Deciding what to do during your lunch break or out on a stroll? Well, look no further! Listen in on Abdullah covering the latest papers from February 2021 covering the treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out of the box ideas that may hold therapeutic benefits for Alzheimer's Disease.

Sections in this episode:

Targeting the Immune System & Glial Cells (3:43)

Targeting Proteostasis & Autophagy (20:15)

Judy covers a wide range of neuroimaging modalities in the context of metabolics, hemodynamics and functional connectivity in AD. Tune in if you're a fan of fMRI, PET and EEG, or if you're just looking to learn something new!

Sections in this episode:

fMRI (1:06)

PET (7:28)

EEG (16:29)

fNIRS (20:16)

Other (23:12)

Elyn is back to guide your through all of the connections between blood vessels and Alzheimer disease, published in February 2021. Starting the episode off with how midlife vascular risk factors can influence AD risk, and finishing with treatments for AD that target the vasculature, you're sure to leave this episode appreciating how intertwined heart health and brain health are. Well worth the longer listen for all of the new insight!

Sections in this episode:

Midlife Vascular Risk Factors for AD (3.16)

Associations of Cerebrovascular Pathology with AD Pathology and Clinical Progression (11.09)

Streamlining Quantification of Vascular Pathology (21.16)

Mechanisms of AD in the Vasculature (25.54)

AD Treatments Targeting the Vasculature (30.14)

In this short episode packed full of insight, Jacques navigates the realms of amyloid-beta toxicity in AD. Learn about different techniques and models used to investigate amyloid-beta toxicity, how mouse models can provide insight into toxic amyloid-beta species and the relationship of certain amyloid-beta species with clinical presentations.

Sections in this episode:

Techniques for Investigating Amyloid-beta Toxicity (2:17)

Amyloid-beta Toxicity within Different Cell Types and Species (5:53)

Mouse models of Alzheimer’s Disease(12:52)

Amyloid-beta Toxicity and Humans (17:01)

Courtney guides you through the latest papers on the immune system and glial cells in the context of Alzheimer's Disease. This includes papers on microglia, astrocytes, and advances in methods to study inflammation in neuroscience. Enjoy!

Sections in this episode:

Microglial Pathway and Receptors (2:44)

Tying Microglia to Astrocytes (19:37)

Astrocytes (22:20)

Models and Methods to Study Inflammation (29:03)

Follow along with Alex in this episode, as we take a closer look at papers studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets at the end of the episode. We'll cover topics including deep learning, cerebral amyloid angiopathy, and using the retina as a way of indirectly accessing the brain!

Sections in this episode:

Amyloid and tau-based detection (1:30)

Subsection: Animal models (10:00)

Subsection: Deep learning (12:25)

Subsection: Cerebral amyloid angiopathy (15:07)

Other pet targets (17:24)

A huge focus of Alzheimer's Disease research is understanding the mechanisms behind behavioural symptoms and how to treat them. In this episode, Ellen takes you through papers published in February on topics such as autobiographical memory, sex differences, decision-making, sensory processing, depression, sleep, and so much more!

Sections in this episode:

Cognition (2:43)

Sensory processing (9:07)

Gait disturbances (15:00)

Psychiatric symptoms (18:22)

Sleep (24:31)

Marcia is back to update you on the latest Alzheimer's research. Today's episode is all about RNA, transcription, translation, proteomics, and more, all in the context of AD. Enjoy.

Sections in this episode:

RNA & Transcription (1:00)

Translation & Proteomics ( 12:28)

Miscellaneous (16:26)

Want to learn more about how changes in synaptic function, structure and plasticity are implicated in neurodegenerative disease pathology? We've got you covered with this episode! Glory will guide you through 18 papers from February 2021 that explore mechanisms which underlie the synaptic dysfunction that can lead to Alzheimer's disease, ranging from the molecular level to the more global level of brain-wide connectivity.

Sections in this episode:

Synaptic and Axonal Function (1:59)

Brain Connectivity and Neuronal Networks (4:07)

Metabolites and Neurotransmitters (7:20)

Synaptic Plasticity (14:29)

Brain Injury (22:33)

In this episode, Jacques runs through February 2021's papers on APP processing and amyloid-beta aggregation. Learn about key residues underlying amyloid-beta aggregation, fibrillogenesis-promoting factors and interesting co-pathologies!

Sections in this episode:

APP processing (1:35)

Amyloid beta aggregation (10:50)