Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too!

Sections in this episode:

Synaptic Connectivity Changes (1.44)

APP/Tau contribution to Synaptic Dysfunction (7.47)

In February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials.

Sections in this episode:

Drug Discovery (2.01)

Drug Development (4.59)

Clinical Trials (11.58)

February 2022 was full of abstracts using unique therapeutic approaches to target Alzheimer's disease. Cassi presents abstracts on both naturally-occurring and pharmaceutical compounds used to treat various neurodegenerative pathology and symptoms.

Sections in this episode:

Microbiome (1:55)

NF-kappaB signaling pathway (6:12)

Sexual dimorphism (11:34)

Naturally-occurring & pharmaceutical treatments (15:37)

In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com!

Sections in this episode:

Epidemiological Studies (1:56)

Racial/Ethnic Disparities (11:50)

Social Determinants (25:24)

Lifestyle and Environmental Factors (31:44)

Welcome back for the continuation of our segment on clinical assessment. You heard about testing specific neurocognitive domains in part 1, and here we’re back to cover abstracts that look at the big picture in assessing cognitive function. We’re presenting 8 abstracts published in February 2022, perfect for you if you’re interested in tracking cognitive decline for the diagnosis of Alzheimer’s disease, Mild Cognitive Impairment, or dementia in general.

Sections in this episode:

Considerations and Limitations in Testing (3.06)

The Big Picture (13.30)

If you wanted to detect and diagnose Alzheimer’s disease, or assess disease progression, what aspects of cognition would you focus on? In other words, what capabilities would you test to decide if someone is indeed experiencing cognitive decline, had Alzheimer’s disease, or another type of dementia? And what tools could you use? Stay with me to hear about the abstracts dedicated to specific cognitive domains in the clinical assessment of cognitive impairment, published in February 2022!

Sections in this episode:

Learning and Memory (6.04)

Language (21.42)

This month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to offer, and plenty of other stimulating topics!

Sections in this episode:

Cognitive and Multidomain Interventions (1:35)

Diet (7:42)

Exercise (12:00)

Neuromodulatory Techniques (26:20)

Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in the context of Alzheimer disease in this episode covering papers published on PubMed in February 2022.

Sections in this episode:

Clinical Insights: Neuroimaging and Vascular Risk Factors (3:51)

Preclinical Insights: Methodology and BBB Regulation (25:47)

Treatment Avenues (32:19)

In Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology.

Sections in this episode:

Cardiovascular Factors (2:35)

BMI (12:25)

Diabetes and Related Conditions (14:49)

In Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, and if you want to cover even more, look out for Part 2 coming soon!

Sections in this episode:

Sociodemographic and Lifestyle Factors (2:11)

Miscellaneous Health Factors (15:01)