Mrs. Maxwell is a 75-year-old patient with neurocognitive disorder due to  Alzheimer’s disease. She lives with her son and his wife and generally does very well with her day-to-day activities. The family understand the importance of routine and Mrs. Maxwell maintains a regular schedule of activities including her meals, timed toileting, and recreational activities. Which of the following behaviors should prompt an immediate depression screening for Mrs. Maxwell? 

A. An acute change in mental status 

B. Angry verbal outbursts that seem unwarranted 

C. Death of her best friend 

D. An unplanned weight loss despite consistent oral intake 
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