From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new!

Sections in this episode:

Hemodynamics (1:05)

Metabolic Changes (9:45)

EEG (16:30)

Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance!

Sections in this episode:

Using Pre-existing Synthetic Compounds (2.21)

Using Naturally Occurring Compounds (12.36)

Drug Design (26.35)

In this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies for AD.

Sections in this episode:

Diet (2:52)

Exercise (9:01)

Multidomain Interventions (26.21)

Cognitive training (34:29)

Neuromodulatory techniques (37:30)

Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis!

Sections in this episode:

Overlap Between Cardiovascular Disease and AD (3:56)

Clinical Studies on Cerebrovascular Pathology (12:20)

Microvascular and Blood-Brain Barrier Changes in AD (16:03)

Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more!

Sections in this episode:

fMRI (2:00)

MRI (10:51)

Other (15:43)

In this episode, Courtney takes you through the papers from May 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on genetic risk factors, biomarkers associated with ApoE status, risk factors for AD and finally, molecular mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode!

Sections in this episode:

Genetic Risk Factors (2:12)

Biomarkers in Alzheimer's Disease (7:15)

Risk Factors of Alzheimer's Disease (12:10)

Mechanisms of ApoE in Alzheimer's Disease (18:07)

Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show!

Sections in this episode:

Neurogenesis (5:11)

Synaptic Plasticity (8:46)

Neurotransmitter Signaling (18:26)

Excitation/Inhibition Balance (28.07)

Growth Factors (32:16)

Morphological & Anatomical Changes (35:46)

If you are interested in oxidative stress in Alzheimer’s disease, mitochondrial dysfunction, or metabolism, come hear about the ways they can be targeted for therapeutic purposes. Maybe you are tired of hearing about cholinesterase inhibitors or anti-amyloid-beta antibodies and want to explore something different. Tune in with Sarah in this last episode for our series on the papers published in March 2021. She covers 17 abstracts that harness the interconnectedness between mechanisms involved in AD pathology to develop new therapeutics and repurpose others (used in diabetes, hypertension, depression,…)

Ready. Set. Play!

Sections in this episode:

Targeting oxidative stress (4:00)

Targeting mitochondria (14:40)

Targeting metabolism (with a focus on diabetes and insulin) (21:47)

Targeting metabolism (with a focus on cholesterol) (30:48)

In this short episode, Joseph goes over 9 studies published in March 2021 that include GWAS’s, ethnicity-specific genetic studies and research on familial AD genetics. Tune in to learn more!

Sections in this episode:

GWAS and other population level studies (2:22)

Ethnicity Specific Studies (7:44)

Familial AD Genetics (11:28)

Jacques takes you on a journey through 22 papers on amyloid-beta & aggregation. Ranging from new techniques for amyloid-beta detection, APP-processing, co-pathology & Prion-like mechanisms and some miscellaneous topics pioneering the AD field. Guess you'll just have to stick around until the end!

Sections in this episode:

Amyloid-beta processing (2:02)

Amyloid-beta detection (13:00)

Amyloid-beta membrane interactions (18:35)

Proteins controlling aggregation, prion protein & prion-like transmission (29:20)

Amyloid-beta & Inflammation (41:17)

Miscellaneous (45:35)