Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment.

• 00:38     Nemeroff interview
• 02:27     McIntyre et al.
• 04:06     Ramaekers et al.
• 05:44     Ghaznavi et al.
• 08:01     Fonzo et al.
• 09:17     Wolfgang et al.
• 10:45     Psychedelics and psychotherapies
• 12:31     Aaronson et al.
• 14:17     Pagni et al.
• 15:31     Kirlić et al.
• 17:06     Olson

Transcript

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Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins us to discuss the rest of the December issue of AJP.

• 00:36     Grey and Knight interview
• 02:41     Demographics of the cohort
• 03:46     Neurobiological mechanisms of discrimination impacts
• 06:14     Racial discrimination and mental health impacts
• 09:34     Discrimination as a chronic stressor and prolonged activation of the stress response system
• 10:45     Limitations
• 13:52     Further research
• 14:38     Kalin interview
• 14:52     Grey et al.
• 17:35     Sippel et al.
• 18:06     Fox and Shackman
• 19:42     Kliemann et al.
• 22:16     Kamboj et al.
• 27:07     Pathak et al.

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Dr. Phuc Le (Cleveland Clinic, Case Western Reserve University, Cleveland) joins AJP Audio to discuss racial, ethnic, and sociodemographic disparities in treatment in alcohol use disorder among participants of the All of Us cohort.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the November issue, which takes a close look at issues surrounding substance use disorders.

• 00:41     Le interview
• 01:52     Disparities in treatment of AUDs in the US
• 03:43     What is the VA system doing right?
• 05:25     All of Us
• 06:39     Immediate clinical implications
• 08:15     Limitations
• 09:38     Further research
• 10:55     Kalin interview
• 11:07     Le et al.
• 13:44     Imperio et al.
• 14:43     McClure et al.
• 17:23     Perlman et al.
• 20:57     Savage et al.
• 24:17     Compton et al.

Transcript

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Dr. Bodyl Brand (Oxford University, UK) joins AJP Audio to discuss the effectiveness of menopausal hormone therapy in preventing psychosis relapse in women with schizophrenia and schizoaffective disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the October issue of the American Journal of Psychiatry, which focuses on other issues touching psychosis and schizophrenia spectrum disorders.

• 01:05     Brand interview
• 03:08     MHT and potential side effects in schizophrenia treatment
• 06:16     Estrogen and psychosis prophylaxis
• 07:44     MHT effectiveness
• 10:15     Clinical implications
• 11:27     Strengths and limitations
• 13:47     The need for further study
• 15:54     Further research
• 17:24     Kalin interview
• 17:47     Brand et al.
• 20:17     Partanen et al.
• 23:54     Moran et al.
• 26:48     Gallucci et al.
• 30:38     Arion et al.

Transcript

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Dr. Jessica Salvatore (Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey) joins AJP Audio to discuss peer social genetic effects and their impact on alcohol and substance use, anxiety, and major depressive disorders in adolescents.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the September issue of the American Journal of Psychiatry.

• 00:52     Salvatore interview
• 02:49     Can the genetic makeup of other people impact your risk for psychiatric conditions?
• 04:12     Impact on genetic predisposition
• 05:12     Why look at these effects through a genetic lens?
• 07:17     Limitations
• 10:05     Clinical implications
• 12:40     Further research
• 13:32     Kalin interview
• 13:47     Salvatore et al.
• 15:54     Dalhuisen et al.
• 19:23     Hess et al.
• 24:14     Larsen et al.
• 26:43     Schwippel et al.

Transcript

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Dr. Evan Krueger (Tulane University School of Social Work) joins AJP Audio to discuss the impact of sexual identity change and continuity on the mental health and substance use of adults who identify as a sexual minority.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of AJP.

• 00:52     Krueger interview
• 02:49     The Generations Study
• 04:21     How the sample differed
• 05:42     Differences between male and female, monosexual and plurisexual
• 07:53     Clinical implications for this population
• 09:39     Limitations
• 11:11     Life course and societal changes as potential factors?
• 13:05     Further research
• 14:31     Kalin interview
• 14:37     Krueger et al.
• 17:21     Amstadter et al.
• 20:45     Hilbert et al.
• 23:13     Bommersbach et al.
• 25:49     Zhou et al.

Transcript

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Dr. Lina Jonsson (Sahlgrenska Academy at University of Gothenburg, Sweden) joins AJP Audio to discuss the association of occupational dysfunction and hospital admissions with polygenic profiles in patients with bipolar disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of AJP.

• 00:45     Jonsson interview
• 04:35     Occupational dysfunction and hospitalization in bipolar disorder
• 05:29     Crossover between groups in patients with schizophrenia spectrum disorder
• 06:37     Clinical implications for working with patients with bipolar disorder
• 07:46     Limitations
• 09:03     Future research
• 10:14     Kalin interview
• 10:31     Jonsson et al.
• 13:43     Baum et al.
• 15:00     Kang et al.
• 18:10     Rohde et al.
• 22:06     Ironside et al.
• 26:30     Chen et al.

Transcript

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Ms. Sara Tramazzo (Stony Brook University) joins AJP Audio to discuss the long-term outlook for patients with schizophrenia spectrum disorders and other psychotic disorders over the course of 25 years.  Afterwards, Dr. Ned Kalin joins to discuss the rest of the June issue of AJP.

• 00:50     Tramazzo interview
• 01:55     Lower levels of recovery and remission than other long-term studies
• 03:01     Difficulties of following patients in long-term studies
• 04:35     Differences between recovery and remission
• 05:54     Clinical implications
• 07:49     Limitations
• 10:21     Follow up periods
• 11:17     Further research
• 12:39     Kalin interview
• 12:53     Tramazzo et al.
• 15:51     Erwin et al.
• 18:59     Van der Pluijm et al.
• 20:47     Vita et al.
• 23:08     Tamon et al.
• 25:06     Norman et al.

Transcript

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Dr. ReJoyce Green (Medical University of South Carolina, Charleston, SC) joins AJP Audio to discuss predictors of substance use initiation in a large cohort of early adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin speaks with AJP Deputy Editor Dr. Kathleen Brady about the May issue of AJP, a special issue guest edited by Dr. Brady focusing on latest developments in the understanding and treatment of substance use disorders.

Transcript

• 00:48     Green interview
• 03:04     Why is it important to study substance use initiation?
• 04:06     Social and family-related factors versus imaging and neurocognitive factors
• 05:58     Age and cohort concerns
• 07:15     Religious participation as a predictive factor
• 09:04     Clinical implications
• 11:03     Limitations
• 12:24     What’s next for your research?
• 13:36     Kalin and Brady interview
• 17:09     Green et al.
• 19:52     Morley et al.
• 23:34     Radoman et al.
• 26:21     Hoffman et al.
• 29:00     Blalock et al.

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Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability.

• 00:56     Hwang interview
• 02:09     Effects of oxytocin
• 05:45     Intranasal oxytocin
• 07:04     Potential adverse effects of oxytocin
• 08:08     Imaging
• 08:58     Preliminary investigations and clinical implications
• 09:51     Limitations
• 10:14     Further research
• 11:00     Kalin interview
• 11:33     Hwang et al.
• 14:43     Leibenluft et al.
• 15:39     Aggarwal et al.
• 18:22     Pezzoli et al.
• 21:34     Kendler et al.
• 23:30     Hou et al.

Transcript

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