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The human neuroendocrine system is directly regulated and in communication with the autonomic nervous system via cortical and diencephalonomic CNS nuclei. These converging networks coordinate satiety, glycemia, bioenergetics, oxygen transport, dietary input, digestion and muscular activity in direct association with pancreatic insulin/glucagon ratio dynamics.
References
Molecular Neurobiology volume 56, pages769–796 (2019)
Molecular Neurobiology volume 56, pages7950–7965 (2019)
Introduction to motor neuron structure/function relationships and the MND's including Amyotrophic Lateral Sclerosis.
The CNS processes nutritional (biochemical) signaling from the external and internal environment during and subsequent to dietary ingestion. During the initiation phase, affective (limbic) and executive (PFC/OFC) attention is facilitative toward ingestive behavior linked to appetitive hunger stimulation via neural, visceral, and endocrine networking including memory cues that obtain opportunity to consume pleasurable high caloric density nutrition.
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https://www.genecards.org/cgi-bin/carddisp.pl?gene=TUB
Pharmacokinetics are discussed.
Dopaminenergic pathways are corrupted by addictive behaviors especially the use/abuse of psychoactive drugs that may become behavioral reward saliencies linked to epigenomic modifications.
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Biol Psychiatry. 2020 Jan 1; 87(1): 64–73
Front. Neurosci., 26 November 2019
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