For today's episode, Naila is back to take you through 20 papers on prevention and intervention strategies in Alzheimer's. You'll be treated to the latest on mindfulness and meditation, the default mode network's involvement in Alzheimer's, strategies for assessing and optimizing therapies, stimulation techniques and more. Enjoy!

Sections in this episode:

Innovation assessment (3:08)

Cognitive Training (6:36)

Mindfulness and Movement (13:39)

Diet (26:00)

Sensory Stimulation (30:24)

Neuromodulatory Techniques (39:45)

In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD.

Sections in this episode:

Drug Discovery and Development of Novel Therapeutics (3:49)

Testing Existing Compounds (17:27)

Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this one!

Sections in this episode:

Behavioural Changes (3:30)

Learning History(13:45)

Depressive Symptoms(15:32)

Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode!

Sections in this episode:

Glutamate and Acetylcholine (4:01)

GABA neurons (10:52)

Neuron Excitability (12:15)

Synaptic Proteins (15:10)

Neuro-Immuno-Endocrine System (21:45)

Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more!

Sections in this episode:

Hippocampus (3:50)

Hypothalamus (8:15)

Cortical regions (10:29)

Nucleus basalis (15:57)

Pineal gland (18:40)

Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in!

Sections in this episode:

Targeting Neurotoxicity in vitro (3:53)

Invertebrate models of AD (8:41)

Transgenic AD models (14:48)

Other AD models (22:47)

In today's episode, there's a big focus on sleep in Alzheimer's disease, as well as other clinical and pharmacological studies that dive into the cognitive and behavioural deficits. We even have one paper that looks into character strengths in AD, so definitely join Judy and follow along in this unique episode from our October 2022 series!

Sections in this episode:

Sleep (2:53)

Behavioural changes in rodent models (7:00)

Behavioural changes in humans (10:02)

Cognitive changes in rodent models (14:46)

Depressive symptoms (18:09)

Other cognitive changes in humans (21:10)

In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrovasculature in brain health. Tune in to learn more about the glymphatic system, consequences of amyloid deposition on the vasculature, and a clinical study testing out albumin replacement as an AD treatment!

Sections in this episode:

Vascular Implications of Amyloid Accumulation (3:52)

Glymphatic System (7:31)

Other Clinical Studies (10:57)

Co-morbidities and Risk Factors (15:20)

Treatment Avenues (22:15)

Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins.

We have one last episode for you to wrap up 2022! In this episode, Naila will guide you through 11 papers published in August 2022, covering a range of ways researchers are working on preventing or treating aspects of Alzheimer's disease through non-pharmacological therapies. You'll hear about cognitive training tools, the effects of disrupting circadian rhythms on metabolism and Alzheimer's, and on vagal nerve stimulation for treating neuropsychiatric symptoms related to AD. You may also hear the occasional interjection from her needy cat. See you in 2023!

Sections in this episode:

Cognitive Training (2:10)

Exercise and Metabolism (10:07)

Neuromodulatory Techniques (20:35)