Moderator: BobbieJean Sweitzer, M.D. Participants: Rutger van der Schrier, M.D., Ph.D. and Steven L. Shafer, M.D Articles Discussed: Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic–Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression Toward More Physiologic Models for Predicting the Impact of Opioids on Ventilation

Moderator: BobbieJean Sweitzer, M.D. Participants: Taiki Kojima, M.D., M.P.H. and Clyde Matava, M.B.Ch.B.., M.Med., M.H.S.C.   Articles Discussed:  Adverse Events Associated with Airway Management in Pediatric Anesthesia: A Prospective, Multicenter, Observational Japan Pediatric Difficult Airway in Anesthesia (J-PEDIA) Study     Airway Management Issues in Japanese Children Are No Different: Insights from the J-PEDIA Study

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Moderator: James Rathmell, M.D. Participants: Osama Abou-Arab, M.D. PH.D. and Matthieu Legrand, M.D., Ph.D. Articles Discussed: Early Use of Norepinephrine in High-risk Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial Preventing Hypotension during Induction of General Anesthesia: Is Preemptive Norepinephrine the Answer?

Creator: James P. Rathmell, M.D.

November 2025, Volume 143, Issue 5

Overview of November issue original studies.

Creator: James P. Rathmell, M.D.

October 2025, Volume 143, Issue 4

Overview of October issue original studies.

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Moderator: James Rathmell, M.D. Participants: Ji-Hyun Lee, M.D., Ph.D. and Andrew J. Davidson, M.D., M.B.B.S. Articles Discussed: Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial The Second Randomized Trial to Suggest You Shouldn’t Change Your Anesthetic in Infants to Avoid Neurotoxicty

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Moderator: James Rathmell, M.D. Participants: Shiqian Shen, M.D. and Cyrus David Mintz, M.D., Ph.D. Articles Discussed: Hippocampal Neural Dynamics and Postoperative Delirium-Like Behavior in Aged Mice Neural Network Dynamics of Postoperative Delirium: is it all About Neurons Striking the Right Balance?

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Moderator: BobbieJean Sweitzer, M.D. Participants: Bernd Saugel, M.D. and Michael R. Mathis, M.D. Articles Discussed: The StatistiCal Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement Cardiac Output Measurement and Reporting: More Than Just Going With the Flow

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Creator: James P. Rathmell, M.D.

September 2025, Volume 143, Issue 3

Overview of September issue original studies.

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Moderator: James P. Rathmell, M.D. Participants: Nikolay O. Kamenshchikov, M.D. and Lorenzo Berra, M.D. and Kamrouz Ghadimi, M.D.

Articles Discussed: Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial): A Randomized Controlled Trial Nitric Oxide and Kidney Injury after Cardiac Surgery: A Solution Looking for a Problem