With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022!

Sections in this episode:

Clinical Insights - Vascular Risk Factors (3:46)

Blood-Brain Barrier Dysfunction (9:41)

Amyloid Deposition and Clearance (30:31)

Treatment Avenues (35:22)

Pssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models.

Sections in this episode:

Treatments using stem cells (2.18)

Protecting against A-beta induced toxicity (4.59)

Protecting against glutamate-induced cytotoxicity (9.20)

Treatments tested in transgenic AD-like mice (12.38)

Treatments tested in AD rat models (17.13)

What information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD.

Sections in this episode:

Gray and white matter changes (2.25)

Correlations of structural changes with biomarkers (9.28)

Methods for early detection (15.27)

Software packages for brain volumetry (19.03)

Radiomic (22.56)

Today's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects of repetitive transcranial magnetic stimulation, and more!

Sections in this episode:

Interventions Targeting Cognition (1.50)

Multidomain Interventions (7.36)

Nutrition (13.30)

Exercise (19.06)

Stimulatory Techniques (25.23)

We start off our January 2022 series of AMiNDR with this episode highlighting 9 papers on changes to synaptic transmission in Alzheimer's Disease. In this episode, Anusha will cover topics including changes to GABAergic and glutamatergic transmission and calcium flux in AD-affected neurons. We also have papers looking at age-dependent changes in synaptic function in AD. End NEURO-transmission ;)

Sections in this episode:

Changes to GABAergic transmission (2.41)

Changes to calcium flux (6.42)

Changes to glutamateric transmission (8.38)

Age-dependent changes in AD (13.11)

Discover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD.

Sections in this episode:

Prevalence and Socioeconomic Factors (1:45)

Nutrition (13:11)

Health-Related Factors (18:49)

In this short and sweet episode, Anusha will take you through 7 papers published in December of 2021 on the subject of treatments targeting neuronal and synaptic protection in AD. Exercise your cognitive reserve by tuning into this episode!

Sections in this episode:

Testing Naturally-Derived Compounds (3.35)

Testing Pre-Existing Drugs (10.54)

Tickled by tau? Preoccupied with post-translational modifications? Join Kate as she covers the latest papers published in December 2021 on tau protein pathology and targeting tau as a therapeutic strategy in Alzheimer's disease.

Sections in this episode:

Tau Aggregation & Post-Translational Modifications (3:19)

Generalized Tau Pathology & Tau Seeding (7:29)

Treatments Targeting Tau in AD (13:50)

Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter.

Sections in this episode:

Insights from Clinical Studies (4:10)

Insights from Animal Models (14:47)

In today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy!

Sections in this episode:

Cognition and Sleep (1.34)

Exercise (6.28)

Neuromodulatory Techniques (12.16)