Figure 1. National Drug-Involved
Overdose Deaths-
-Number Among All
Ages, by Gender, 1999-2020. Nearly 92,000
persons in the U.S. died from drug-involved
overdose in 2020, including illicit drugs and
prescription opioids. The figure above is a
bar and line graph showing the total
number of U.S. drug overdose deaths
involving any illicit or prescription opioid
drug from 1999 to 2020. The bars are
overlaid by lines showing the number of
deaths by gender from 1999 to 2020