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Authentic Biochemistry
Authentic Biochemistry episodes
- Pharmacodynamics: General Considerations and Clinical Trials. Dr. Dan Guerra. Authentic Biochemistry 12 June 2021
In this episode Dr. Guerra provides the overview of Pharmacodynamics .
30 min - Pharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.
A.D.M.E.
Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492.
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30 min - Cardiovascular disease risk and malnutrition are associated with aging morbidity and obesity. Dr. Guerra. 8 June 2021. Authentic Biochemistry
Risk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization.
The immune response becomes compromised during aging leading to states of hyperinflammation followed by hypo-immune sequalae opening up the potential for opportunistic respiratory infections and alterations in pulmonary endothelial membrane lipid fluidity restricting oxygen intake.
29 min - Ceramide mediated pathophysiology of aging-associated neurodegeneration. Dr. Dan Guerra. Authentic Biochemistry.05 June 2021.
Seminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126
Pharmaceutical Research March 2018, 35:49
Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182
J. Lipid Res. 2018 59:(3) 488-506.
29 min - Immuno Endocrine Regulation of Metabolism May-June 2021. Dr. Dan Guerra Authentic Biochemistry.
Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020
Molecular Neurodegeneration volume 7, Article number: 45 (2012)
J Biol Chem. 2019 Jun 7;294(23):9213-9224
30 min - Aging and Cancer Via Immunosenescence and Pro-inflammatory Cytokines: Relative loss of Naive T cell Populations in the Elderly. DJGPhD. 26 March 2021
Annu. Rev. Physiol. 2013. 75:685–705
Nutrients. 2020 Mar; 12(3): 622
30 min - Pathobiochemical linkages between Alzheimer's Disease and Autism Spectrum Disorders: Associative Molecular Patterns with Diverse Pathologies. DJGPhD. 18 May 2021
FASEB J. 2013 Jun; 27(6): 2458–2467.
Scientific Reports volume 7, Article number: 13763 (2017)
30 min - Immunomodulatory effects on neuropsychiatric states: classic rodent model studies. Dr. Guerra. 17.5.21 Authentic Biochemistry
Scientific Reports volume 9, Article number: 1220 (2019)
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12
Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221
Pharmacological reports 2005, vol. 57, no6, pp. 811-817
Brain Res Bull, December 11, 2006; 71(1-3): 279-86.
Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997)
Scientific Reports volume 7, Article number: 13763 (2017)
29 min - Linking TLR's with the VTA and NE circuitry: Immune mediated neurodegeneration and neuroprotection in the balance. DJGPhD 16 May 2021
Brain Behav Immun. 2019 Oct;81:41-51
Neuroimmunomodulation 2002/2003;10:101-121
Front. Neurol., 23 January 2018
30 min - Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling.
TLR interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's.
J Neuroinflammation. 2014 Sep 20;11:166
Brain Behav Immun. 2019 Oct;81:41-51
J Mol Neurosci. 2021 Mar 9
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.