Ellen tells you about research on topics such as cognitive reserve, reinforcement learning, psychiatric conditions, sleep issues, speech, and more in this jam-packed episode on cognitive and behavioural changes in Alzheimer's Disease.

Sections in this episode:

General Cognition (3:32)

Reinforcement Learning (14:09)

Speech and Language (16:33)

Visuospatial and Motor Control (25:06)

Psychiatric Changes (28:15)

Sleep and Circadian Rhythms (35:16)

Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases.

Sections in this episode:

Epidemiology / Multiple Factors (1:00)

Immune Conditions (8:00)

Metabolic and Cardiovascular (15:00)

Neurological Comorbidities (24:50)

In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2!

Sections in this episode:

Lifestyle & Environmental Factors (2:09)

Hormones (15:13)

Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following up on in the near future to advance our understanding of the disease!

Sections in this episode:

Genetic variants (3:11)

Genetic biomarkers (13:58)

Differential gene expression and mRNA (18:05)

miRNA regulations (22:55)

New methods (26:42)

Regulatory pathways (30:00)

Other (33:49)

Tune into this month's episode on the latest research on autophagy and proteostasis in Alzheimer's Disease. This includes papers on how autophagy and protein homeostasis are dysfunctional in this disease, and potential treatments that target these cellular pathways. Enjoy!

Sections in this episode:

Proteostatic and autophagic dysregulation (4:33)

RNA splicing, binding, and signaling (10:32)

Glycans, glycoproteins, and fatty acids (19:29)

Amyloid precursor protein (24:16)

Targeting Proteostasis/Autophagy Machinery (26:55)

Let’s take a trip with Vee through the latest literature to the mitochondria and learn about oxidative stress, metabolism and related therapeutics in Alzheimer’s disease pathology. A jam packed session from vitamins to energy homeostasis to metal chelators- this episode has it all! We have 10 publications from September 2021, which will surely “power” your interest. Tune in and get ready to charge up on the exciting research!

Sections in this episode:

Metabolism (4:26)

Mitochondria (11:45)

Oxidative Stress (19:47)

Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode.

Sections in this episode:

Amyloid-based detection (2.35)

Tau-based detection (9.35)

Amyloid & Tau (21.30)

Other targets (24.25)

Tired of untangling the tricky world of tau literature all on your own? Interested in the mechanisms of tau pathology, therapeutic advancements targeting tau, or both? Join Kate for another exciting episode covering 20 new papers published in September 2021. We’ll explore tau aggregation, regulation, and treatment development through a wide variety of model systems, from molecular dynamics all the way to human subjects - so, tune in to learn more!

Sections in this episode:

New tau pathological findings (3.17)

Tau and Neuroinflammation (7.46)

Tau Aggregation (10.24)

Tau Pathology from Prion-like Seeding Behaviour (13.24)

Treatments Targeting Tau (24.59)

18 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature.

Sections in this episode:

Discovery and synthesis of novel cholinesterase inhibitors (3.17)

Tacrine-based cholinesterase inhibitors (11.26)

Modifying existing treatments (16.16)

Multi-target treatments (23.00)

Are you interested in neuronal hyperexcitability, impairments in synaptic plasticity, and interactions between amyloid plaques and synaptic proteins in Alzheimer's disease pathology? You've come to the right podcast! In this episode, Glory will guide you through 11 publications from September 2021 on the latest research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease. Hit that play button to hear all of the exciting new insights on the AD synapse.

Sections in this episode:

Neurotransmitters systems involved in AD (2:56)

Neuronal structure (11:42)

Neuron Excitability (14:33)

Amyloid beta and APP at the synapse (18:12)