In the first of 3 episodes on AD risk factors for September 2020, Naila covers some of the most studied (arguably) modifiable risk factors, including diet, exercise and sleep. You'll also hear about the effects of hormones and common comorbidities such as diabetes and cardiovascular disease. As many of these factors relate to one another, this will give you a good overview of the literature on common AD risk factors in September 2020!

Major Sections:

Diet (1.00)

Body Mass, Diabetes, Cardiovascular Factors (6.54)

Exercise (15.30)

Hormones, Circadian Rhythm, Sleep (23.17)

Are you invested in the role of neurotransmission in Alzheimer’s disease? Well then buckle in because in this episode, Anusha will go over the latest and greatest compounds that target disease state changes to synaptic transmission in animal and in vitro models of Alzheimer’s.

This episode covers the papers published in September of 2020 that use animal models and tissue culture to test the effects of novel compounds for their effects in rescuing synaptic transmission changes in AD. We’ll have 8 papers on cholinergic system, 3 on the glutamatergic neurotransmission, and 1 on G-protein coupled receptors.

Major Sections:

The Cholinergic System (1.44)

The Glutamatergic System (15.15)

G-Protein Coupled Receptors (21.40)

Sarah and Elyn are joined by Kyle and Drake from BrainBuzz Podcast to share our journey, growth, and challenges with starting a podcast for science communication in Psychology for them, and Neuroscience for us. What is it like to talk about our research at cocktail parties? What does starting a podcast require? How does one manage to say "neurodegenerative" without stuttering?

This is the second of two crossover episodes. Listen to the first part on Apple Podcast on BrainBuzz: https://podcasts.apple.com/ca/podcast/brain-buzz/id1334344532

There, you will hear Elyn talk about her research on blood biomarkers in Alzheimer's disease, and Sarah share why she needed a podcast like AMiNDR during her grad studies.

We hope you enjoy! As always, if you have any questions or suggestions, please reach out at [email protected]

In this episode, Elyn takes you through a very diverse set of papers on Alzheimer’s disease mechanisms - catching all of the papers that didn’t slot nicely into other episodes. The topics span a wide range from how the reflex of your pupils adjusting to light may be an early indicator of AD, to potentially pathogenic crystals in post-mortem AD brain tissue. There are also several RNA-based papers and signalling pathway papers in the mix, so tune in to learn something new!

Today’s episode is on protein expression, aggregation, misfolding and pathology, with an emphasis on tau pathology in Alzheimer’s Disease and we are rounding off the papers published in August 2020. If you are interested in tau spreading in neurodegenerative disease, protein dysfunction in disease and new potential therapeutic targets, Alyssa has got you covered.

Naila is back to round off our risk factors section with an episode on genome-wide association studies, transcriptomic research, combining genetics and neuroimaging data, and new tools to make all this work easier. Tune in to learn more about the techniques used to study the genetic underpinnings of AD, and perhaps to learn some long gene names to impress people at the next party you attend - especially if you can still remember them by then.

With over 700km of blood vessels in the brain, it’s no surprise that brain and vascular health are closely related. In this episode, Elyn takes you through papers published in August 2020 on cerebrovascular changes in AD. Tune in to learn more about amyloid clearance, platelet aggregation, and changes in the neurovascular unit over the course of the disease.

Today’s episode is all about Diagnostic Tools and Imaging papers published in August 2020. As you will soon see, these papers explore a wide range of topics including potential biomarkers of AD, hormone markers and EEG analyses. While these papers didn’t quite fit into some of the other diagnostic tools and Imaging subthemes discussed in previous and upcoming episodes (such cognitive testing, imaging tools, fluid biomarkers, and using Amyloid and tau level for diagnosis and classification), they are just as important. So tune in to find out more!

In this episode, Alex will be covering papers published in August 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment, and a few papers that don’t quite fit under any of the themes we’ve covered so far. We’ll take a look at studies targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation.

Naila covers a wide variety of biomarkers and topics from papers published in August 2020 on Alzheimer's disease: identifying biomarkers of cognition and memory in cognitively unimpaired older adults, biomarkers that can help predict AD progression and differentiation, new biomarker assays and tools for improved diagnosis, using EEG and metabolic profiling...