The rapidly evolving field of Alzheimer’s research is always discovering new genes, variants or even pathways that are associated with this disease. In this episode, Joseph goes over 14 studies from January 2021 that explored novel genes or novel variants, or even studied the associations of novel pathways with AD.

Sections in this episode:

Association studies with gene networks and polygenic risk scores (2:19)

Commonly known genes and pathways (10:14)

Mitochondria (19:09)

Learn about the studies from January 2021 that used imaging to investigate structural changes in Alzheimer's disease. This includes imaging of different brain regions, as well as other structures like the retina. By better understanding these changes, we can learn more about the disease's pathology and mechanisms, which could lead us to the ability to better treat this disease, or detect it at earlier stages.

Sections in this episode:

Deep Learning (01:22)

Specific Brain Regions (18:54)

Eyes (22:09)

Misc. (25:52)

In this episode, Marcia will take you through papers from January 2021 that involve research on targeting mitochondria, metabolism and oxidative stress as effective therapeutic strategies against AD. Tune in to hear about the relation between AD, diet and metabolic diseases like diabetes, the use of nanotechnology and organelle-specific agents to deliver therapy, and more!

Sections in this episode:

Oxidative Stress (1:00)

Metabolism (11:55)

Mitochondria (18:45)

Ellen covers papers published this past January on cognitive and neuropsychiatric symptoms in AD and the mechanisms behind them. You'll hear about sensory processing, cognitive and memory deficits, psychiatric symptoms and emotions, and sleep and circadian rhythms in the context of AD. Tune in to learn about the potential mechanisms behind these symptoms, and how they correspond to disease progression.

Sections in this episode:

Sensory Processing (Olfaction, Vision, and Pain) (3:41)

Cognition & Memory (13:32)

Psychiatric Symptoms & Emotions (18:37)

Sleep & Circadian Rhythms (23:35)

In this episode, Abdullah will cover the latest papers from January 2021 covering development of potential treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out-of-the-box ideas like how rotten eggs and silver apricots may hold therapeutic benefits for Alzheimer's Disease.

Sections in the episode:

Microglia (3:46)

Astrocytes (7:17)

Glial cells in general (11:43)

Proteostasis & Autophagy (22:49)

This longer episode features amyloid and tau detection in the brain, as well as new PET targets of AD! Judy discusses papers from January 2021 that include topics such as AD mouse models, deep learning methods and several different PET tracers. Tune in to find out more!

Sections in this episode:

PET (1:54)

Non-PET (32:51)

New PET Targets (35:22)

In Part 2 of mechanisms underlying AD risk factors, you'll learn about comorbidities ranging from traumatic brain injury to schizophrenia, hear a little bit about hearing loss, and be exposed to some research on exposure to toxic metals. Naila is your host for today, and will take you through 13 papers from January 2021!

Sections in this episode:

Comorbidities (2.10)

Noise/Hearing Loss (12.02)

Toxic Metal Exposure (16.59)

Neuroprotective Factors (24.49)

In this episode, Naila covers the first half of peer-reviewed papers publish in January 2021 on mechanisms underlying risk factors of Alzheimer's disease. In 11 papers, she'll go through diabetes, cardiovascular disease and sleep troubles. Enjoy, and check out Part 2 for more!

Sections in this episode:

Diabetes (1:39)

Cardiovascular (5:22)

Sleep (17:15)

In today’s episode, Marcia brings you the latest research from Jan 2021 on changes to RNA, Transcription and Translation in the context of Alzheimer’s disease. We also talk about some really in-fashion techniques like multi-omics, deconvolution, mendelian randomization and co-localization. Tune in to learn about these techniques and more!

Sections in this episode:

Multiomics (2 papers) 1:10

Mendelian randomization and colocalization (3) 3:45

Gene pathway and network analysis (2) 7:21

Differential gene expression/deconvolution (2) 9:41

Methylation (2) 12:35

Post translational modifications (2) 15:19

microRNAs (3) 17:38

Miscellaneous (2) 22:53

In this episode, Glory will take you through the papers published on alterations to synaptic transmission and structure in Alzheimer's disease from January 2021. Tune in for all things synaptic - including glutamate receptor signalling, long-term potentiation and dendritic spine integrity!

Sections in this episode:

Neurotransmitter signaling: 1.45

Synaptic plasticity: 13.55

Synapse structure: 16.40

Memory: 19.20