In today's episode, Naila will guide you through 10 papers that were published in November 2021 on preventing and treating Alzheimer's disease. You'll hear about snoring, caffeine consumption, the mechanisms underlying exercise, and a bunch of neuromodulatory techniques that could treat certain aspects of AD. Hopefully you'll find this latest research to be stimulating!

Sections in this episode:

Modifiable Risk Factors (2:02)

Neuromodulatory Techniques (8:55)

You have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through this journey of curiosity.

Sections in this episode:

Synaptic Changes in AD Mouse Models (2.27)

AD-related changes to Lipid Regulation (11.25)

To kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research all about cognition and behavioural symptoms in AD.

Sections in this episode:

Mild Behavioural Impairment (3:31)

Perception (5:35)

Stress & Psychiatric Disturbances (7:28)

Sleep (15:47)

Potential Treatments for AD (20:20)

In this special episode of AMiNDR, we sit down with Jenn Kim and Lucy Aceves, two of the creators of the graduate student-run Neuropsyched Magazine! We talk all things graduate school and academia -- from useful tips for choosing a PI, our experiences of grad school during the pandemic, financial barriers we have faced, and establishing boundaries. We also tell you about Neuropsyched magazine, and what working in science communication means to all of us! This conversation was a blast to have and we think you'll have a blast listening to it too, no matter where you are in your academic career -- enjoy the show!

Topics we chat about:

Grad school surprises (2:04)

Grad school during the pandemic (12:35)

Mentorship in academia (22:46)

Applying for labs & choosing a PI (31:32)

What is Neuropsyched? (47:29)

Transferable skills from SciComm (49:41)

Finances in grad school (1:01:23)

Establishing boundaries (1:10:49)

Naila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers!

Sections in this episode:

Lifestyle factors (1:39)

Nutrition (7:08)

Physical and Psychiatric Comorbities (13:30)

In Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2!

Sections in this episode:

Prevalence and Demographics (1:33)

Education (7:51)

Socioeconomic status and occupation (14:13)

Other (23:38)

Thinking about thinking? Changes to synaptic transmission contribute to Alzheimer's disease pathology. Hear all about 10 papers published in October of 2021 exploring synaptic dysfunction in AD from Anusha who hosts this episode.

Sections in this episode:

Synaptic dysfunction in rodent AD models (2.58)

Synaptic dysfunction in other AD models & human studies (16.44)

Elyn is back with your monthly update on vascular contributions to Alzheimer disease! This month she covers 8 papers that primarily focus on the blood-brain barrier, and white matter hyperintensities that reflect cerebrovascular abnormalities. Tune in for some exciting new findings in the field and more data emphasizing the importance of vascular health in dementia.

Sections in this episode:

White Matter Hyperintensities (4:13)

Blood-Brain Barrier (13:57)

Cerebral Amyloid Angiopathy (20:02)

New year, new papers! Join Kate for your monthly update on all things proteostasis and autophagy as they relate to both AD pathology and potential new therapeutic interventions. In today's papers, we'll journey through the endolysosomal system, say "Hi" to some new chaperone families, and even discuss the interplay between AD and other distinct neurodegenerative diseases. Enjoy!

Sections in this episode:

Autophagy & Proteostasis Pathology (4:42)

Targeting Proteostasis/Autophagy Machinery (28:48)

Welcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in!

Sections in this episode:

Transcriptomics/Gene Expression Changes (2:33)

Genetic Variants (6:16)

Genetic Risk (13:14)

MicroRNA (20:10)

Other Topics (22:52)