In this episode, we explore the growing threat of xylazine — a veterinary sedative increasingly found in illicit drug supplies — and what clinicians need to know when naloxone simply isn't enough. Dr. David Gorelick breaks down the current evidence on diagnosis, treatment, and the critical gaps that remain.

Faculty: David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A., F.A.S.A.M. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Quick Take Vol. 82
• Xylazine ("Tranq Dope") Overdose: What Clinicians Should Know

In this episode, we explore how to select the right initial treatment for depression using the updated CANMAT guidelines. How do severity, patient preference, and treatment availability shape your first clinical move? Dr. Sagar Parikh breaks down the evidence on psychotherapy, antidepressants, and when to combine both.

Faculty: Sagar V. Parikh, M.D. Host: Richard Seeber, M.D.

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• Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
• Selecting the Initial Depression Treatment

In this episode, we explore the hidden dangers of leaving antipsychotics running long after a hospital delirium episode has resolved. Could a medication prescribed to keep your patient safe in the short term actually be harming them months later — and what does the latest evidence say about stopping it?

Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Quick Take Vol. 82
• Deprescribing Antipsychotics Post-Delirium: Why It Matters

In this episode, we explore the practical dosing, initiation, and conversion strategies for paliperidone palmitate and risperidone long-acting injectables in schizophrenia. How do you manage a missed six-month injection — reload or continue? Dr. Brian Miller breaks down everything you need to know to prescribe these formulations with confidence.

Faculty: Brian Miller, M.D., Ph.D., M.P.H. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Use of Long-Acting Injectable Antipsychotics in Schizophrenia
• LAIs in Practice: Paliperidone & Risperidone

In this episode, we explore the surprisingly thin evidence base behind antipsychotic switching — one of psychiatry's most common clinical maneuvers. Dr. Oliver Freudenreich breaks down a landmark systematic review and shares six practical tips to help clinicians switch antipsychotics safely and confidently.

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 82
• Switching Oral Antipsychotics: Six Strategies and Tips

In this episode, we explore the practical use of long-acting injectable antipsychotics in schizophrenia — specifically aripiprazole and olanzapine formulations. What's the right dose when a patient misses an injection? Dr. Brian Miller breaks down dosing, oral supplementation windows, and dose equivalence for Abilify Maintena, Aristada, and Zyprexa Relprevv.

Faculty: Brian Miller, M.D., Ph.D., M.P.H. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Use of Long-Acting Injectable Antipsychotics in Schizophrenia
• LAIs in Practice: Aripiprazole & Olanzapine

In this episode, we explore whether we can predict which bipolar disorder treatments will work for specific patients before months of trial and error. Could your patient's clinical profile, family history, or even their own neurons hold the key to finding the right medication sooner?

Faculty: Kristin Raj, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 81
• Can We Predict Who Responds to Mood Stabilizers?

In this episode, we explore when and why long-acting injectable antipsychotics (LAIs) should be considered for patients with schizophrenia, covering approved indications, ideal candidate profiles, and the critical role of shared decision-making in treatment planning.

Faculty: Brian Miller, M.D., Ph.D., M.P.H. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Use of Long-Acting Injectable Antipsychotics in Schizophrenia
• Understanding When to Prescribe LAIs

In this episode, we explore a striking new Nature study suggesting that lithium deficiency may play a central role in the onset of Alzheimer's disease. Could a simple, overlooked supplement be the key to prevention? Dr. Scott Beach unpacks the science, the promise, and the important caveats.

Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Quick Take Vol. 81
• Lithium Orotate: Breakthrough Treatment for Alzheimer's Disease?

In this episode, we explore the nuanced challenge of managing ADHD with stimulant medications during pregnancy. Is stopping the medication always the safer choice — or does untreated ADHD carry risks of its own? Dr. Amanda Koire breaks down the latest evidence to help clinicians make truly informed decisions.

Faculty: Amanda Koire, M.D., Ph.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know
• Pregnancy, ADHD, and Stimulants: Making an Informed Choice