Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis!

Clinical Studies (3:53)

Preclinical Studies/Methology (12:41)

Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopeful about future therapeutic directions!

Drug Discovery/Development (1:52)

Targeting Neuronal Functions (9:19)

Targeting Neuroprotection (14:25)

In this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more!

Sensory Processing (1:45)

Mouse Models (5:44)

Clinical Treatments (8:34)

Sleep (12:59)

Other (17:29)

In this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies!

GWAS and Polygenic Risk Scores (2:20)

Cognitive & Social Genetic Studies (8:42)

Tool development (11:46)

Gene Discovery (14:41)

Studies on Amyloid and Tau (16:09)

Welcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impairment, Alzheimer’s disease, or dementia in general.

Learning and Memory (7:17)

Perceptual and Motor Skills (20:23)

Language (22:33)

Activities of Daily Living (27:56)

AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic!

Sections in this episode:

Calcium Homeostasis (2:54)

Synaptic Function in Animal Models (5:26)

Human Models (10:28)

In the final episode of the March 2022 series, Naila takes you through 18 papers on non-pharmacological strategies for preventing or treating Alzheimer's disease. You'll hear the latest from animal studies on exercise, learn about the potential benefits of brown rice, pet ownership and yoga, and be guided through a number of techniques that are being used to modulate brain activity with the hopes of improving cognition or slowing disease progression. Enjoy!

Note: We will be skipping the month of April 2022, and moving on to papers published in May 2022 for our next series. Episodes for the May series will be released in July 2022! In the meantime, catch up on our almost 300 episodes covering research on Alzheimer's Disease going all the way back to 2020.

Sections in this episode:

Exercise (3:31)

Other Lifestyle Factors (15:51)

Neuromodulatory Techniques (24:31)

Welcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that may help us refine our diagnosis, or even for prognostic purposes. Yes, you read this correctly, all this goodness packed in 1 episode!

Sections in this episode:

Evaluating Existing Tests (7:31)

Identifying Markers for Cognitive Decline (23:14)

This is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looking at activities of daily living. This is perfect for you if you are researching cognition, or are interested in Neurology or Geriatrics in general!

Sections in this episode:

Learning & Memory (6:40)

Language (14:48)

Perceptual-Motor (20:43)

Attention (23:44)

Other (25:54)

Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too?

Sections in this episode:

Stem Cell-Based Therapy (3.01)

Testing compounds in A-Beta AD Models (4.52)

Testing compounds in APP/PS1 AD Model (14.49)

Test compounds in other AD Models (17.15)