The first episode of our September 2021 series gets us acclimated with papers that target neuronal and synaptic function in preclinical studies of Azheimer's disease. Join Anusha and she walks you through papers that explore topics like rescuing amyloid beta-induced toxicity, restoring neuronal morphology, and using animal models of Alzheimer's disease to target neuronal function.

Sections in this episode:

Targeting A-Beta-Induced Toxicity (2.21)

Restoring Neuronal Morphology and Promoting Neurogenesis (7.26)

Restoring Neuronal Function in AD Animal Models (15.40)

This is part 2 of our episode on clinical markers for Alzheimer’s disease, where we cover papers published in August 2021. How does a translation of your favourite cognitive test perform in a Chinese, Slovenian or Persian population? What measures are we currently ignoring but should be include in our battery of tests to detect Alzheimer’s disease or mild cognitive impairment? There is new stuff on this regularly, so come get your monthly fill of research news, maybe you’ll find a gem that will influence your practice, in research or in the clinic.

Sections in this episode:

Validating variations of an existing test (4.10)

New parameters to include in cognitive testing (14.45)

Do you want to brush up on your knowledge of MoCA, ADAS-Cog, the MMSE and other cognitive tests? Join Sarah to hear about the 7 papers published in August 2021 where we’re evaluating existing tests for their specificity and sensitivity in detecting Alzheimer's disease and mild cognitive impairment.

In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD!

Sections in this episode:

Cognitive Profiles (4:07)

Executive Functions (13:06)

Exercise & Cognition (18:12)

Psychiatric & Social Symptoms (21:54)

Motor Coordination & Balance (34:09)

Sleep & Circadian Rhythms (35:52)

Are you familiar with protein aggregation in Alzheimer's disease, but want to learn more about the mechanisms cells use to fight back against these stubborn species? Join Kate in exploring the landscape of cellular processes governing proteostasis and autophagy as they relate to AD. In this short-but-sweet episode, we'll cover a total of 7 papers focused on AD pathology involving autophagy and/or proteostasis dysfunction, as well as treatments targeting these processes. If you're new to these terms, or in need of a cell bio refresher, don't sweat it! - we'll be kicking off the episode with a quick primer on both topics, so sit back and enjoy!

Sections in this episode:

Proteostasis and Autophagic Dysregulation in AD Pathology (4:57)

Targeting Proteostasis or Autophagy for Treatments in AD (16:05)

Buckle down and get ready for a lengthy episode on the most recently discovered familial mutations and variants related to Alzheimer's disease. With Glory as your host, we'll take a look at different variants in genes that may make you more or less susceptible to developing AD. A large chunk of the episode will cover single nucleotide polymorphisms that have been found in various populations and correlate with neurodegenerative disease. You’ll also hear about genetic mutations in patients or families that researchers have linked to familial AD.

Sections in this episode:

SNPs and risk variants (3:18)

Sex-specific genetic factors (15:56)

Genomics studies (19:51)

Familial AD mutations - Presenilin (25:20)

Familial AD mutations - Amyloid-Beta/APP (30:41)

Join Marcia as she explores the what’s, how’s, and why’s of all things oxidative stress, mitochondrial dysfunction and metabolism in AD. With this month’s - August 2021- papers, you’ll hear about the latest related cell and animal model studies, AD-adjunct diabetes, and even about potential therapeutics! So sit back and enjoy!

Sections in this episode:

Metabolism (2.40)

Oxidative Stress (11.02)

Mitochondrial Dysfunction (22.25)

Make yourself comfortable, because we cover a lot of ground in today's episode. Naila will guide you through 24 papers from August 2021, all pertaining to epidemiological studies on the risk and protective factors related to AD. You'll hear about some basic epidemiology, environmental and socioeconomic risk factors, lifestyle factors, and health conditions related to AD.

Sections in this episode:

Epidemiology & Social Factors (1.52)

Diet (16.53)

Sleep (24.19)

Comorbidities (28.00)

Tired of the age-old amyloid cascade hypothesis? Think there's more to Alzheimer disease than amyloid and tau? Join Elyn in unpacking the latest literature on vascular contributions to Alzheimer disease from papers published in August 2021. This is another relatively short one, packed with exciting new insights!

Sections in this episode:

Cardiovasular Risk Factors (4:30)

White Matter Hyperintensities and Cerebral Small Vessel Disease (8:28)

Vascular Changes: Perivascular Spaces, Pericyte Coverage, & Vessel Density (16:22)

Want to know more about about how the brain's different neurotransmitter systems aren't functioning properly in Alzheimer's disease and how hippocampal synaptic plasticity impairment contributes to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease pathology. With this month's new papers, August 2021 gives us 12 publications that try to answer all of your questions on the synaptic aspects of AD! You're sure to get your own synapses firing by listening to this episode!

Sections in this episode:

Neurotransmitters and neuropeptides (3:01)

Electrophysiological changes (10:08)

Synaptic plasticity (12:28)

New AD models (14:24)

Cognition and memory (18:58)