 different countries in 2023 alone. The majority of patients internationally who obtain care from EPTC suffer from various antibiotic-resistant or chronic infections.

12:20 5 million patients die from antimicrobial resistantce every year - underestimation, with tens of millions of deaths projected by 2050

13:04 Future Scientific and Commercial goals of Eliava Center to expand globally, standardize phage production to meet GMP standards, conduct randomized clinical studies and secure access for patients worldwide

15:23 Challenges in scaling phage production and quality standardization.

Georgia is currently a global leader in commercial production of bacterial phage treatments. While only a few years ago there were only a handful of clinical studies conducted globally, currently there are over 50 clinical studies in 2023-2024 alone over the past year being conducted in the United States alone. Similarly, other European countries, particularly Great Britain are also actively pursuing and advancing clinical research in bacteriophage therapies. Government and research funding in phage treatment is therefore continuing to grow rapidly.

18:33 Final Greetings - Conclusion of Part 1. Invitation to partner across Europe and the U.S. with the Eliava Phage Therapy Center