Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it.

Sections in this episode:

Amyloid-beta based detection (1:30)

Tau based detection (9:45)

Amyloid-beta and tau (15:04)

Case studies (16:48)

Other PET targets (19:01)

Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new!

Sections in this episode:

fMRI (01:32)

Machine Learning (12:10)

Other (14:36)

With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers paper on the plasma lipidome!

Sections in this episode:

Clinical Studies – Neuroimaging and Cardiovascular Risk (4:20)

Mechanistic Studies – BBB dysfunction and rescue (13:20)

Bonus paper on Plasma lipidome (17:38)

Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity.

Sections in this episode:

APP Processing & Secretases (3.15)

Characterizing Aggregate Content (7.00)

Amyloid-β Aggregation (10.09)

Downstream effects of Amyloid-β (25.16)

In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques.

Sections in this episode:

Exercise (1:37)

Multidomain / Other (7:05)

Neuromodulatory Techniques (15:20)

Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley.

Sections in this episode:

Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03)

Neuroprotection in other AD models (12.51)

In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more!

Sections in this episode:

Metabolic changes in AD (1:20)

Hemodynamics (9:30)

EEG (13:30)

Curious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and stimulate your own synapses!

Sections in this episode:

Synapse Function and Plasticity (2:17)

Neurotransmitter Systems Affected in AD (11:04)

Neuronal Hyperactivity and Calcium Signaling (18:45)

Spatial Memory (24:30)

Animal Models (29:30)

We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021.

Sections in this episode:

Transcription and differential gene expression (02:12)

Methylation (09:56)

Multiomics (13:29)

Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you!

Sections in this episode:

Cognition & Attention (3:32)

Memory (9:59)

Speech & Communication (16:31)

Gait (23:05)

Psychiatric Symptoms (26:58)

Sleep & Circadian Rhythms (30:32)