From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis!

Sections in this episode:

Clinical Testing (1:58)

Motor Assessments (7:39)

Semantic Dementia (11:28)

Sleep (14:03)

In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests.

Sections in this episode:

General cognition (2:00)

Visual, verbal, and auditory testing (13:50)

Other dementia subtypes (18:43)

Machine learning (25.08)

Language and cultural adaptations (29.32)

In the second part of our episodes on amyloid-beta, we focus on the ways amyloid-beta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau! Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people of Westeros…or...wages a war on neurons. Enjoy!

Sections in this episode:

Amyloid-beta toxicity: (9:05)

Iron Dyshomeostasis: (18:13)

Prion-Like Seeding & Spread: (24:19)

Miscellaneous: (33:25)

This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis.

Sections in this episode:

Targeting cholinesterases and oxidative stress (1.56)

Targeting glutamate and excitotoxicity (22.33)

Targeting Adrenergic Receptor (26.58)

Wow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics.

Sections in this episode:

Methods for Gene and Pathway Discovery (1:46)

GWAS, Transcriptome, Exome Sequencing (5:47)

Miscellaneous (12:55)

Familial AD (17:11)

In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode!

Sections in this episode:

Microglia (02:07)

Astrocytes (10:42)

TREM2 (13:34)

Metabolism (18:08)

Periphery (24:53)

In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy!

Sections in this episode:

Depression (2:27)

Anxiety (5:26)

Stress & PTSD (9:55)

Agitation (13:30)

Emotional Reactivity (17:13)

Sleep & Circadian Rhythms (19:12)

Hello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role Amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then Amyloid-beta generation and aggregation. We will also throw a teaser on Amyloid-beta detection with a focus on plaques, so stay tuned if you need an update far from the screen while enjoying a walk, transiting to work, or going about your house chores.

Are you ready?

Sections in this episode:

APP Processing, Localization, & Amyloid-beta Generation (6.25)

Amyloid-beta Aggregation (14.45)

Plaque Structure & Characterization (25.45)

In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities.

Sections in this episode:

Tau Based Detection (1:48)

A-beta Based Detection (10:45)

Tau and A-beta (18:10)

Other PET Targets (19:33)

In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon!

Sections in this episode:

Cognition in AD patients (4:09)

Cognition in animal models (9:38)

Motor impairments (19:00)