We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what you’re interested in, stay tuned!

Sections in this episode:

Special Mention of Blots in a Field? (3:39)

Network Dysfunction (4:53)

Synaptic Dysfunction (12:09)

Molecular Changes (22:33)

Today's episode includes 15 papers on non-pharmacological treatments and complementary therapies for AD. Naila will take you through research published in June 2022 on an array of topics including olfactory training, beer, choir participation, light therapy, and transcranial magnetic stimulation. You'll be treated to research on both the human and animal level, with a special focus on targeting neuroinflammation and brain connectivity!

Sections in this episode:

Cognitive Training and Complementary Therapies (2:44)

Diet and Exercise (15:38)

Light Therapy (21:57)

Electrical and Magnetic Stimulation (29:46)

We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver.

Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts, all presented in this episode!

Sections in this episode:

Combinign Multiple Neurocognitive Domains (7.00)

Activities of Daily Living (14.00)

Digital Tools & Automation (18.30)

Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms.

Sections in this episode:

Human Subjects Research (2:52)

AD Pathology (11:19)

Mechanism (15:12)

Targeting Memory Impairment with Genetic Manipulation (10:51)

Targeting Synaptic Function (15:17)

In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned!

Sections in this episode:

Genetic & Disease Overlaps (2:15)

RNA & Transcriptomics (5:10)

Genetic Testing (10:25)

GWAS Studies (15:24)

Specific Genes (21:04)

Extra (28:55)

Anusha brings you 12 papers today on the development of treatments that target neuroprotection in Alzheimer's disease. This includes a range of research models, from in silico and drug discovery studies, to rodent models of AD. Enjoy!

Sections in this episode:

In Silico and Drug Discovery Studies (2:27)

Testing Phytochemicals in AD Rodent Models (7:29)

This episode contains a whole range of topics in cognitive and behavioural changes in AD! Tune in as Judy covers a variety of papers published in June 2022, spanning from from sensory processing in mouse models to antidepressants in human patients. There's bound to be something that piques your interest!

Sections in this episode:

Studies Using Mouse Models (2:03)

Sensory Processing (7:15)

Behavioural Changes in AD (13:08)

Cognitive Changes in AD (15:49)

Neuropsychiatric Changes in AD (19:45)

You are here, with us, right now, about to get the updates you eagerly wait for every month in Alzheimer’s disease research. A whole episode dedicated to assessing neurocognitive domains for screening and diagnostics. Learning and memory? Executive function? Perceptual and motor skills? You got it! 7 abstracts published in June 2022, nicely packaged for you in this podcast.

Sections in this episode:

Learning & Memory (7:41)

Executive Function (26:18)

Perceptual-Motor (28:25)

Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on vascular pathology in familial Alzheimer disease, and so much more. Tune in for a riveting episode!

Sections in this episode:

Cardiovascular Risk Factors (4:06)

Interactions of Vascular Pathology with AD Hallmarks (6:58)

Vascular Abnormalities in Familial AD (12:28)

APOE, Retinal Imaging, and Proteomics (18:12)

Treatments Targeting the Vasculature (23:22)

We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode is a great place to start!

Sections in this episode:

Changes to neurotransmission and neuronal excitability (2.44)

Changes to movement/learning and memory (11.06)