“Changes to the expression of genes may influence the delicate balance between disease and health”. If you want to learn about how that is relevant to Alzheimer’s disease, you’ve come to the right place! Join Marcia for this short episode, as she discusses how & why gene expression, its epigenetic regulation and integrative studies are important in Alzheimer’s disease!

Sections in this episode:

Transcriptome (2:35)

Multiomics (8:19)

Epigenetics (12:03)

Today, Kate will be focusing on everything tau-related in 12 papers published in August 2021, including aspects of tau pathology and exploring potential therapeutics targeting tau in Alzheimer’s disease!

Sections in this episode:

Tau Aggregation & Post-Translational Modifications (PTMs) (3.16)

Tau Pathology & Seeding (13.30)

Targeting Tau for Treatment (20.10)

This is an episode that explores the creation and testing of drugs that aim to restore neurotransmitter balance in Alzheimer's disease. It covers 14 papers that were all published in August of 2021, and Anusha will guide you through papers on targets including cholinesterases, serotonin, and glutamate receptors. Hit that play button if you'd like to hear more.

Sections in this episode:

Targeting acetylcholine with novel compounds (2.29)

Other targets with novel compounds (13.23)

Testing for or improving upon existing ACE inhibitors (17.28)

In this short and sweet episode, Naila covers 7 new papers on prevention and intervention of Alzheimer's disease. You'll hear about upcoming clinical trials of behavioural and cognitive interventions, a little bit about the mechanisms underlying the therapeutic effects of exercise, and about non-invasive stimulation techniques for treating AD.

Sections in this episode:

Cognitive / Physical Training (1:57)

Neuromodulatory Techniques (9:27)

Another month passed means another month of literature for AMiNDR to bring to you! This time, Anusha will be highlighting papers from August of 2021 that are about treatments targeting neuroprotection and synaptic activity in Alzheimer's disease. Beginning with computation and cuvettes and ending with clinical trials, we have 15 papers for your perusal so check out this episode if this topic tickles your fancy.

Sections in this episode:

Drug discovery and testing in vitro (2.26)

Testing potential compounds in AD models (7.06)

Phase II Clinical Trials (21.42)

Today's episode covers 18 papers on prevention and intervention strategies for Alzheimer's disease and dementia. Naila will take you through clinical trials and animal studies on cognitive training programs, complementary therapies, diet, exercise, and neuromodulatory techniques. There's a lot of unique papers in this one, so we hope you enjoy!

Sections in this episode:

Cognitive Training (2:52)

Complementary Therapies (6:08)

Diet (15:30) ; Exercise (19:56)

Neuromodulatory Techniques (28:51)

Journey through the entire spectrum of drug development as Anusha guides you through 19 papers that were published in July of 2021. We span research that begins with drug discovery all the way to the end goal: Phase II clinical trials. If you're interested in targeting levels of acetylcholine and monoamines, you're really going to like this episode!

Sections in this episode:

Synthesis and Discovery of Cholinesterase Inhibitors (2.47)

Drug Interactions with Multiple targets (9.29)

Pre-clinical Trials (18.23)

Clinical Trials (25.39)

In this episode, Ellen tells you about 9 papers that have developed new ways to screen for dementia. Some of these are old, tried-and-true cognitive screening tools that are given a new twist, others are brand new technology that bring cognitive testing to the modern age. You’re sure to find something you enjoy in this episode if you do neurodegenerative disease research, or even if you don’t!

Sections in this episode:

Technology-based tools (3:44)

Adapting tests to other languages (8:34)

Other new tools for testing cognition (12:22)

In the first part of this 2-parter episode, Ellen covers studies that compare and contrast different cognitive tests, or analysis techniques, for diagnosing AD at early stages, or predicting the conversion of pre-dementia stages to Alzheimer’s Disease. There are also some studies that compare cognitive abilities between different types of dementia. You'll hear about memory, spatial awareness, social cognition, and more!

Sections in this episode:

Cognitive decline & memory (3:32)

Semantic fluency (16:42)

Social cognition (18:21)

Spatial awareness (21:47)

Kate brings you the latest research on tau pathology in Alzheimer's Disease. This includes post-translational modifications, tau aggregation and seeding, and targeting tau in treatment development. Enjoy!

Sections in this episode:

Tau Pathology (4:35)

Post-translational modifications (4:56)

Tau aggregation and seeding behaviour (16:30)

Targeting Tau for Treatment Development (21:09)