In this episode, you'll hear about the latest research on targeting neuroinflammation, glial cells, autophagy and proteoastis to treat Alzheimer's Disease. This includes some studies that want to increase neuroinflammation and some that want to decrease it! How can they both work? You'll have to listen to find out.

Sections in this episode:

Treatments targeting Neuroinflammation and Neurodegeneration (3:31)

Proteostasis and Autophagy (24:58)

In Part 2 of Clinical Markers of AD, Naila will take you through 10 papers on the diagnostic and prognostic value of neuropsychiatric, sensory, motor, or a combination of symptoms. You'll learn about pareidolia, extrapyramidal symptoms, wandering behaviour and more!

Sections in this episode:

Multiple Symptoms (2:47)

Neuropsychiatric Symptoms (6:51)

Sensory Symptoms (11:05)

Motor Symptoms (18:23)

In part 1 of the clinical markers of AD episodes, Ellen will tell you about papers from March 2021 all about cognition. This includes papers on new cognitive tests, improving or adapting old ones to new situations, learning more about how useful these different assessments really are, AND some really cool papers at the end on new technology and machine learning tools to make AD diagnosis and detection even better!

Sections in this episode:

Multi-Domain Cognitive Testing (3:16)

Naming & Recall (11:41)

Executive Function (17:06)

Emotion Recognition (19:11)

Amyloid-beta & Cognitive Decline (22:06)

Machine Learning & Technology (26:14)

Transcriptional and translational dysregulation may cause changes in cellular biology and can lead to disease. In this episode, Marcia brings you the latest research in March 2020 that focus on changes in gene & protein expression and epigenetics in the context of Alzheimer’s disease. Some common terms you’ll hear throughout this episode are transcriptomics, methylome, biomarkers, proteomics, AD models, etc. We also touch upon the up-and-coming field of multiomics, so tune in to hear more!

Sections in this episode:

Gene expression and transcriptomics (2:03)

Gene expression of truncated proteins (7:11)

Model organisms in AD (12:05)

Non-coding RNA (19:33)

Methylation/epigenetics (25:20)

Translation and protein folding (30:34)

In today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets. Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models.

Sections in this episode:

Amyloid/Tau PET Targets

Tau pathology (1:08)

PET image processing and data analysis (6:45)

Animal models (11:53)

Miscellaneous (14:47)

Other PET Targets

Butyrylcholinesterase (17:50)

Miscellaneous (20:43)

We've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021!

In this episode, Courtney takes you through the papers from March of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, systemic inflammation and so much more! Tune in for this exciting episode!

Sections in this episode:

Systemic Inflammation (2.02)

Neuroinflammation in Humans (6.27)

Astrocytes in AD (9.41)

Microglia in AD (13.24)

Neuroinflammation in Animal Models (27.38)

Tune in as Ellen updates you on all things cognition and behaviour in Alzheimer's disease. Particularly, she'll tell you about new studies from March 2021 that shed light on the characteristics of cognitive and behavioural symptoms in AD, and the underlying neural mechanisms. This episode covers a lot of ground -- memory, executive function, the sense of smell, depression, chewing, and so much more! You're sure to learn a lot in this jam-packed episode.

Sections in this episode:

Characterizing Cognitive Changes in AD (2:27)

Underlying Neuropathology of Cognitive Symptoms (8:23)

Olfaction (15:28)

Psychiatric & Emotional Changes (22:09)

Sleep & Circadian Rhythms (30:20)

Other Topics (35:16)

Tired of the age-old amyloid cascade hypothesis? So is Elyn! Join her in this episode unpacking papers that showed up on PubMed in March 2021 that add more evidence to the tight intertwinement of vascular and brain health. Topics in this episode range from mechanistic studies in animal models looking at cerebral blood flow and blood-brain barrier integrity, all the way to clinical studies mapping out cerebrovascular damage across the AD continuum. This is a shorter episode, with only 13 papers covered - perfect for a commute to work or a leisurely bike ride!

Sections in this episode:

Overlap Between Cardiovascular Disease and AD (3:48)

Clinical Studies on Cerebrovascular Pathology (12:03)

Mechanisms of Blood-Brain Barrier Disruption (18:00)

AD Treatments Targeting the Vasculature (21:14)

In this shorter episode, Judy goes through metabolic changes, hemodynamics and functional connectivity papers on Alzheimer's disease, all published in March 2021. Aside from our favorites PET, MRI and EEG, we also look into studies that use less common techniques like SPECT imaging, retinography and MEG. Join us for just 20 minutes of neuroimaging fun!

Sections in this episode:

PET (1:05)

MRI (5:27)

EEG (10:24)

Other (13:01)