Interested in how the 700km of blood vessels in the brain are linked to Alzheimer disease? Turns out there are a lot of common threads! In this episode, Elyn covers a series of clinical and preclinical papers exploring vascular risk factors, genetic risk factors like APOE, and signs of vascular damage that are linked to Alzheimer disease. Tune in for an exciting perspective on Alzheimer disease, outside of the classic amyloid cascade hypothesis!

Sections in this episode:

Clinical Studies: Cardiovascular Risk Factors and Cerebrovascular Pathology (4:22)

Lymphatic/Glymphatic Drainage (13:48)

Preclinical Modelling (17:13)

In this shorter episode, Judy covers studies on structural and functional connectivity changes in AD, as well as new methods of integrating multimodal neuroimaging data. All 9 papers were published in July 2021 and focus on improving AD diagnosis using deep learning, specific fMRI measures and more - be sure to check it out!

Sections in this episode:

fMRI (2:11)

Default Mode Network (8:16)

Other (10:10)

Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic!

Sections in this episode:

Treatments targeting neuroprotection (1.03)

Mechanism of treatments targeting neuroprotection (11.14)

Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show!

Sections in this episode:

Sensory processing & function (3:31)

Speech (9:16)

Learning & memory (11:17)

Psychiatric changes (13:50)

Sleep (21:20)

Glory's back for another episode with all the latest updates on research about how disruptions in certain mechanisms of synaptic transmission and plasticity contribute to Alzheimer's disease. We'll be featuring 14 papers published in July 2021 that cover all things synaptic in AD, including ion channel function and LTP! Join us for an episode that's sure to stimulate your own synapses!

Sections in this episode:

Neurotransmitters (3:00)

Neuronal excitability/activity (11:29)

Structural (17:15)

Synaptic Plasticity (23:15)

Memory (29:52)

“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’!

Sections in this episode:

Gene expression and transcriptomics (02:26)

Proteomics (17:38)

Curious about oxidative stress, default mode network markers and EEG patterns associated with Alzheimer's disease? Join us for an exciting episode on metabolic changes, hemodynamics and EEG featuring papers published in July 2021! Studies include conventional and newer methods of improving AD diagnosis, such as recording electrical activity from the outer ear using electrovestibulography or tracking brain metabolite changes in real time with functional magnetic resonance spectroscopy. Come hear about the latest research!

Sections in this episode:

Metabolic Changes (2:08)

Hemodynamics (13:05)

EEG (17:34)

In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons!

Sections in this episode:

Novel Anti-Cholinesterase Drugs (2.39)

Existing Anti-Cholinesterase Drugs (16.28)

Targeting Glutamate (26.17)

In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in!

Sections in this episode:

Technology for AD and MCI (2:08)

Semantic Memory(8:11)

Test for Aspects of Cognition (11:38)

Oculomotor Markers of Cognition (20:50)

Language Adaptations (23:03)

Naila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy!

Sections in this episode:

Prevalence, incidence, multiple factors (2:08)

Cardiovascular (20:33)

Other health conditions (25:30)

Protective (40:52)