Is the ever-expanding genetic landscape of Alzheimer’s disease overwhelming for you? Joseph will help you catch up on all the literature about new genes or variants linked to Alzheimer’s Disease in September 2020.

Sections in this episode:

Novel Gene Discovery - 1:08

New Variant Discovery - 10:24

Testing Associations in Novel Genes - 13:50

Miscellaneous - 18:33

In this episode, Marcia updates you on 8 papers from September 2020 on the development of treatments that target amyloid-beta mediated toxicity to treat Alzheimer's disease. Tune in to hear more!

In today’s episode, you’ll hear about the latest developments in preventing or treating AD using non-pharmacological approaches, such as cognitive interventions, stimulation techniques, and exercise. Naila covers clinical trials in humans and mechanistic studies in animal models, all in 19 papers. Enjoy!

Interested in the behavioural aspects of AD such as changes to cognition, emotion, sleep, sensory and verbal abilities, and learning and memory? Look no further. Anusha will guide you through the literature that was published on these topics in September (2020) to help you start the new year off on the right foot.

Sections in this episode:

1.47 Cognition/Emotional Processing/Depression

10.35 Sleep

17.24 Verbal/Audition/Olfaction

25.04 Learning and Memory

Happy New Year from the AMiNDR team! In our first episode of 2021, Abdullah presents on the modulation of inflammatory response in AD, with a big emphasis on microglia, the forgotten heroes in his mind, they clean, repair and protect your brain. Hopefully by the end of the episode you’ll know more about why changing their behaviour could be the treatment we are looking for.

Sections in this episode:

Targeting NLRP3: 2:00

Favouring M2 over M1 for microglia: 5:57

Other: 11:00

Interested in the mission to accurately diagnose Alzheimer’s disease with a blood test? This episode is perfect for you. In this two-part episode on Fluid Biomarkers in AD from September 2020 papers, Elyn explains the ATN framework for AD diagnosis, and covers papers focused on fluid biomarkers relating to amyloid, tau, and neurodegeneration. She also touches on a few new methods for biomarkers researchers. Tune in to hear about how storage conditions can affect measurements, how assay platforms compare, and new methods for isolating exosomes!

Sections in this episode:

Combination of the Classics: 3:44

Amyloid beta: 16:45

Neurofilament Light: 22:32

Methods: 23:50

In this episode, Jacques will tell you about new peer-reviewed publications from September 2020 on mechanisms of APP processing and protein aggregation in the context of Alzheimer's disease. This includes aggregation of amyloid-beta as well as other proteins such as tau and alpha-synuclein. Enjoy the episode!

In this episode, Marcia covers papers published in September 2020 that focus on the latest in novel drug development in AD. We especially talk about papers targeting amyloid-beta aggregation, BACE-1 inhibitors, gamma-secretase, immunotherapy for AD and more! Tune in to learn more.

Is your research on diet and nutrition and Alzheimer’s disease? Or maybe you are diving deeper into the role of carbs and fat metabolism, and are interested in mitochondrial function in neurodegenerative diseases? Then stay here! Sarah covers 13 papers from our September 2020 harvest with topics ranging from the ketogenic diet to the lipidome.

List of sections:

Diet and nutrition: 2.18

Carbohydrate and lipid metabolism: 5.44

Protective aspects of metabolism: 14.23

Mechanisms of mitochondrial function and dysfunction: 18.00

Elyn is back to cover the latest findings relating to the cerebrovasculature in Alzheimer disease! In this two part episode covering papers from September 2020, you’ll hear about how aging and systemic inflammation can influence the blood-brain barrier, how circulating “good cholesterol” can protect the blood vessels and may be dysfunctional in AD, and a whole lot about cerebral small vessel disease.