Curious about ketogenic diets, insomnia and loneliness? Then this episode is just for you! Join Naila as she goes through 23 new epidemiological studies of AD that were published in February 2021, and cover a wide range of potential risk or protective factors of AD.

Sections in this episode:

Disease prevalence and progression (1:56)

Air pollution (4:42)

Smoking and Atherosclerosis (9:04)

Psychosocial (14:04)

Comorbidities and Sleep (22:59)

Other Risk Factors (29:41)

In this episode, Courtney takes you through the papers from February 2021 on understanding ApoE in Alzheimer's disease and through a few papers on the familial mutations in Alzheimer's disease. There is a wide range of topics so be sure tune in for this exciting episode!

Sections in this episode:

Cognitive impairment with APOE (2:30)

Brain banks to model and predict AD progression (8:56)

Mechanisms of APOE (13:11)

Familial mutations (17:42)

To kick of the February 2021 series, Anusha guides you through papers recently published that target synaptic health and acetylcholinesterase activity to uncover pathological mechanisms that underlie Alzheimer's disease. If you like thinking about thinking, look no further than this episode!

Sections in this episode:

Synaptic Plasticity and Preservation (2:05)

Oxidative Stress (8:52)

Miscellaneous (12:37)

Acetylcholinesterase Inhibitor Rivastigmine (17:47)

Novel Inhibitors (21:36)

Welcome to the baptists, the tauists, and all protein aggregation and misfolding enthusiasts from the beautiful realm of neuroscience. This episode is for you if you study amyloid-beta aggregation and toxicity in Alzheimer's disease. You will hear about fibrillar assembly, staining techniques to identify those sneaky aggregates, and strategies to inhibit this process in the hope of developing targeted therapeutics. Come hear condensed summaries of the findings published in January 2021 on this topic!

Sections in this episode:

Disease Mechanisms of Amyloid-Beta Aggregation (3.47)

Targeting Amyloid-Beta Aggregation (18.36)

In this episode we’ll cover all things metabolism, hemodynamics and connectivity in the brain, in AD. We’ll cover 26 papers published in January 2021, that dive deeper into these research topics, so tune in!

Sections in this episode:

Metabolism (1:42)

Hemodynamic (4:28)

Connectivity changes (11:46)

Miscellaneous (24:56)

Join Naila for 24 papers published in January 2021 on preventive strategies and non-pharmacological interventions for treating AD. She’ll catch you up on the latest exercise interventions, the various diets under investigation for AD prevention, invasive and non-invasive stimulation techniques, cognitive therapy and a few miscellaneous papers.

Sections in this episode:

Exercise and Physical Activity (2.09)

Diet and Obesity (20.46)

Cognitive and Psychological Interventions (34.01)

Stimulation Techniques/Non-Invasive and Invasive Techniques (40.36)

Miscellaneous Interventions (50.46)

Anusha is your guide through 14 papers which target neurotransmitter balance. These papers were all published in January 2021 and focus mostly on targeting acetylcholinesterase activity with a sprinkling of other targets such as NMDA receptors. If you love synapses and are dying to find out how we can get them working properly again in AD, make sure to give this episode a listen!

Sections in this episode:

Targeting Acetylcholinesterase Activity (2:25)

Other targets (18:33)

In this episode, Maria covers papers from January 2021 exploring cognitive and neuropsychiatric assessments that can be used to evaluate early AD or progression to AD. The studies look at tests and questionnaires related to learning and memory, functional status, and neuropsychiatric symptoms, including online adaptations of cognitive assessments when in-person visits are not always possible.

Sections in this episode:

Different tests for learning and memory as potential MCI or AD biomarkers (1:54)

Assessments of function (17:19)

Neuropsychiatric Tests (20:31)

Online platforms to assess early cognitive changes (27:42)

In this episode, Courtney takes you through the papers from 2021 on the role of Immune systems and glial cells in Alzheimer's disease pathology. The papers relate to neuroimaging, astrocytes, microglia, and broader inflammatory topics and pathways. Be sure to tune in for this exciting episode!

Sections in this episode:

Neuroimaging and Alzheimer's disease (2:01)

Methods of studying inflammation (5:40)

LPS-induced inflammation (7:59)

Astrocytes (11:40)

Microglia Neuropathology (15:27)

Molecular mechanisms of Microglia (20:22)

Gut inflammation and the brain (30:25)

Inflammation in general (33:41)

In this episode, the first of a two-part mini series, Jacques runs through papers from January 2021 on amyloid-beta oligomers in aggregation and therapeutics strategies to target them. Tune in to hear about conformational changes, molecules that affect oligomerisation, oligomer conformation-specific treatment strategies and more!

Sections in this episode:

Oligomerization/Conformation, etc. (2:25)

Strategies targeting oligomers (19:06)