Follow along with Glory in this episode, as we dive into papers that try to uncover the link between changes in synaptic transmission and plasticity with cognitive decline and memory loss in Alzheimer's disease. We'll discuss the most recent research on molecular and structural mechanisms at the synapse that underlie Alzheimer's pathology! Tune in for topics such as presynaptic SNAREs, postsynaptic ion channels, neurotransmitter signalling and more!

Sections in this episode:

Synapse Structure/Organization (2:11)

Presynaptic and Postsynaptic Proteins (3:29)

Neurotransmitters (6:32)

Synaptic Plasticity (10:44)

Cognition (16:41)

Learning and Memory (19:48)

In part 2 of epidemiological studies from March 2021, a particularly loopy, end-of-week Naila will take you through 22 papers on comorbidities and health conditions linked to Alzheimer's disease. We've got some papers on general frailty and comorbidity burden, treatments for other diseases, sleep apnea, cardiovascular risk factors and vision impairment.

In part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD!

Anusha will be summarizing for you papers published in March of 2021 that address neuronal and synaptic health in models of Alzheimer’s disease. That’s not all! We are also going to explore the topic of restoring neurotransmitter balance. So if for instance, you’re looking for research on acetylcholinesterase inhibition, this episode is for you!

Sections in this episode:

Targeting neuro/synaptic protection with peptides (2.29)

Using existing drugs (9.42)

Disease mechanisms (17.26)

Targeting acetylcholine (21.03)

Targeting GABA (26.10)

Drug discovery (27.57)

Drug development (33.02)

Hooray! The first episode of our March 2021 series is here! In this episode, Courtney takes you through the papers from March 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on ApoE in cognition, ApoE on biomarkers and pathology, and mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode!

Sections in this episode:

Impact of ApoE on Cognition (2:06)

Biomarkers in AD (8:43)

Metabolism (14:37)

Molecular Mechanisms of ApoE (18:52)

Twin studies, GWAS, TWAS, EWAS and more - In this episode, Joseph takes you through 20 papers published in February 2021 that explore novel genes or variants associated with Alzheimer’s Disease, studied associations of novel pathways to AD or link molecular pathways of other diseases to AD.

Sections in this episode:

Comorbidities and other conditions (1:28)

Identification and Validation of Risk Genes and Loci (9:10)

Changes in the Brain (21:02)

New Tools Development (26:01)

Miscellaneous (29:42)

Ellen is bringing you Part 2 of our series on cognitive & clinical indicators to diagnose AD! Make sure to check out episode 143 for Part 1! In Part 2, you'll learn about the latest research validating old & new cognitive tests for AD and mild cognitive impairment, how motor and muscular symptoms can be used to diagnose AD, how body temperature relates to this disease, and the latest in machine learning technology to distinguish AD patients from cognitively normal individuals.

Sections in this episode:

Cognitive Assessments & Screening Tools (3:07)

Motor & Muscular Deficits (16:00)

Body Temperature (22:00)

Machine Learning Tools (23:49)

In part 1, Naila will take you through 17 papers on characterizing different cognitive profiles of Alzheimer's disease, comparing cognitive measures to pathological biomarkers, optimizing visual and memory tasks, and examining how subjective measures of cognitive decline relate to objective tests. Be sure to check out Part 2 for test validation, motor tasks, and machine learning!

Sections in this episode:

Cognitive Profiles & Trajectories (2:10)

Visual Tasks (12:50)

Behaviour, Memory & Subjective Measures (19:29)

Marcia is back to bring you the latest in Alzheimer's disease treatment development! Join us as we explore the complex relationship between AD and metabolic disorders like diabetes, and some therapies used to co-treat them. Not enough? We also talk about oxidative stress and mitochondrial dysfunction, and (some new!) compounds aimed at mitigating these. Tune in to get your neurons firing!

Sections in this episode:

1) Metabolism: 00:58

2) Oxidative stress: 10:15

3) Mitochondria: 21:20

Naila provides an overview of February 2021 papers related to preventative factors and non-pharmacological interventions for AD. You'll hear about physical activity, the ketogenic diet, transcranial magnetic stimulation, and dogs! Quite the range in just 20 papers.

Sections in this episode:

Lifestyle/Multiple Factors (1.56)

Physical Activity (5.27)

Diet (14.45)

Social/Emotional Wellbeing (18.50)

Stimulation/Neuromodulatory Techniques (28.38)