Non coding RNA may regulate melanogenesis and in combination with plasma cell producing IgG the nutritional regulation of satiety.

Aging results in alterations of this complex system thus resulting in localized melanogenesis and a corruption of the HPA axis.

References:

Aging (Albany NY). 2021 Jan 31; 13(2): 2700–2726.

Stem Cells Int. 2020; 2020: 1047896. First Published online 2020 Jul 8

PNAS. 2002 Dec 24;99(26):17155-60

Components of metabolic sequence toward gluconeogenesis in the human liver.

Dr. Guerra details the glucagon and epinephrine mediated control through Stimulatory G-protein couple adenylate cyclase activating PKA over Hepatic Glycolysis and Gluconeogenesis. 

Utilization of a protein cysteine SH derived thioester intermediate alters the free energy hurdle for the synthesis of 1,3 bis PGA thus allowing for glycolytic ATP and NADH synthesis.

The interaction of glycolysis and lactic acid transport from skeletal muscle to the liver plays a significant role in oxygen uptake, transport and release in association with pulmonary carbon dioxide efflux . Dr. Daniel J. Guerra. An Authentic Biochemistry Production 19.8.21.

Any chronic decrease in the ability for molecular oxygen to bind to circulating Hb will diminish its availability in the Central Nervous System and Skeletal Muscle resulting in the potential for long-term Pathophysiology and Illness. Dr. Dan Guerra Published 11 August 2021. Authentic Biochemistry.

Classical Amino Acid Degradation Biochemistry : Emphasis on pathway interconversions and production of bioactive amines

J Physiol. 2005 563:285-90

Eur J Appl Physiol(2011) 111:2837–2843

Biomedicines. 2020 Aug 6;8(8):277.

Journal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464